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Eosinophilic meningitis associated with angiostrongyliasis: clinical features, laboratory investigations and specific diagnostic IgG and IgG subclass antibodies in cerebrospinal fluid.

Abstract

Eosinophilic meningitis (EOM) associated angiostrongyliasis mostly induced by the nematode Angiostrongylus cantonensis, is a common disease with worldwide prevalence. Heavy infections can lead to chronic disabling disease and even death. This study was conducted to shed light on the overall specific IgG antibody response as well as the specific IgG antibody subclass responses in cerebrospinal fluid (CSF) of patients with EOM. Fifteen patients with EOM associated with angiostrongyliasis were included in the study. Sera were screened by immunoblotting for the presence of IgG antibody to the 29 kDaA. cantonensis antigenic polypeptide. CSF was examined by ELISA for the presence of specific IgG and IgG subclass antibodies. Patients presented with headache (100%), neck stiffness (20%), fever (40%), nausea (87%), vomiting (73%), paresthesia (7%), and muscle weakness (7%). Seven of 15 (47%) patients showed peripheral blood eosinophilia and all patients presented with eosinophils in CSF. A sensitivity of 80 % was obtained by combining the diagnostic values of immunoblotting in sera and IgG and IgG subclasses-based ELISA in CSF. The combination of a history of eating raw or semi-cooked infected foods, clinical features, complete blood count, differential cell counts, CSF profiles, and serum and CSF antibodies to A. cantonensis can be used to increase the sensitivity for the diagnosis of human angiostrongyliasis.

Authors+Show Affiliations

Loei Hospital, Ministry of Public Health, Loei, Thailand.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17539242

Citation

Kittimongkolma, Suvicha, et al. "Eosinophilic Meningitis Associated With Angiostrongyliasis: Clinical Features, Laboratory Investigations and Specific Diagnostic IgG and IgG Subclass Antibodies in Cerebrospinal Fluid." The Southeast Asian Journal of Tropical Medicine and Public Health, vol. 38, no. 1, 2007, pp. 24-31.
Kittimongkolma S, Intapan PM, Laemviteevanich K, et al. Eosinophilic meningitis associated with angiostrongyliasis: clinical features, laboratory investigations and specific diagnostic IgG and IgG subclass antibodies in cerebrospinal fluid. Southeast Asian J Trop Med Public Health. 2007;38(1):24-31.
Kittimongkolma, S., Intapan, P. M., Laemviteevanich, K., Kanpittaya, J., Sawanyawisuth, K., & Maleewong, W. (2007). Eosinophilic meningitis associated with angiostrongyliasis: clinical features, laboratory investigations and specific diagnostic IgG and IgG subclass antibodies in cerebrospinal fluid. The Southeast Asian Journal of Tropical Medicine and Public Health, 38(1), 24-31.
Kittimongkolma S, et al. Eosinophilic Meningitis Associated With Angiostrongyliasis: Clinical Features, Laboratory Investigations and Specific Diagnostic IgG and IgG Subclass Antibodies in Cerebrospinal Fluid. Southeast Asian J Trop Med Public Health. 2007;38(1):24-31. PubMed PMID: 17539242.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Eosinophilic meningitis associated with angiostrongyliasis: clinical features, laboratory investigations and specific diagnostic IgG and IgG subclass antibodies in cerebrospinal fluid. AU - Kittimongkolma,Suvicha, AU - Intapan,Pewpan M, AU - Laemviteevanich,Kosol, AU - Kanpittaya,Jaturat, AU - Sawanyawisuth,Kittisak, AU - Maleewong,Wanchai, PY - 2007/6/2/pubmed PY - 2007/8/19/medline PY - 2007/6/2/entrez SP - 24 EP - 31 JF - The Southeast Asian journal of tropical medicine and public health JO - Southeast Asian J Trop Med Public Health VL - 38 IS - 1 N2 - Eosinophilic meningitis (EOM) associated angiostrongyliasis mostly induced by the nematode Angiostrongylus cantonensis, is a common disease with worldwide prevalence. Heavy infections can lead to chronic disabling disease and even death. This study was conducted to shed light on the overall specific IgG antibody response as well as the specific IgG antibody subclass responses in cerebrospinal fluid (CSF) of patients with EOM. Fifteen patients with EOM associated with angiostrongyliasis were included in the study. Sera were screened by immunoblotting for the presence of IgG antibody to the 29 kDaA. cantonensis antigenic polypeptide. CSF was examined by ELISA for the presence of specific IgG and IgG subclass antibodies. Patients presented with headache (100%), neck stiffness (20%), fever (40%), nausea (87%), vomiting (73%), paresthesia (7%), and muscle weakness (7%). Seven of 15 (47%) patients showed peripheral blood eosinophilia and all patients presented with eosinophils in CSF. A sensitivity of 80 % was obtained by combining the diagnostic values of immunoblotting in sera and IgG and IgG subclasses-based ELISA in CSF. The combination of a history of eating raw or semi-cooked infected foods, clinical features, complete blood count, differential cell counts, CSF profiles, and serum and CSF antibodies to A. cantonensis can be used to increase the sensitivity for the diagnosis of human angiostrongyliasis. SN - 0125-1562 UR - https://www.unboundmedicine.com/medline/citation/17539242/Eosinophilic_meningitis_associated_with_angiostrongyliasis:_clinical_features_laboratory_investigations_and_specific_diagnostic_IgG_and_IgG_subclass_antibodies_in_cerebrospinal_fluid_ L2 - https://www.diseaseinfosearch.org/result/468 DB - PRIME DP - Unbound Medicine ER -