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Environmental factors and colorectal tumor risk in individuals with hereditary nonpolyposis colorectal cancer.
Clin Gastroenterol Hepatol 2007; 5(6):736-42CG

Abstract

BACKGROUND & AIMS

Individuals with hereditary nonpolyposis colorectal cancer (HNPCC) are at increased risk for colorectal cancer. Environmental factors might play a role in HNPCC-associated carcinogenesis. The aim of this study was to gain insight into the effects of environmental factors on colorectal tumor risk in individuals with HNPCC.

METHODS

We examined associations between dietary factors, cigarette smoking, and HNPCC-associated colorectal tumors in a Dutch case-control study (145 cases, 103 tumor-free controls; all study participants were known or suspected carriers of a germline mutation in one of the DNA mismatch repair genes). We also assessed associations between the various environmental factors and occurrence of adenomatous polyposis coli (APC) mutations in HNPCC-associated polyps in a subset of the study population.

RESULTS

Fruit consumption was inversely associated with ever developing HNPCC-associated colorectal tumors (odds ratio [95% confidence interval] for highest vs lowest tertile, 0.4 [0.2-0.9]; P(trend) = .03); a borderline significant inverse association was observed for dietary fiber intake (0.5 [0.2-1.0]; P(trend) = .06). Cigarette smoking seemed to increase the risk of HNPCC-associated colorectal tumors. Truncating APC mutations were detected in 30 (37.5%) of the 80 available HNPCC-associated polyps; frameshift mutations were most common (73.3%). None of the evaluated environmental factors was distinctively associated with a specific APC status of the polyps.

CONCLUSIONS

Our data suggest that fruit consumption and dietary fiber intake might decrease the risk of colorectal tumors in individuals with HNPCC, whereas cigarette smoking might increase the risk of HNPCC-associated colorectal tumors. The observed associations support the hypothesis that HNPCC-associated outcomes might be modified by environmental factors.

Authors+Show Affiliations

Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17544999

Citation

Diergaarde, Brenda, et al. "Environmental Factors and Colorectal Tumor Risk in Individuals With Hereditary Nonpolyposis Colorectal Cancer." Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association, vol. 5, no. 6, 2007, pp. 736-42.
Diergaarde B, Braam H, Vasen HF, et al. Environmental factors and colorectal tumor risk in individuals with hereditary nonpolyposis colorectal cancer. Clin Gastroenterol Hepatol. 2007;5(6):736-42.
Diergaarde, B., Braam, H., Vasen, H. F., Nagengast, F. M., van Muijen, G. N., Kok, F. J., & Kampman, E. (2007). Environmental factors and colorectal tumor risk in individuals with hereditary nonpolyposis colorectal cancer. Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association, 5(6), pp. 736-42.
Diergaarde B, et al. Environmental Factors and Colorectal Tumor Risk in Individuals With Hereditary Nonpolyposis Colorectal Cancer. Clin Gastroenterol Hepatol. 2007;5(6):736-42. PubMed PMID: 17544999.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Environmental factors and colorectal tumor risk in individuals with hereditary nonpolyposis colorectal cancer. AU - Diergaarde,Brenda, AU - Braam,Hanneke, AU - Vasen,Hans F, AU - Nagengast,Fokko M, AU - van Muijen,Goos N P, AU - Kok,Frans J, AU - Kampman,Ellen, PY - 2007/6/5/pubmed PY - 2007/12/6/medline PY - 2007/6/5/entrez SP - 736 EP - 42 JF - Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association JO - Clin. Gastroenterol. Hepatol. VL - 5 IS - 6 N2 - BACKGROUND & AIMS: Individuals with hereditary nonpolyposis colorectal cancer (HNPCC) are at increased risk for colorectal cancer. Environmental factors might play a role in HNPCC-associated carcinogenesis. The aim of this study was to gain insight into the effects of environmental factors on colorectal tumor risk in individuals with HNPCC. METHODS: We examined associations between dietary factors, cigarette smoking, and HNPCC-associated colorectal tumors in a Dutch case-control study (145 cases, 103 tumor-free controls; all study participants were known or suspected carriers of a germline mutation in one of the DNA mismatch repair genes). We also assessed associations between the various environmental factors and occurrence of adenomatous polyposis coli (APC) mutations in HNPCC-associated polyps in a subset of the study population. RESULTS: Fruit consumption was inversely associated with ever developing HNPCC-associated colorectal tumors (odds ratio [95% confidence interval] for highest vs lowest tertile, 0.4 [0.2-0.9]; P(trend) = .03); a borderline significant inverse association was observed for dietary fiber intake (0.5 [0.2-1.0]; P(trend) = .06). Cigarette smoking seemed to increase the risk of HNPCC-associated colorectal tumors. Truncating APC mutations were detected in 30 (37.5%) of the 80 available HNPCC-associated polyps; frameshift mutations were most common (73.3%). None of the evaluated environmental factors was distinctively associated with a specific APC status of the polyps. CONCLUSIONS: Our data suggest that fruit consumption and dietary fiber intake might decrease the risk of colorectal tumors in individuals with HNPCC, whereas cigarette smoking might increase the risk of HNPCC-associated colorectal tumors. The observed associations support the hypothesis that HNPCC-associated outcomes might be modified by environmental factors. SN - 1542-7714 UR - https://www.unboundmedicine.com/medline/citation/17544999/Environmental_factors_and_colorectal_tumor_risk_in_individuals_with_hereditary_nonpolyposis_colorectal_cancer_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1542-3565(07)00211-X DB - PRIME DP - Unbound Medicine ER -