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[Avastin combined with cisplan inhibits malignant ascites production in nude mice bearing transplanted ovary carcinoma with high VEGF expression].
Nan Fang Yi Ke Da Xue Xue Bao. 2007 May; 27(5):647-9.NF

Abstract

OBJECTIVE

To establish a nude mouse model of malignant ascites with human ovarian carcinoma cell line OVCAR3 which highly expresses VEGF and evaluate the therapeutic of Avastin combined with cisplan.

METHODS

Forty-eight nude mice with malignant ascites resulting from intraperitoneal transplantation of human ovarian carcinoma cell line OVCAR3 were treated with intraperitoneal injection of Avastin, cisplan, their combination, and PBS, respectively, to observe the effect on ascites development, VEGF content in the ascites, peritoneal permeability, development of new vessels and number of tumor cells in the ascites.

RESULTS

Avastin obviously inhibited ascites accumulation and peritoneal capillary permeability, reduced VEGF protein level and microvascular density in the tumor tissues and the number of red cells and tumor cells in the malignant ascites, and prolonged the survival of the mice. The combination of Avastin and cisplan further enhanced the therapeutic efficacy of Avastin.

CONCLUSION

The bio-chemotherapeutic strategy with Avastin combined with cisplan can be a promising method for treatment of malignant ascites.

Authors+Show Affiliations

Center of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. cyj7728 @163.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

17545079

Citation

Cai, Yan-jun, et al. "[Avastin Combined With Cisplan Inhibits Malignant Ascites Production in Nude Mice Bearing Transplanted Ovary Carcinoma With High VEGF Expression]." Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University, vol. 27, no. 5, 2007, pp. 647-9.
Cai YJ, Zheng DY, Luo RC, et al. [Avastin combined with cisplan inhibits malignant ascites production in nude mice bearing transplanted ovary carcinoma with high VEGF expression]. Nan Fang Yi Ke Da Xue Xue Bao. 2007;27(5):647-9.
Cai, Y. J., Zheng, D. Y., Luo, R. C., Chen, J. Z., Li, A. M., Xi, J. L., & Ding, X. M. (2007). [Avastin combined with cisplan inhibits malignant ascites production in nude mice bearing transplanted ovary carcinoma with high VEGF expression]. Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University, 27(5), 647-9.
Cai YJ, et al. [Avastin Combined With Cisplan Inhibits Malignant Ascites Production in Nude Mice Bearing Transplanted Ovary Carcinoma With High VEGF Expression]. Nan Fang Yi Ke Da Xue Xue Bao. 2007;27(5):647-9. PubMed PMID: 17545079.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Avastin combined with cisplan inhibits malignant ascites production in nude mice bearing transplanted ovary carcinoma with high VEGF expression]. AU - Cai,Yan-jun, AU - Zheng,Da-yong, AU - Luo,Rong-cheng, AU - Chen,Jin-zhang, AU - Li,Ai-ming, AU - Xi,Jing-le, AU - Ding,Xue-mei, PY - 2007/6/5/pubmed PY - 2010/8/17/medline PY - 2007/6/5/entrez SP - 647 EP - 9 JF - Nan fang yi ke da xue xue bao = Journal of Southern Medical University JO - Nan Fang Yi Ke Da Xue Xue Bao VL - 27 IS - 5 N2 - OBJECTIVE: To establish a nude mouse model of malignant ascites with human ovarian carcinoma cell line OVCAR3 which highly expresses VEGF and evaluate the therapeutic of Avastin combined with cisplan. METHODS: Forty-eight nude mice with malignant ascites resulting from intraperitoneal transplantation of human ovarian carcinoma cell line OVCAR3 were treated with intraperitoneal injection of Avastin, cisplan, their combination, and PBS, respectively, to observe the effect on ascites development, VEGF content in the ascites, peritoneal permeability, development of new vessels and number of tumor cells in the ascites. RESULTS: Avastin obviously inhibited ascites accumulation and peritoneal capillary permeability, reduced VEGF protein level and microvascular density in the tumor tissues and the number of red cells and tumor cells in the malignant ascites, and prolonged the survival of the mice. The combination of Avastin and cisplan further enhanced the therapeutic efficacy of Avastin. CONCLUSION: The bio-chemotherapeutic strategy with Avastin combined with cisplan can be a promising method for treatment of malignant ascites. SN - 1673-4254 UR - https://www.unboundmedicine.com/medline/citation/17545079/[Avastin_combined_with_cisplan_inhibits_malignant_ascites_production_in_nude_mice_bearing_transplanted_ovary_carcinoma_with_high_VEGF_expression]_ L2 - https://medlineplus.gov/ovariancancer.html DB - PRIME DP - Unbound Medicine ER -