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Lrrk2-associated parkinsonism is a major cause of disease in Northern Spain.
Parkinsonism Relat Disord. 2007 Dec; 13(8):509-15.PR

Abstract

Herein we describe a comparative clinical and genetic study of Lrrk2-associated parkinsonism in Northern Spain. In our sample from the Basque region, Lrrk2 R1441G and G2019S account for 15 out of 50 kindreds (30%) with familial Parkinson's disease. We observe common founder haplotypes for both R1441G and G2019S carriers. Our findings highlight the importance of Lrrk2 parkinsonism in this population and may have important consequences for its extended Diaspora in North, Central and South Americas.

Authors+Show Affiliations

Servicio General de Investigación Genómica, Banco de ADN and Departamento de Z.y Biología Celular A., Universidad del País Vasco, Vitoria-Gasteiz, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17540608

Citation

González-Fernández, María C., et al. "Lrrk2-associated Parkinsonism Is a Major Cause of Disease in Northern Spain." Parkinsonism & Related Disorders, vol. 13, no. 8, 2007, pp. 509-15.
González-Fernández MC, Lezcano E, Ross OA, et al. Lrrk2-associated parkinsonism is a major cause of disease in Northern Spain. Parkinsonism Relat Disord. 2007;13(8):509-15.
González-Fernández, M. C., Lezcano, E., Ross, O. A., Gómez-Esteban, J. C., Gómez-Busto, F., Velasco, F., Alvarez-Alvarez, M., Rodríguez-Martínez, M. B., Ciordia, R., Zarranz, J. J., Farrer, M. J., Mata, I. F., & de Pancorbo, M. M. (2007). Lrrk2-associated parkinsonism is a major cause of disease in Northern Spain. Parkinsonism & Related Disorders, 13(8), 509-15.
González-Fernández MC, et al. Lrrk2-associated Parkinsonism Is a Major Cause of Disease in Northern Spain. Parkinsonism Relat Disord. 2007;13(8):509-15. PubMed PMID: 17540608.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lrrk2-associated parkinsonism is a major cause of disease in Northern Spain. AU - González-Fernández,María C, AU - Lezcano,Elena, AU - Ross,Owen A, AU - Gómez-Esteban,Juan C, AU - Gómez-Busto,Fernando, AU - Velasco,Fernando, AU - Alvarez-Alvarez,Maite, AU - Rodríguez-Martínez,María B, AU - Ciordia,Roberto, AU - Zarranz,Juan J, AU - Farrer,Matthew J, AU - Mata,Ignacio F, AU - de Pancorbo,Marian M, Y1 - 2007/05/30/ PY - 2006/12/22/received PY - 2007/04/04/revised PY - 2007/04/05/accepted PY - 2007/6/2/pubmed PY - 2008/3/15/medline PY - 2007/6/2/entrez SP - 509 EP - 15 JF - Parkinsonism & related disorders JO - Parkinsonism Relat Disord VL - 13 IS - 8 N2 - Herein we describe a comparative clinical and genetic study of Lrrk2-associated parkinsonism in Northern Spain. In our sample from the Basque region, Lrrk2 R1441G and G2019S account for 15 out of 50 kindreds (30%) with familial Parkinson's disease. We observe common founder haplotypes for both R1441G and G2019S carriers. Our findings highlight the importance of Lrrk2 parkinsonism in this population and may have important consequences for its extended Diaspora in North, Central and South Americas. SN - 1353-8020 UR - https://www.unboundmedicine.com/medline/citation/17540608/Lrrk2_associated_parkinsonism_is_a_major_cause_of_disease_in_Northern_Spain_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1353-8020(07)00069-7 DB - PRIME DP - Unbound Medicine ER -