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Depression, antidepressants, and plasma amyloid beta (Beta) peptides in those elderly who do not have cardiovascular disease.
Biol Psychiatry. 2007 Dec 15; 62(12):1413-7.BP

Abstract

BACKGROUND

Low plasma amyloid-beta peptide 42 (Abeta42) is associated with depressive symptoms independently of cardiovascular disease (CVD) in the elderly. It is critical to investigate whether antidepressants modify this relationship.

METHODS

We evaluated 324 elders without CVD in a cross-sectional study. Depression was evaluated with the Center for Epidemiological Studies Depression (CES-D) scale. Antidepressants were documented. Plasma Abeta40 and Abeta42 were measured.

RESULTS

In the absence of CVD, those with depression had lower plasma Abeta42 (median: 13.7 vs. 18.8 pg/mL, p = .003) than those without. Depressed subjects on antidepressant treatment had a lower concentration of plasma Abeta40 (median: 97.8 vs. 133.5 pg/mL, p = .008), but not Abeta42, than those without the treatment. Multivariate logistic regression showed that antidepressant use did not influence the relationship between depression and low plasma Abeta42 (odds ratio = .55; 95% CI = .33, .90; p = .02) after adjusting for confounders, but its use interacted with plasma Abeta40 in the model.

CONCLUSIONS

Lower concentration of plasma Abeta42 is associated with depression in the absence of CVD that is not related to the antidepressant use by those subjects. Prospective studies are needed to determine whether depression associated with low plasma Abeta42 predicts the onset of Alzheimer's disease.

Authors+Show Affiliations

Department of Psychiatry, Tufts-New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17544381

Citation

Sun, Xiaoyan, et al. "Depression, Antidepressants, and Plasma Amyloid Beta (Beta) Peptides in Those Elderly Who Do Not Have Cardiovascular Disease." Biological Psychiatry, vol. 62, no. 12, 2007, pp. 1413-7.
Sun X, Mwamburi DM, Bungay K, et al. Depression, antidepressants, and plasma amyloid beta (Beta) peptides in those elderly who do not have cardiovascular disease. Biol Psychiatry. 2007;62(12):1413-7.
Sun, X., Mwamburi, D. M., Bungay, K., Prasad, J., Yee, J., Lin, Y. M., Liu, T. C., Summergrad, P., Folstein, M., & Qiu, W. Q. (2007). Depression, antidepressants, and plasma amyloid beta (Beta) peptides in those elderly who do not have cardiovascular disease. Biological Psychiatry, 62(12), 1413-7.
Sun X, et al. Depression, Antidepressants, and Plasma Amyloid Beta (Beta) Peptides in Those Elderly Who Do Not Have Cardiovascular Disease. Biol Psychiatry. 2007 Dec 15;62(12):1413-7. PubMed PMID: 17544381.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Depression, antidepressants, and plasma amyloid beta (Beta) peptides in those elderly who do not have cardiovascular disease. AU - Sun,Xiaoyan, AU - Mwamburi,D Mkaya, AU - Bungay,Kathleen, AU - Prasad,Jasmin, AU - Yee,Jacqueline, AU - Lin,Yu-Min, AU - Liu,Timothy C, AU - Summergrad,Paul, AU - Folstein,Marshal, AU - Qiu,Wei Qiao, Y1 - 2007/06/04/ PY - 2006/11/13/received PY - 2006/12/18/revised PY - 2007/01/03/accepted PY - 2007/6/5/pubmed PY - 2008/2/28/medline PY - 2007/6/5/entrez SP - 1413 EP - 7 JF - Biological psychiatry JO - Biol Psychiatry VL - 62 IS - 12 N2 - BACKGROUND: Low plasma amyloid-beta peptide 42 (Abeta42) is associated with depressive symptoms independently of cardiovascular disease (CVD) in the elderly. It is critical to investigate whether antidepressants modify this relationship. METHODS: We evaluated 324 elders without CVD in a cross-sectional study. Depression was evaluated with the Center for Epidemiological Studies Depression (CES-D) scale. Antidepressants were documented. Plasma Abeta40 and Abeta42 were measured. RESULTS: In the absence of CVD, those with depression had lower plasma Abeta42 (median: 13.7 vs. 18.8 pg/mL, p = .003) than those without. Depressed subjects on antidepressant treatment had a lower concentration of plasma Abeta40 (median: 97.8 vs. 133.5 pg/mL, p = .008), but not Abeta42, than those without the treatment. Multivariate logistic regression showed that antidepressant use did not influence the relationship between depression and low plasma Abeta42 (odds ratio = .55; 95% CI = .33, .90; p = .02) after adjusting for confounders, but its use interacted with plasma Abeta40 in the model. CONCLUSIONS: Lower concentration of plasma Abeta42 is associated with depression in the absence of CVD that is not related to the antidepressant use by those subjects. Prospective studies are needed to determine whether depression associated with low plasma Abeta42 predicts the onset of Alzheimer's disease. SN - 1873-2402 UR - https://www.unboundmedicine.com/medline/citation/17544381/Depression_antidepressants_and_plasma_amyloid_beta__Beta__peptides_in_those_elderly_who_do_not_have_cardiovascular_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-3223(07)00010-8 DB - PRIME DP - Unbound Medicine ER -