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Matrix-assisted laser desorption/ionization mass spectrometry of polysaccharides with 2',4',6'-trihydroxyacetophenone as matrix.
Rapid Commun Mass Spectrom. 2007; 21(13):2137-46.RC

Abstract

So far, there have been only a few matrices reported for detection of polysaccharides with molecular weight higher than 3000 Daltons by matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS). In this work, we found that 2',4',6'-trihydroxyacetophenone (THAP) is a good matrix for MALDI time-of-flight MS analysis of polysaccharides with broad mass range. Large polysaccharides, dextrans, glycoproteins and polysialic acids have been successfully detected by MALDI-MS with THAP as matrix.

Authors+Show Affiliations

Hsu NY
Department of Chemistry, National Taiwan University, Taipei, Taiwan.
Yang WB
No affiliation info available
Wong CH
No affiliation info available
Lee YC
No affiliation info available
Lee RT
No affiliation info available
Wang YS
No affiliation info available
Chen CH
No affiliation info available

MeSH

AcetophenonesMass SpectrometryMolecular StructurePolysaccharidesSpectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17546658

Citation

Hsu, Nien-Yeen, et al. "Matrix-assisted Laser Desorption/ionization Mass Spectrometry of Polysaccharides With 2',4',6'-trihydroxyacetophenone as Matrix." Rapid Communications in Mass Spectrometry : RCM, vol. 21, no. 13, 2007, pp. 2137-46.
Hsu NY, Yang WB, Wong CH, et al. Matrix-assisted laser desorption/ionization mass spectrometry of polysaccharides with 2',4',6'-trihydroxyacetophenone as matrix. Rapid Commun Mass Spectrom. 2007;21(13):2137-46.
Hsu, N. Y., Yang, W. B., Wong, C. H., Lee, Y. C., Lee, R. T., Wang, Y. S., & Chen, C. H. (2007). Matrix-assisted laser desorption/ionization mass spectrometry of polysaccharides with 2',4',6'-trihydroxyacetophenone as matrix. Rapid Communications in Mass Spectrometry : RCM, 21(13), 2137-46.
Hsu NY, et al. Matrix-assisted Laser Desorption/ionization Mass Spectrometry of Polysaccharides With 2',4',6'-trihydroxyacetophenone as Matrix. Rapid Commun Mass Spectrom. 2007;21(13):2137-46. PubMed PMID: 17546658.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Matrix-assisted laser desorption/ionization mass spectrometry of polysaccharides with 2',4',6'-trihydroxyacetophenone as matrix. AU - Hsu,Nien-Yeen, AU - Yang,Wen-Bin, AU - Wong,Chi-Huey, AU - Lee,Yuan-Chuan, AU - Lee,Reiko T, AU - Wang,Yi-Sheng, AU - Chen,Chung-Hsuan, PY - 2007/6/5/pubmed PY - 2007/8/3/medline PY - 2007/6/5/entrez SP - 2137 EP - 46 JF - Rapid communications in mass spectrometry : RCM JO - Rapid Commun Mass Spectrom VL - 21 IS - 13 N2 - So far, there have been only a few matrices reported for detection of polysaccharides with molecular weight higher than 3000 Daltons by matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS). In this work, we found that 2',4',6'-trihydroxyacetophenone (THAP) is a good matrix for MALDI time-of-flight MS analysis of polysaccharides with broad mass range. Large polysaccharides, dextrans, glycoproteins and polysialic acids have been successfully detected by MALDI-MS with THAP as matrix. SN - 0951-4198 UR - https://www.unboundmedicine.com/medline/citation/17546658/Matrix_assisted_laser_desorption/ionization_mass_spectrometry_of_polysaccharides_with_2'4'6'_trihydroxyacetophenone_as_matrix_ L2 - https://doi.org/10.1002/rcm.3072 DB - PRIME DP - Unbound Medicine ER -
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