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Uterine leiomyosarcomas are characterized by high p16, p53 and MIB1 expression in comparison with usual leiomyomas, leiomyoma variants and smooth muscle tumours of uncertain malignant potential.
Histopathology. 2007 Jun; 50(7):851-8.H

Abstract

AIMS

It has been suggested that p16 is overexpressed in uterine leiomyosarcomas in comparison with leiomyomas. In this study, p16 immunohistochemical expression was assessed in a variety of uterine smooth muscle tumours, including usual leiomyomas, leiomyoma variants, smooth muscle tumours of uncertain malignant potential (STUMPs) and leiomyosarcomas. The aim was to ascertain whether there are differences in p16 expression between these groups and whether p16 is of potential value in the assessment of problematic uterine smooth muscle neoplasms. p16 expression was also compared with that of p53 and MIB1.

METHODS AND RESULTS

Cases of usual leiomyoma (n = 10), leiomyoma variants (n = 27), STUMP (n = 4) and leiomyosarcoma (n = 22) were subject to p16, p53 and MIB1 immunohistochemistry. For p16, cases were evaluated with respect to both staining distribution and intensity. There was a statistically significant difference in p16 distribution (P < 0.001) and intensity (P = 0.001) between leiomyosarcomas and the other groups. There was no difference in p16 expression between usual leiomyomas, leiomyoma variants and STUMPs. There were also statistically significant differences in p53 (P = 0.014) and MIB1 (P < 0.001) immunoreactivity between leiomyosarcomas and the other groups.

CONCLUSIONS

p16 is overexpressed in uterine leiomyosarcomas compared with leiomyomas, benign leiomyoma variants and STUMPs, suggesting that p16 may be implicated in the pathogenesis of malignant uterine smooth muscle neoplasms. p16, in combination with p53 and MIB1, may be of value as an adjunct to morphological examination in the assessment of problematic uterine smooth muscle tumours, although further large-scale studies with follow-up are necessary to confirm this.

Authors+Show Affiliations

Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland, UK.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17543074

Citation

O'Neill, C J., et al. "Uterine Leiomyosarcomas Are Characterized By High P16, P53 and MIB1 Expression in Comparison With Usual Leiomyomas, Leiomyoma Variants and Smooth Muscle Tumours of Uncertain Malignant Potential." Histopathology, vol. 50, no. 7, 2007, pp. 851-8.
O'Neill CJ, McBride HA, Connolly LE, et al. Uterine leiomyosarcomas are characterized by high p16, p53 and MIB1 expression in comparison with usual leiomyomas, leiomyoma variants and smooth muscle tumours of uncertain malignant potential. Histopathology. 2007;50(7):851-8.
O'Neill, C. J., McBride, H. A., Connolly, L. E., & McCluggage, W. G. (2007). Uterine leiomyosarcomas are characterized by high p16, p53 and MIB1 expression in comparison with usual leiomyomas, leiomyoma variants and smooth muscle tumours of uncertain malignant potential. Histopathology, 50(7), 851-8.
O'Neill CJ, et al. Uterine Leiomyosarcomas Are Characterized By High P16, P53 and MIB1 Expression in Comparison With Usual Leiomyomas, Leiomyoma Variants and Smooth Muscle Tumours of Uncertain Malignant Potential. Histopathology. 2007;50(7):851-8. PubMed PMID: 17543074.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Uterine leiomyosarcomas are characterized by high p16, p53 and MIB1 expression in comparison with usual leiomyomas, leiomyoma variants and smooth muscle tumours of uncertain malignant potential. AU - O'Neill,C J, AU - McBride,H A, AU - Connolly,L E, AU - McCluggage,W G, PY - 2007/6/5/pubmed PY - 2007/7/13/medline PY - 2007/6/5/entrez SP - 851 EP - 8 JF - Histopathology JO - Histopathology VL - 50 IS - 7 N2 - AIMS: It has been suggested that p16 is overexpressed in uterine leiomyosarcomas in comparison with leiomyomas. In this study, p16 immunohistochemical expression was assessed in a variety of uterine smooth muscle tumours, including usual leiomyomas, leiomyoma variants, smooth muscle tumours of uncertain malignant potential (STUMPs) and leiomyosarcomas. The aim was to ascertain whether there are differences in p16 expression between these groups and whether p16 is of potential value in the assessment of problematic uterine smooth muscle neoplasms. p16 expression was also compared with that of p53 and MIB1. METHODS AND RESULTS: Cases of usual leiomyoma (n = 10), leiomyoma variants (n = 27), STUMP (n = 4) and leiomyosarcoma (n = 22) were subject to p16, p53 and MIB1 immunohistochemistry. For p16, cases were evaluated with respect to both staining distribution and intensity. There was a statistically significant difference in p16 distribution (P < 0.001) and intensity (P = 0.001) between leiomyosarcomas and the other groups. There was no difference in p16 expression between usual leiomyomas, leiomyoma variants and STUMPs. There were also statistically significant differences in p53 (P = 0.014) and MIB1 (P < 0.001) immunoreactivity between leiomyosarcomas and the other groups. CONCLUSIONS: p16 is overexpressed in uterine leiomyosarcomas compared with leiomyomas, benign leiomyoma variants and STUMPs, suggesting that p16 may be implicated in the pathogenesis of malignant uterine smooth muscle neoplasms. p16, in combination with p53 and MIB1, may be of value as an adjunct to morphological examination in the assessment of problematic uterine smooth muscle tumours, although further large-scale studies with follow-up are necessary to confirm this. SN - 0309-0167 UR - https://www.unboundmedicine.com/medline/citation/17543074/Uterine_leiomyosarcomas_are_characterized_by_high_p16_p53_and_MIB1_expression_in_comparison_with_usual_leiomyomas_leiomyoma_variants_and_smooth_muscle_tumours_of_uncertain_malignant_potential_ L2 - https://doi.org/10.1111/j.1365-2559.2007.02699.x DB - PRIME DP - Unbound Medicine ER -