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Guideline-adherent antithrombotic treatment is associated with improved outcomes compared with undertreatment in high-risk patients with atrial fibrillation. The Euro Heart Survey on Atrial Fibrillation.
Am Heart J. 2007 Jun; 153(6):1006-12.AH

Abstract

BACKGROUND

The Euro Heart Survey showed that antithrombotic treatment in patients with atrial fibrillation (AF) was moderately tailored to the 2001 American College of Cardiology, American Heart Association, and European Society of Cardiology (ACC/AHA/ESC) guidelines for the management of AF. What consequences does guideline-deviant antithrombotic treatment have in daily practice?

METHODS

In the Euro Heart Survey on AF (2003-2004), an observational study on AF care in European cardiology practices, information was available on baseline stroke risk profile and antithrombotic drug treatment and on cardiovascular events during 1-year follow-up. Antithrombotic guideline adherence is assessed according to the 2001 ACC/AHA/ESC guidelines. Multivariable logistic regression was performed to assess the association of guideline deviance with adverse outcome.

RESULTS

The effect of antithrombotic guideline deviance was analyzed exclusively in 3634 high-risk patients with AF because these composed the majority (89%) and because few cardiovascular events occurred in low-risk patients. Among high-risk patients, antithrombotic treatment was in agreement with the guidelines in 61% of patients, whereas 28% were undertreated and 11% overtreated. Compared to guideline adherence, undertreatment was associated with a higher chance of thromboembolism (odds ratio [OR], 1.97; 95% CI, 1.29-3.01; P = .004) and the combined end point of cardiovascular death, thromboembolism, or major bleeding (OR, 1.54; 95% CI, 1.14-2.10; P = .024). This increased risk was nonsignificant for the end point of stroke alone (OR, 1.42; 95% CI, 0.82-2.46; P = .170). Overtreatment was nonsignificantly associated with a higher risk for major bleeding (OR, 1.52; 95% CI, 0.76-3.02; P = .405).

CONCLUSIONS

Antithrombotic undertreatment of high-risk patients with AF was associated with a worse cardiovascular prognosis during 1 year, whereas overtreatment was not associated with a higher chance for major bleeding.

Authors+Show Affiliations

Department of Cardiology, University Hospital Maastricht, Maastricht, The Netherlands. r.nieuwlaat@cardio.azm.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17540203

Citation

Nieuwlaat, Robby, et al. "Guideline-adherent Antithrombotic Treatment Is Associated With Improved Outcomes Compared With Undertreatment in High-risk Patients With Atrial Fibrillation. the Euro Heart Survey On Atrial Fibrillation." American Heart Journal, vol. 153, no. 6, 2007, pp. 1006-12.
Nieuwlaat R, Olsson SB, Lip GY, et al. Guideline-adherent antithrombotic treatment is associated with improved outcomes compared with undertreatment in high-risk patients with atrial fibrillation. The Euro Heart Survey on Atrial Fibrillation. Am Heart J. 2007;153(6):1006-12.
Nieuwlaat, R., Olsson, S. B., Lip, G. Y., Camm, A. J., Breithardt, G., Capucci, A., Meeder, J. G., Prins, M. H., Lévy, S., & Crijns, H. J. (2007). Guideline-adherent antithrombotic treatment is associated with improved outcomes compared with undertreatment in high-risk patients with atrial fibrillation. The Euro Heart Survey on Atrial Fibrillation. American Heart Journal, 153(6), 1006-12.
Nieuwlaat R, et al. Guideline-adherent Antithrombotic Treatment Is Associated With Improved Outcomes Compared With Undertreatment in High-risk Patients With Atrial Fibrillation. the Euro Heart Survey On Atrial Fibrillation. Am Heart J. 2007;153(6):1006-12. PubMed PMID: 17540203.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Guideline-adherent antithrombotic treatment is associated with improved outcomes compared with undertreatment in high-risk patients with atrial fibrillation. The Euro Heart Survey on Atrial Fibrillation. AU - Nieuwlaat,Robby, AU - Olsson,S Bertil, AU - Lip,Gregory Y H, AU - Camm,A John, AU - Breithardt,Günter, AU - Capucci,Alessandro, AU - Meeder,Joan G, AU - Prins,Martin H, AU - Lévy,Samuel, AU - Crijns,Harry J G M, AU - ,, PY - 2006/11/08/received PY - 2007/03/02/accepted PY - 2007/6/2/pubmed PY - 2007/6/15/medline PY - 2007/6/2/entrez SP - 1006 EP - 12 JF - American heart journal JO - Am Heart J VL - 153 IS - 6 N2 - BACKGROUND: The Euro Heart Survey showed that antithrombotic treatment in patients with atrial fibrillation (AF) was moderately tailored to the 2001 American College of Cardiology, American Heart Association, and European Society of Cardiology (ACC/AHA/ESC) guidelines for the management of AF. What consequences does guideline-deviant antithrombotic treatment have in daily practice? METHODS: In the Euro Heart Survey on AF (2003-2004), an observational study on AF care in European cardiology practices, information was available on baseline stroke risk profile and antithrombotic drug treatment and on cardiovascular events during 1-year follow-up. Antithrombotic guideline adherence is assessed according to the 2001 ACC/AHA/ESC guidelines. Multivariable logistic regression was performed to assess the association of guideline deviance with adverse outcome. RESULTS: The effect of antithrombotic guideline deviance was analyzed exclusively in 3634 high-risk patients with AF because these composed the majority (89%) and because few cardiovascular events occurred in low-risk patients. Among high-risk patients, antithrombotic treatment was in agreement with the guidelines in 61% of patients, whereas 28% were undertreated and 11% overtreated. Compared to guideline adherence, undertreatment was associated with a higher chance of thromboembolism (odds ratio [OR], 1.97; 95% CI, 1.29-3.01; P = .004) and the combined end point of cardiovascular death, thromboembolism, or major bleeding (OR, 1.54; 95% CI, 1.14-2.10; P = .024). This increased risk was nonsignificant for the end point of stroke alone (OR, 1.42; 95% CI, 0.82-2.46; P = .170). Overtreatment was nonsignificantly associated with a higher risk for major bleeding (OR, 1.52; 95% CI, 0.76-3.02; P = .405). CONCLUSIONS: Antithrombotic undertreatment of high-risk patients with AF was associated with a worse cardiovascular prognosis during 1 year, whereas overtreatment was not associated with a higher chance for major bleeding. SN - 1097-6744 UR - https://www.unboundmedicine.com/medline/citation/17540203/Guideline_adherent_antithrombotic_treatment_is_associated_with_improved_outcomes_compared_with_undertreatment_in_high_risk_patients_with_atrial_fibrillation__The_Euro_Heart_Survey_on_Atrial_Fibrillation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-8703(07)00214-1 DB - PRIME DP - Unbound Medicine ER -