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Free triiodothyronine and thyroid stimulating hormone are directly associated with waist circumference, independently of insulin resistance, metabolic parameters and blood pressure in overweight and obese women.
Clin Endocrinol (Oxf). 2007 Aug; 67(2):265-9.CE

Abstract

OBJECTIVE

To examine whether obesity, body fat distribution and insulin resistance have an independent effect on serum TSH and free thyroid hormones (FT3 and FT4) in a cohort of euthyroid women, represented by overweight and obese patients.

DESIGN AND PATIENTS

A total of 201 women, aged 18-68 years, with body mass index (BMI) > or = 25.0 kg/m(2) and TSH levels < 4.0 mU/l were investigated.

MEASUREMENTS

Fasting TSH, FT3, FT4, insulin, glucose, and serum lipid concentrations, and the level of insulin resistance, estimated by the homeostasis model assessment for insulin resistance (HOMA-IR). Waist circumference was measured as an indirect parameter of central fat accumulation.

RESULTS

FT3 was directly associated with BMI (P < 0.01) and waist circumference (P < 0.01), and negatively correlated with age (P < 0.001). FT4 was negatively associated with HOMA-IR (P < 0.05) and fasting insulin levels (P < 0.05). TSH was positively correlated with waist circumference (P < 0.05) and negatively associated with age (P < 0.05). When multiple regression analysis was performed with FT3 as the dependent variable, and waist circumference, HOMA-IR, blood pressure levels and serum lipid concentrations as independent variables, FT3 maintained an independent association only with waist circumference (positive, P < 0.05) and age (negative, P < 0.001). When multiple regression analysis was performed with TSH as the dependent variable, and the above parameters as independent variables, TSH maintained an independent association only with waist circumference (positive, P < 0.05) and age (negative, P < 0.05). By contrast, when multiple regression analysis was performed with FT4 as the dependent variable, FT4 did not maintain an independent association with any of the independent parameters.

CONCLUSIONS

Progressive central fat accumulation is associated with an increase in both FT3 and TSH serum levels, independently of insulin sensitivity, metabolic parameters and blood pressure. These results suggest that (1) progressive central fat accumulation is associated with a parallel increase in FT3 levels, possibly as an adaptive thermogenic phenomenon, and (2) the control of TSH secretion by free thyroid hormones is possibly impaired in obesity.

Authors+Show Affiliations

Internal Medicine, Endocrinology, and Metabolic Diseases, Department of Emergency and Organ Transplantation, School of Medicine, University of Bari, Via Putignani 236, 70122 Bari, Italy. g.depergola@endo.uniba.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17547687

Citation

De Pergola, G, et al. "Free Triiodothyronine and Thyroid Stimulating Hormone Are Directly Associated With Waist Circumference, Independently of Insulin Resistance, Metabolic Parameters and Blood Pressure in Overweight and Obese Women." Clinical Endocrinology, vol. 67, no. 2, 2007, pp. 265-9.
De Pergola G, Ciampolillo A, Paolotti S, et al. Free triiodothyronine and thyroid stimulating hormone are directly associated with waist circumference, independently of insulin resistance, metabolic parameters and blood pressure in overweight and obese women. Clin Endocrinol (Oxf). 2007;67(2):265-9.
De Pergola, G., Ciampolillo, A., Paolotti, S., Trerotoli, P., & Giorgino, R. (2007). Free triiodothyronine and thyroid stimulating hormone are directly associated with waist circumference, independently of insulin resistance, metabolic parameters and blood pressure in overweight and obese women. Clinical Endocrinology, 67(2), 265-9.
De Pergola G, et al. Free Triiodothyronine and Thyroid Stimulating Hormone Are Directly Associated With Waist Circumference, Independently of Insulin Resistance, Metabolic Parameters and Blood Pressure in Overweight and Obese Women. Clin Endocrinol (Oxf). 2007;67(2):265-9. PubMed PMID: 17547687.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Free triiodothyronine and thyroid stimulating hormone are directly associated with waist circumference, independently of insulin resistance, metabolic parameters and blood pressure in overweight and obese women. AU - De Pergola,G, AU - Ciampolillo,A, AU - Paolotti,S, AU - Trerotoli,P, AU - Giorgino,R, Y1 - 2007/06/04/ PY - 2007/6/6/pubmed PY - 2008/1/11/medline PY - 2007/6/6/entrez SP - 265 EP - 9 JF - Clinical endocrinology JO - Clin Endocrinol (Oxf) VL - 67 IS - 2 N2 - OBJECTIVE: To examine whether obesity, body fat distribution and insulin resistance have an independent effect on serum TSH and free thyroid hormones (FT3 and FT4) in a cohort of euthyroid women, represented by overweight and obese patients. DESIGN AND PATIENTS: A total of 201 women, aged 18-68 years, with body mass index (BMI) > or = 25.0 kg/m(2) and TSH levels < 4.0 mU/l were investigated. MEASUREMENTS: Fasting TSH, FT3, FT4, insulin, glucose, and serum lipid concentrations, and the level of insulin resistance, estimated by the homeostasis model assessment for insulin resistance (HOMA-IR). Waist circumference was measured as an indirect parameter of central fat accumulation. RESULTS: FT3 was directly associated with BMI (P < 0.01) and waist circumference (P < 0.01), and negatively correlated with age (P < 0.001). FT4 was negatively associated with HOMA-IR (P < 0.05) and fasting insulin levels (P < 0.05). TSH was positively correlated with waist circumference (P < 0.05) and negatively associated with age (P < 0.05). When multiple regression analysis was performed with FT3 as the dependent variable, and waist circumference, HOMA-IR, blood pressure levels and serum lipid concentrations as independent variables, FT3 maintained an independent association only with waist circumference (positive, P < 0.05) and age (negative, P < 0.001). When multiple regression analysis was performed with TSH as the dependent variable, and the above parameters as independent variables, TSH maintained an independent association only with waist circumference (positive, P < 0.05) and age (negative, P < 0.05). By contrast, when multiple regression analysis was performed with FT4 as the dependent variable, FT4 did not maintain an independent association with any of the independent parameters. CONCLUSIONS: Progressive central fat accumulation is associated with an increase in both FT3 and TSH serum levels, independently of insulin sensitivity, metabolic parameters and blood pressure. These results suggest that (1) progressive central fat accumulation is associated with a parallel increase in FT3 levels, possibly as an adaptive thermogenic phenomenon, and (2) the control of TSH secretion by free thyroid hormones is possibly impaired in obesity. SN - 0300-0664 UR - https://www.unboundmedicine.com/medline/citation/17547687/Free_triiodothyronine_and_thyroid_stimulating_hormone_are_directly_associated_with_waist_circumference_independently_of_insulin_resistance_metabolic_parameters_and_blood_pressure_in_overweight_and_obese_women_ L2 - https://doi.org/10.1111/j.1365-2265.2007.02874.x DB - PRIME DP - Unbound Medicine ER -