Tags

Type your tag names separated by a space and hit enter

Presence of virulence and fitness gene modules of enterohemorrhagic Escherichia coli in atypical enteropathogenic Escherichia coli O26.
Microbes Infect. 2007 Jun; 9(7):891-7.MI

Abstract

Enterohemorrhagic Escherichia coli (EHEC) strains of serogroup O26 cause hemolytic-uremic syndrome (HUS) whereas atypical enteropathogenic E. coli (aEPEC) O26 typically cause uncomplicated diarrhea but have been also isolated from HUS patients. To gain insight into the virulence of aEPEC O26, we compared the presence of O island (OI) 122, which is associated with enhanced virulence in EHEC strains, among aEPEC O26 and EHEC O26 clinical isolates. We also tested these strains for the high pathogenicity island (HPI) which is a fitness island. All 20 aEPEC O26 and 20 EHEC O26 investigated contained virulence genes located within OI-122 (efa1/lifA, nleB, nleE, ent). In both aEPEC O26 and EHEC O26, OI-122 was linked to the locus for enterocyte effacement, forming a mosaic island which was integrated in pheU. Moreover, strains of these two pathotypes shared a conserved HPI. These data support a close relatedness between aEPEC O26 and EHEC O26 and have evolutionary implications. The presence of OI-122 in aEPEC O26 might contribute to their pathogenic potential.

Authors+Show Affiliations

Institute for Hygiene, and the National Consulting Laboratory on Hemolytic Uremic Syndrome, University of Münster, Robert Koch Strasse 41, D-48149 Münster, Germany. mbiela@uni-muenster.deNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17544311

Citation

Bielaszewska, Martina, et al. "Presence of Virulence and Fitness Gene Modules of Enterohemorrhagic Escherichia Coli in Atypical Enteropathogenic Escherichia Coli O26." Microbes and Infection, vol. 9, no. 7, 2007, pp. 891-7.
Bielaszewska M, Sonntag AK, Schmidt MA, et al. Presence of virulence and fitness gene modules of enterohemorrhagic Escherichia coli in atypical enteropathogenic Escherichia coli O26. Microbes Infect. 2007;9(7):891-7.
Bielaszewska, M., Sonntag, A. K., Schmidt, M. A., & Karch, H. (2007). Presence of virulence and fitness gene modules of enterohemorrhagic Escherichia coli in atypical enteropathogenic Escherichia coli O26. Microbes and Infection, 9(7), 891-7.
Bielaszewska M, et al. Presence of Virulence and Fitness Gene Modules of Enterohemorrhagic Escherichia Coli in Atypical Enteropathogenic Escherichia Coli O26. Microbes Infect. 2007;9(7):891-7. PubMed PMID: 17544311.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Presence of virulence and fitness gene modules of enterohemorrhagic Escherichia coli in atypical enteropathogenic Escherichia coli O26. AU - Bielaszewska,Martina, AU - Sonntag,Anne-Katharina, AU - Schmidt,M Alexander, AU - Karch,Helge, Y1 - 2007/03/21/ PY - 2007/01/22/received PY - 2007/03/12/revised PY - 2007/03/13/accepted PY - 2007/6/5/pubmed PY - 2007/10/27/medline PY - 2007/6/5/entrez SP - 891 EP - 7 JF - Microbes and infection JO - Microbes Infect VL - 9 IS - 7 N2 - Enterohemorrhagic Escherichia coli (EHEC) strains of serogroup O26 cause hemolytic-uremic syndrome (HUS) whereas atypical enteropathogenic E. coli (aEPEC) O26 typically cause uncomplicated diarrhea but have been also isolated from HUS patients. To gain insight into the virulence of aEPEC O26, we compared the presence of O island (OI) 122, which is associated with enhanced virulence in EHEC strains, among aEPEC O26 and EHEC O26 clinical isolates. We also tested these strains for the high pathogenicity island (HPI) which is a fitness island. All 20 aEPEC O26 and 20 EHEC O26 investigated contained virulence genes located within OI-122 (efa1/lifA, nleB, nleE, ent). In both aEPEC O26 and EHEC O26, OI-122 was linked to the locus for enterocyte effacement, forming a mosaic island which was integrated in pheU. Moreover, strains of these two pathotypes shared a conserved HPI. These data support a close relatedness between aEPEC O26 and EHEC O26 and have evolutionary implications. The presence of OI-122 in aEPEC O26 might contribute to their pathogenic potential. SN - 1286-4579 UR - https://www.unboundmedicine.com/medline/citation/17544311/Presence_of_virulence_and_fitness_gene_modules_of_enterohemorrhagic_Escherichia_coli_in_atypical_enteropathogenic_Escherichia_coli_O26_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1286-4579(07)00125-6 DB - PRIME DP - Unbound Medicine ER -