Tags

Type your tag names separated by a space and hit enter

W-7 (a calmodulin antagonist) inhibits carrageenan-induced paw edema in intact and adrenalectomized rats.
Pak J Pharm Sci. 2007 Jul; 20(3):195-9.PJ

Abstract

The aim of present study was to investigate the effect of W-7, a calmodulin antagonist, on carrageenan-induced rat's paw edema. W-7(50 microMol/kg) was given intraperitoneally synchronous with the intraplantar injection of 0.1 ml of 0.5% carrageenan solution. After four hours, paw edema was assessed by calculating the paw volume changes which measured by hydroplethysmometer. In adrenalectomized rats, both adrenal glands were removed. Treatment of animals with W-7 reduced carrageenan-induced paw edema by 50%. In adrenalectomized rats, W-7 was also effective in reduction of paw edema (52%). There was no significant difference between the effect of W-7 in adrenalectomized and control animals. Our findings suggest that W-7 as a calmodulin inhibitor reduce carrageenan-induced paw edema and the inhibitory effect of W-7 on edema formation appears not to be dependent on adrenal function.

Authors+Show Affiliations

Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran. khaksar38@yahoo.co.ukNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17545103

Citation

Khaksari, Mohammad, et al. "W-7 (a Calmodulin Antagonist) Inhibits Carrageenan-induced Paw Edema in Intact and Adrenalectomized Rats." Pakistan Journal of Pharmaceutical Sciences, vol. 20, no. 3, 2007, pp. 195-9.
Khaksari M, Shamsizadeh A, Azarang A, et al. W-7 (a calmodulin antagonist) inhibits carrageenan-induced paw edema in intact and adrenalectomized rats. Pak J Pharm Sci. 2007;20(3):195-9.
Khaksari, M., Shamsizadeh, A., Azarang, A., & Mahmoodi, M. (2007). W-7 (a calmodulin antagonist) inhibits carrageenan-induced paw edema in intact and adrenalectomized rats. Pakistan Journal of Pharmaceutical Sciences, 20(3), 195-9.
Khaksari M, et al. W-7 (a Calmodulin Antagonist) Inhibits Carrageenan-induced Paw Edema in Intact and Adrenalectomized Rats. Pak J Pharm Sci. 2007;20(3):195-9. PubMed PMID: 17545103.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - W-7 (a calmodulin antagonist) inhibits carrageenan-induced paw edema in intact and adrenalectomized rats. AU - Khaksari,Mohammad, AU - Shamsizadeh,Ali, AU - Azarang,Afrooz, AU - Mahmoodi,Mehdi, PY - 2007/6/5/pubmed PY - 2007/9/26/medline PY - 2007/6/5/entrez SP - 195 EP - 9 JF - Pakistan journal of pharmaceutical sciences JO - Pak J Pharm Sci VL - 20 IS - 3 N2 - The aim of present study was to investigate the effect of W-7, a calmodulin antagonist, on carrageenan-induced rat's paw edema. W-7(50 microMol/kg) was given intraperitoneally synchronous with the intraplantar injection of 0.1 ml of 0.5% carrageenan solution. After four hours, paw edema was assessed by calculating the paw volume changes which measured by hydroplethysmometer. In adrenalectomized rats, both adrenal glands were removed. Treatment of animals with W-7 reduced carrageenan-induced paw edema by 50%. In adrenalectomized rats, W-7 was also effective in reduction of paw edema (52%). There was no significant difference between the effect of W-7 in adrenalectomized and control animals. Our findings suggest that W-7 as a calmodulin inhibitor reduce carrageenan-induced paw edema and the inhibitory effect of W-7 on edema formation appears not to be dependent on adrenal function. SN - 1011-601X UR - https://www.unboundmedicine.com/medline/citation/17545103/W_7__a_calmodulin_antagonist__inhibits_carrageenan_induced_paw_edema_in_intact_and_adrenalectomized_rats_ L2 - https://medlineplus.gov/edema.html DB - PRIME DP - Unbound Medicine ER -