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Anti-Müllerian hormone substance from follicular fluid is positively associated with success in oocyte fertilization during in vitro fertilization.
Fertil Steril. 2008 Mar; 89(3):586-91.FS

Abstract

OBJECTIVE

To determine whether the anti-Müllerian hormone (AMH) level in follicular fluid is associated with success in oocyte fertilization during in vitro fertilization (IVF) cycles.

DESIGN

Retrospective study.

SETTING

Tokyo Medical University hospital.

PATIENT(S)

Thirty-one women undergoing IVF cycles.

INTERVENTION(S)

The women were divided into two groups according to the success or failure of fertilization. Follicular fluid samples were obtained from a single follicle in each patient.

MAIN OUTCOME MEASURE(S)

Assessment of values for AMH, inhibin B, and estradiol from follicular fluid and serum on the day of oocyte retrieval during IVF treatment.

RESULT(S)

The follicular fluid AMH levels from fertilized patients (group 1) were 3.42 times higher than from nonfertilized (group 2). There was no correlation between the ratio of the high quality grade embryos and either serum AMH or inhibin B levels. There was no statistically significant correlation between serum AMH and the number of oocytes. However, there was a strong correlation between levels of serum estradiol, inhibin B, and the number of oocytes.

CONCLUSION(S)

Oocytes are more likely to be fertilized when follicles are able to make high concentrations of AMH in the follicular fluid. Thus, AMH could be a prediction marker for fertilization.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Tokyo Medical University, Tokyo, Japan. chie@tokyo-med.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17543956

Citation

Takahashi, Chie, et al. "Anti-Müllerian Hormone Substance From Follicular Fluid Is Positively Associated With Success in Oocyte Fertilization During in Vitro Fertilization." Fertility and Sterility, vol. 89, no. 3, 2008, pp. 586-91.
Takahashi C, Fujito A, Kazuka M, et al. Anti-Müllerian hormone substance from follicular fluid is positively associated with success in oocyte fertilization during in vitro fertilization. Fertil Steril. 2008;89(3):586-91.
Takahashi, C., Fujito, A., Kazuka, M., Sugiyama, R., Ito, H., & Isaka, K. (2008). Anti-Müllerian hormone substance from follicular fluid is positively associated with success in oocyte fertilization during in vitro fertilization. Fertility and Sterility, 89(3), 586-91.
Takahashi C, et al. Anti-Müllerian Hormone Substance From Follicular Fluid Is Positively Associated With Success in Oocyte Fertilization During in Vitro Fertilization. Fertil Steril. 2008;89(3):586-91. PubMed PMID: 17543956.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-Müllerian hormone substance from follicular fluid is positively associated with success in oocyte fertilization during in vitro fertilization. AU - Takahashi,Chie, AU - Fujito,Atsuya, AU - Kazuka,Masahiro, AU - Sugiyama,Rie, AU - Ito,Hiroe, AU - Isaka,Keiichi, Y1 - 2007/06/04/ PY - 2006/12/14/received PY - 2007/03/27/revised PY - 2007/03/27/accepted PY - 2007/6/5/pubmed PY - 2008/3/28/medline PY - 2007/6/5/entrez SP - 586 EP - 91 JF - Fertility and sterility JO - Fertil Steril VL - 89 IS - 3 N2 - OBJECTIVE: To determine whether the anti-Müllerian hormone (AMH) level in follicular fluid is associated with success in oocyte fertilization during in vitro fertilization (IVF) cycles. DESIGN: Retrospective study. SETTING: Tokyo Medical University hospital. PATIENT(S): Thirty-one women undergoing IVF cycles. INTERVENTION(S): The women were divided into two groups according to the success or failure of fertilization. Follicular fluid samples were obtained from a single follicle in each patient. MAIN OUTCOME MEASURE(S): Assessment of values for AMH, inhibin B, and estradiol from follicular fluid and serum on the day of oocyte retrieval during IVF treatment. RESULT(S): The follicular fluid AMH levels from fertilized patients (group 1) were 3.42 times higher than from nonfertilized (group 2). There was no correlation between the ratio of the high quality grade embryos and either serum AMH or inhibin B levels. There was no statistically significant correlation between serum AMH and the number of oocytes. However, there was a strong correlation between levels of serum estradiol, inhibin B, and the number of oocytes. CONCLUSION(S): Oocytes are more likely to be fertilized when follicles are able to make high concentrations of AMH in the follicular fluid. Thus, AMH could be a prediction marker for fertilization. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/17543956/Anti_Müllerian_hormone_substance_from_follicular_fluid_is_positively_associated_with_success_in_oocyte_fertilization_during_in_vitro_fertilization_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(07)00819-9 DB - PRIME DP - Unbound Medicine ER -