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Primary cutaneous zygomycosis in two immunocompromised children.
Pediatr Dermatol. 2007 May-Jun; 24(3):257-62.PD

Abstract

Zygomycosis, often referred to as ''mucormycosis'' or ''phycomycosis,'' is a rapidly progressive fungal infection which usually occurs in immunocompromised individuals, and is characterized by soft tissue destruction and invasion of blood vessels. The rare and easily misdiagnosed primary cutaneous form may present as a superficial erosion with a painless, gradual onset and slow progression of symptoms or a gangrenous, necrotic ulceration due to rapid tissue and vascular invasion. With the latter form, the mortality rate among affected individuals is high even after aggressive surgical debridement and amphotericin B administration, emphasizing the importance of early recognition and proper diagnosis. We present two instances of gangrenous cutaneous zygomycosis in immunocompromised children and review the literature with regard to etiology, diagnosis and treatment, highlighting the pediatric population.

Authors+Show Affiliations

Cantatore-Francis JL
SUNY Downstate Department of Dermatology, Brooklyn, New York 11203, USA. julie.cantatore@gmail.com
Shin HT
No affiliation info available
Heilman E
No affiliation info available
Glick SA
No affiliation info available

MeSH

AIDS-Related Opportunistic InfectionsAdolescentAlternariaAmphotericin BAntifungal AgentsChildDebridementDermatomycosesFemaleHumansImmunocompromised HostLeukemia, Myeloid, AcuteNecrosisSkinZygomycosis

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17542876

Citation

Cantatore-Francis, Julie L., et al. "Primary Cutaneous Zygomycosis in Two Immunocompromised Children." Pediatric Dermatology, vol. 24, no. 3, 2007, pp. 257-62.
Cantatore-Francis JL, Shin HT, Heilman E, et al. Primary cutaneous zygomycosis in two immunocompromised children. Pediatr Dermatol. 2007;24(3):257-62.
Cantatore-Francis, J. L., Shin, H. T., Heilman, E., & Glick, S. A. (2007). Primary cutaneous zygomycosis in two immunocompromised children. Pediatric Dermatology, 24(3), 257-62.
Cantatore-Francis JL, et al. Primary Cutaneous Zygomycosis in Two Immunocompromised Children. Pediatr Dermatol. 2007 May-Jun;24(3):257-62. PubMed PMID: 17542876.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Primary cutaneous zygomycosis in two immunocompromised children. AU - Cantatore-Francis,Julie L, AU - Shin,Helen T, AU - Heilman,Edward, AU - Glick,Sharon A, PY - 2007/6/5/pubmed PY - 2007/8/1/medline PY - 2007/6/5/entrez SP - 257 EP - 62 JF - Pediatric dermatology JO - Pediatr Dermatol VL - 24 IS - 3 N2 - Zygomycosis, often referred to as ''mucormycosis'' or ''phycomycosis,'' is a rapidly progressive fungal infection which usually occurs in immunocompromised individuals, and is characterized by soft tissue destruction and invasion of blood vessels. The rare and easily misdiagnosed primary cutaneous form may present as a superficial erosion with a painless, gradual onset and slow progression of symptoms or a gangrenous, necrotic ulceration due to rapid tissue and vascular invasion. With the latter form, the mortality rate among affected individuals is high even after aggressive surgical debridement and amphotericin B administration, emphasizing the importance of early recognition and proper diagnosis. We present two instances of gangrenous cutaneous zygomycosis in immunocompromised children and review the literature with regard to etiology, diagnosis and treatment, highlighting the pediatric population. SN - 0736-8046 UR - https://www.unboundmedicine.com/medline/citation/17542876/Primary_cutaneous_zygomycosis_in_two_immunocompromised_children_ DB - PRIME DP - Unbound Medicine ER -