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The association of RANTES polymorphism with severe acute respiratory syndrome in Hong Kong and Beijing Chinese.
BMC Infect Dis. 2007 Jun 01; 7:50.BI

Abstract

BACKGROUND

Chemokines play important roles in inflammation and antiviral action. We examined whether polymorphisms of RANTES, IP-10 and Mig affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS).

METHODS

We tested the polymorphisms of RANTES, IP-10 and Mig for their associations with SARS in 495 Hong Kong Chinese SARS patients and 578 controls. Then we tried to confirm the results in 356 Beijing Chinese SARS patients and 367 controls.

RESULTS

RANTES -28 G allele was associated with SARS susceptibility in Hong Kong Chinese (P < 0.0001, OR = 2.80, 95%CI:2.11-3.71). Individuals with RANTES -28 CG and GG genotypes had a 3.28-fold (95%CI:2.32-4.64) and 3.06-fold (95%CI:1.47-6.39) increased risk of developing SARS respectively (P < 0.0001). This -28 G allele conferred risk of death in a gene-dosage dependent manner (P = 0.014) with CG and GG individuals having a 2.12-fold (95% CI: 1.11-4.06) and 4.01-fold (95% CI: 1.30-12.4) increased risk. For the replication of RANTES data in Beijing Chinese, the -28 G allele was not associated with susceptibility to SARS. However, -28 CG (OR = 4.27, 95%CI:1.64-11.1) and GG (OR = 3.34, 95%CI:0.37-30.7) were associated with admission to intensive care units or death due to SARS (P = 0.011).

CONCLUSION

RANTES -28 G allele plays a role in the pathogenesis of SARS.

Authors+Show Affiliations

Department of Paediatrics and Adolescent Medicine, The Hong Kong Jockey Club Research Centre, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China. ivy_natsu@yahoo.com.hk <ivy_natsu@yahoo.com.hk>No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17540042

Citation

Ng, Man Wai, et al. "The Association of RANTES Polymorphism With Severe Acute Respiratory Syndrome in Hong Kong and Beijing Chinese." BMC Infectious Diseases, vol. 7, 2007, p. 50.
Ng MW, Zhou G, Chong WP, et al. The association of RANTES polymorphism with severe acute respiratory syndrome in Hong Kong and Beijing Chinese. BMC Infect Dis. 2007;7:50.
Ng, M. W., Zhou, G., Chong, W. P., Lee, L. W., Law, H. K., Zhang, H., Wong, W. H., Fok, S. F., Zhai, Y., Yung, R. W., Chow, E. Y., Au, K. L., Chan, E. Y., Lim, W., Peiris, J. S., He, F., & Lau, Y. L. (2007). The association of RANTES polymorphism with severe acute respiratory syndrome in Hong Kong and Beijing Chinese. BMC Infectious Diseases, 7, 50.
Ng MW, et al. The Association of RANTES Polymorphism With Severe Acute Respiratory Syndrome in Hong Kong and Beijing Chinese. BMC Infect Dis. 2007 Jun 1;7:50. PubMed PMID: 17540042.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The association of RANTES polymorphism with severe acute respiratory syndrome in Hong Kong and Beijing Chinese. AU - Ng,Man Wai, AU - Zhou,Gangqiao, AU - Chong,Wai Po, AU - Lee,Loretta Wing Yan, AU - Law,Helen Ka Wai, AU - Zhang,Hongxing, AU - Wong,Wilfred Hing Sang, AU - Fok,Susanna Fung Shan, AU - Zhai,Yun, AU - Yung,Raymond W H, AU - Chow,Eudora Y, AU - Au,Ka Leung, AU - Chan,Eric Y T, AU - Lim,Wilina, AU - Peiris,J S Malik, AU - He,Fuchu, AU - Lau,Yu Lung, Y1 - 2007/06/01/ PY - 2007/02/08/received PY - 2007/06/01/accepted PY - 2007/6/2/pubmed PY - 2007/7/24/medline PY - 2007/6/2/entrez SP - 50 EP - 50 JF - BMC infectious diseases JO - BMC Infect Dis VL - 7 N2 - BACKGROUND: Chemokines play important roles in inflammation and antiviral action. We examined whether polymorphisms of RANTES, IP-10 and Mig affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS). METHODS: We tested the polymorphisms of RANTES, IP-10 and Mig for their associations with SARS in 495 Hong Kong Chinese SARS patients and 578 controls. Then we tried to confirm the results in 356 Beijing Chinese SARS patients and 367 controls. RESULTS: RANTES -28 G allele was associated with SARS susceptibility in Hong Kong Chinese (P < 0.0001, OR = 2.80, 95%CI:2.11-3.71). Individuals with RANTES -28 CG and GG genotypes had a 3.28-fold (95%CI:2.32-4.64) and 3.06-fold (95%CI:1.47-6.39) increased risk of developing SARS respectively (P < 0.0001). This -28 G allele conferred risk of death in a gene-dosage dependent manner (P = 0.014) with CG and GG individuals having a 2.12-fold (95% CI: 1.11-4.06) and 4.01-fold (95% CI: 1.30-12.4) increased risk. For the replication of RANTES data in Beijing Chinese, the -28 G allele was not associated with susceptibility to SARS. However, -28 CG (OR = 4.27, 95%CI:1.64-11.1) and GG (OR = 3.34, 95%CI:0.37-30.7) were associated with admission to intensive care units or death due to SARS (P = 0.011). CONCLUSION: RANTES -28 G allele plays a role in the pathogenesis of SARS. SN - 1471-2334 UR - https://www.unboundmedicine.com/medline/citation/17540042/The_association_of_RANTES_polymorphism_with_severe_acute_respiratory_syndrome_in_Hong_Kong_and_Beijing_Chinese_ L2 - https://bmcinfectdis.biomedcentral.com/articles/10.1186/1471-2334-7-50 DB - PRIME DP - Unbound Medicine ER -