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Helicobacter pylori cagA, vacA and iceA genotypes in northern Thai patients with gastric disease.
Southeast Asian J Trop Med Public Health. 2007 Mar; 38(2):356-62.SA

Abstract

Helicobacterpylori, a common infectious bacterium, has been linked to chronic gastritis, peptic ulcer and gastric cancer. Gastric biopsy specimens were obtained from 58 northern Thai patients with gastritis, 28 with gastric ulcer, 45 with duodenal ulcer and 4 with gastric cancer. cagA, vacA s1 and iceA gene was found in 88, 98, and 89% of the specimens, respectively. For vacA, the frequency of subtype s1a, s1c and combined sla and s1c was 40, 16, and 41%, respectively. The frequency of subtype s1a/m1 and s1a/s1c/m1 was 27 and 20%, respectively. Fifty-three patients (39%) were infected with multiple vacA genotypes but there was no association with clinical outcome. cagA positive and mixed vacA s1a and s1c strains were found in significantly more cases of duodenal ulcer than gastritis (p < 0.05). For iceA, subtype iceA1 reached a frequency of 60%, whereas subtype iceA2 was only 24%.

Authors+Show Affiliations

Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50202, Thailand. rhxxo028@chiangmai.ac.thNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17539287

Citation

Linpisarn, Sukanya, et al. "Helicobacter Pylori cagA, vacA and iceA Genotypes in Northern Thai Patients With Gastric Disease." The Southeast Asian Journal of Tropical Medicine and Public Health, vol. 38, no. 2, 2007, pp. 356-62.
Linpisarn S, Suwan W, Lertprasertsuk N, et al. Helicobacter pylori cagA, vacA and iceA genotypes in northern Thai patients with gastric disease. Southeast Asian J Trop Med Public Health. 2007;38(2):356-62.
Linpisarn, S., Suwan, W., Lertprasertsuk, N., Koosirirat, C., Steger, H. F., Prommuangyong, K., & Phornphutkul, K. (2007). Helicobacter pylori cagA, vacA and iceA genotypes in northern Thai patients with gastric disease. The Southeast Asian Journal of Tropical Medicine and Public Health, 38(2), 356-62.
Linpisarn S, et al. Helicobacter Pylori cagA, vacA and iceA Genotypes in Northern Thai Patients With Gastric Disease. Southeast Asian J Trop Med Public Health. 2007;38(2):356-62. PubMed PMID: 17539287.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Helicobacter pylori cagA, vacA and iceA genotypes in northern Thai patients with gastric disease. AU - Linpisarn,Sukanya, AU - Suwan,Warissara, AU - Lertprasertsuk,Nirush, AU - Koosirirat,Chuchart, AU - Steger,Heinrich F, AU - Prommuangyong,Kunrunya, AU - Phornphutkul,Kannikar, PY - 2007/6/2/pubmed PY - 2007/10/11/medline PY - 2007/6/2/entrez SP - 356 EP - 62 JF - The Southeast Asian journal of tropical medicine and public health JO - Southeast Asian J Trop Med Public Health VL - 38 IS - 2 N2 - Helicobacterpylori, a common infectious bacterium, has been linked to chronic gastritis, peptic ulcer and gastric cancer. Gastric biopsy specimens were obtained from 58 northern Thai patients with gastritis, 28 with gastric ulcer, 45 with duodenal ulcer and 4 with gastric cancer. cagA, vacA s1 and iceA gene was found in 88, 98, and 89% of the specimens, respectively. For vacA, the frequency of subtype s1a, s1c and combined sla and s1c was 40, 16, and 41%, respectively. The frequency of subtype s1a/m1 and s1a/s1c/m1 was 27 and 20%, respectively. Fifty-three patients (39%) were infected with multiple vacA genotypes but there was no association with clinical outcome. cagA positive and mixed vacA s1a and s1c strains were found in significantly more cases of duodenal ulcer than gastritis (p < 0.05). For iceA, subtype iceA1 reached a frequency of 60%, whereas subtype iceA2 was only 24%. SN - 0125-1562 UR - https://www.unboundmedicine.com/medline/citation/17539287/Helicobacter_pylori_cagA_vacA_and_iceA_genotypes_in_northern_Thai_patients_with_gastric_disease_ L2 - https://medlineplus.gov/helicobacterpyloriinfections.html DB - PRIME DP - Unbound Medicine ER -