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Flavonoids with anti-inflammatory and antinociceptive activity from Cistus laurifolius L. leaves through bioassay-guided procedures.
J Ethnopharmacol. 2007 Jul 25; 112(3):524-30.JE

Abstract

Extracts obtained from the leaves and branches of various Cistus species have been used worldwide as folk remedy for the treatment of various inflammatory ailments including rheumatism and renal inflammations. Effects of the extracts and fractions from the leaves with non-woody branches of Cistus laurifolius L. (Cistaceae) were studied using two in vivo models of inflammation in mice. Model one was based on observed potent inhibitory activity against carrageenan-induced hind paw oedema and the second model used was acetic acid-induced, increased vascular permeability model. Through bioassay-guided fractionation and isolation procedures three flavonoids; 3-O-methylquercetin (1), 3,7-O-dimethylquercetin (2) and 3,7-O-dimethylkaempferol (3) were isolated as the main active ingredients from the ethanol extract. Later on, these flavonoids were shown to possess potent antinociceptive activity, which was assessed through inhibition of p-benzoquinone-induced writhing reflex. Results of the present study have clearly supported the utilization of Cistus laurifolius in Turkish traditional medicine. Subsequently, three flavonoids were shown to have strong antinociceptive and anti-inflammatory activities, per os without inducing any apparent acute toxicity as well as gastric damage.

Authors+Show Affiliations

Gazi University, Faculty of Pharmacy, Department of Pharmacognosy, Etiler 06330, Ankara, Turkey.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17540523

Citation

Küpeli, Esra, and Erdem Yesilada. "Flavonoids With Anti-inflammatory and Antinociceptive Activity From Cistus Laurifolius L. Leaves Through Bioassay-guided Procedures." Journal of Ethnopharmacology, vol. 112, no. 3, 2007, pp. 524-30.
Küpeli E, Yesilada E. Flavonoids with anti-inflammatory and antinociceptive activity from Cistus laurifolius L. leaves through bioassay-guided procedures. J Ethnopharmacol. 2007;112(3):524-30.
Küpeli, E., & Yesilada, E. (2007). Flavonoids with anti-inflammatory and antinociceptive activity from Cistus laurifolius L. leaves through bioassay-guided procedures. Journal of Ethnopharmacology, 112(3), 524-30.
Küpeli E, Yesilada E. Flavonoids With Anti-inflammatory and Antinociceptive Activity From Cistus Laurifolius L. Leaves Through Bioassay-guided Procedures. J Ethnopharmacol. 2007 Jul 25;112(3):524-30. PubMed PMID: 17540523.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Flavonoids with anti-inflammatory and antinociceptive activity from Cistus laurifolius L. leaves through bioassay-guided procedures. AU - Küpeli,Esra, AU - Yesilada,Erdem, Y1 - 2007/04/25/ PY - 2007/02/02/received PY - 2007/04/11/revised PY - 2007/04/18/accepted PY - 2007/6/2/pubmed PY - 2007/12/13/medline PY - 2007/6/2/entrez SP - 524 EP - 30 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 112 IS - 3 N2 - Extracts obtained from the leaves and branches of various Cistus species have been used worldwide as folk remedy for the treatment of various inflammatory ailments including rheumatism and renal inflammations. Effects of the extracts and fractions from the leaves with non-woody branches of Cistus laurifolius L. (Cistaceae) were studied using two in vivo models of inflammation in mice. Model one was based on observed potent inhibitory activity against carrageenan-induced hind paw oedema and the second model used was acetic acid-induced, increased vascular permeability model. Through bioassay-guided fractionation and isolation procedures three flavonoids; 3-O-methylquercetin (1), 3,7-O-dimethylquercetin (2) and 3,7-O-dimethylkaempferol (3) were isolated as the main active ingredients from the ethanol extract. Later on, these flavonoids were shown to possess potent antinociceptive activity, which was assessed through inhibition of p-benzoquinone-induced writhing reflex. Results of the present study have clearly supported the utilization of Cistus laurifolius in Turkish traditional medicine. Subsequently, three flavonoids were shown to have strong antinociceptive and anti-inflammatory activities, per os without inducing any apparent acute toxicity as well as gastric damage. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/17540523/Flavonoids_with_anti_inflammatory_and_antinociceptive_activity_from_Cistus_laurifolius_L__leaves_through_bioassay_guided_procedures_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(07)00212-7 DB - PRIME DP - Unbound Medicine ER -