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Tacrolimus ointment is more effective than pimecrolimus cream in adult patients with moderate to very severe atopic dermatitis.
J Dermatolog Treat. 2007; 18(3):151-7.JD

Abstract

OBJECTIVE

To compare the efficacy and safety of tacrolimus ointment 0.1% and pimecrolimus cream 1% in adult patients with moderate to very severe atopic dermatitis (AD).

METHODS

A total of 281 patients (141 treated with tacrolimus and 140 treated with pimecrolimus) were randomized to a multicenter, investigator-blinded, 6-week study.

RESULTS

Tacrolimus-treated patients had significantly greater improvements in the Eczema Area Severity Index score compared with pimecrolimus-treated patients (mean percent reduction from baseline to study end: 57% vs 39%, respectively; p=0.0002). Treatment success was also significantly greater among the tacrolimus-treated patients compared with pimecrolimus-treated patients (40% vs 22% at study end; p=0.001), as was the improvement in percentage of total body surface area affected (a reduction of 49% vs 34% at study end; p=0.01). Both treatment groups had similar improvements in patient assessment of itch. There were no significant differences in the incidences of adverse events, including application-site burning and application-site pruritus, the two most commonly reported adverse events. Significantly more pimecrolimus-treated patients than tacrolimus-treated patients withdrew from the study due to lack of efficacy (10 vs 1, p=0.005).

CONCLUSION

Tacrolimus ointment is more effective than pimecrolimus cream in adults with moderate to very severe AD. Both agents have a similar safety profile.

Authors+Show Affiliations

Wake Forest University, Winston-Salem, NC, USA. afleisch@wfubmc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17538803

Citation

Fleischer, Alan B., et al. "Tacrolimus Ointment Is More Effective Than Pimecrolimus Cream in Adult Patients With Moderate to Very Severe Atopic Dermatitis." The Journal of Dermatological Treatment, vol. 18, no. 3, 2007, pp. 151-7.
Fleischer AB, Abramovits W, Breneman D, et al. Tacrolimus ointment is more effective than pimecrolimus cream in adult patients with moderate to very severe atopic dermatitis. J Dermatolog Treat. 2007;18(3):151-7.
Fleischer, A. B., Abramovits, W., Breneman, D., & Jaracz, E. (2007). Tacrolimus ointment is more effective than pimecrolimus cream in adult patients with moderate to very severe atopic dermatitis. The Journal of Dermatological Treatment, 18(3), 151-7.
Fleischer AB, et al. Tacrolimus Ointment Is More Effective Than Pimecrolimus Cream in Adult Patients With Moderate to Very Severe Atopic Dermatitis. J Dermatolog Treat. 2007;18(3):151-7. PubMed PMID: 17538803.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tacrolimus ointment is more effective than pimecrolimus cream in adult patients with moderate to very severe atopic dermatitis. AU - Fleischer,Alan B,Jr AU - Abramovits,William, AU - Breneman,Debra, AU - Jaracz,Eileen, AU - ,, PY - 2007/6/1/pubmed PY - 2007/7/25/medline PY - 2007/6/1/entrez SP - 151 EP - 7 JF - The Journal of dermatological treatment JO - J Dermatolog Treat VL - 18 IS - 3 N2 - OBJECTIVE: To compare the efficacy and safety of tacrolimus ointment 0.1% and pimecrolimus cream 1% in adult patients with moderate to very severe atopic dermatitis (AD). METHODS: A total of 281 patients (141 treated with tacrolimus and 140 treated with pimecrolimus) were randomized to a multicenter, investigator-blinded, 6-week study. RESULTS: Tacrolimus-treated patients had significantly greater improvements in the Eczema Area Severity Index score compared with pimecrolimus-treated patients (mean percent reduction from baseline to study end: 57% vs 39%, respectively; p=0.0002). Treatment success was also significantly greater among the tacrolimus-treated patients compared with pimecrolimus-treated patients (40% vs 22% at study end; p=0.001), as was the improvement in percentage of total body surface area affected (a reduction of 49% vs 34% at study end; p=0.01). Both treatment groups had similar improvements in patient assessment of itch. There were no significant differences in the incidences of adverse events, including application-site burning and application-site pruritus, the two most commonly reported adverse events. Significantly more pimecrolimus-treated patients than tacrolimus-treated patients withdrew from the study due to lack of efficacy (10 vs 1, p=0.005). CONCLUSION: Tacrolimus ointment is more effective than pimecrolimus cream in adults with moderate to very severe AD. Both agents have a similar safety profile. SN - 0954-6634 UR - https://www.unboundmedicine.com/medline/citation/17538803/Tacrolimus_ointment_is_more_effective_than_pimecrolimus_cream_in_adult_patients_with_moderate_to_very_severe_atopic_dermatitis_ L2 - http://www.tandfonline.com/doi/full/10.1080/09546630701287332 DB - PRIME DP - Unbound Medicine ER -