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Electroacupuncture combined with clomipramine enhances antidepressant effect in rodents.
Neurosci Lett. 2007 Jun 21; 421(1):5-9.NL

Abstract

The present study was designed to evaluate the antidepressant effect of electroacupuncture (EA) and the potential additive or synergistic effects of EA and clomipramine (CLO, a tricyclic antidepressant) in the mouse forced swimming test (FST) and chronic mild stress (CMS) induced depression-model rats. The FST is an antidepressant screening procedure performed initially to observe the immediate effects of EA and/or CLO on the immobility time. CLO (2.5, 5, 10, 20 and 60mg/kg intraperitoneally) were administered at 23, 6 and 1h respectively prior to each test. EA was given at the 'Bai-Hui' (Du 20) and unilateral 'An-Mian' (EX 17) acupoints 1h before each test. Immobility time was significantly reduced by EA and CLO at 2.5, 5, 10, 20 or 60mg/kg, respectively. EA combined with 2.5mg/kg CLO exhibited additive effects on the immobility time. In addition, rats were exposed chronically (1st-11th week) to a variety of mild unpredictable stressors. Depressed mood and anhedonia were recognized as a decrease in sucrose intake in the CMS rats. CLO at 2.5, 5mg/kg and EA at the same acupoints and parameters were administrated on the CMS rats once every other day for 6 weeks (5th-11th week). The intake of 1% sucrose solution was reduced by CMS, which was restored to normal level after 6 weeks treatment with 5mg/kg CLO or EA combined with 2.5mg/kg CLO. However, neither the sucrose intake nor the sucrose preference in the depressive rats was significantly changed by the treatment with EA or 2.5mg/kg CLO alone. These results demonstrated that EA combined with CLO at low doses has an additive or synergistic antidepressant action, and this combination may provide an effective strategy for depression management.

Authors+Show Affiliations

Department of Integrative Medicine and Neurobiology, Institute of Acupuncture Research (WHO Collaborating Center for Traditional Medicine), Shanghai Medical College, Fudan University, Shanghai 200032, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17548153

Citation

Yu, Jin, et al. "Electroacupuncture Combined With Clomipramine Enhances Antidepressant Effect in Rodents." Neuroscience Letters, vol. 421, no. 1, 2007, pp. 5-9.
Yu J, Liu Q, Wang YQ, et al. Electroacupuncture combined with clomipramine enhances antidepressant effect in rodents. Neurosci Lett. 2007;421(1):5-9.
Yu, J., Liu, Q., Wang, Y. Q., Wang, J., Li, X. Y., Cao, X. D., & Wu, G. C. (2007). Electroacupuncture combined with clomipramine enhances antidepressant effect in rodents. Neuroscience Letters, 421(1), 5-9.
Yu J, et al. Electroacupuncture Combined With Clomipramine Enhances Antidepressant Effect in Rodents. Neurosci Lett. 2007 Jun 21;421(1):5-9. PubMed PMID: 17548153.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Electroacupuncture combined with clomipramine enhances antidepressant effect in rodents. AU - Yu,Jin, AU - Liu,Qiong, AU - Wang,Yan-Qing, AU - Wang,Jun, AU - Li,Xiao-Yan, AU - Cao,Xiao-Ding, AU - Wu,Gen-Cheng, Y1 - 2007/02/24/ PY - 2006/07/11/received PY - 2006/12/14/revised PY - 2007/02/19/accepted PY - 2007/6/6/pubmed PY - 2007/9/1/medline PY - 2007/6/6/entrez SP - 5 EP - 9 JF - Neuroscience letters JO - Neurosci. Lett. VL - 421 IS - 1 N2 - The present study was designed to evaluate the antidepressant effect of electroacupuncture (EA) and the potential additive or synergistic effects of EA and clomipramine (CLO, a tricyclic antidepressant) in the mouse forced swimming test (FST) and chronic mild stress (CMS) induced depression-model rats. The FST is an antidepressant screening procedure performed initially to observe the immediate effects of EA and/or CLO on the immobility time. CLO (2.5, 5, 10, 20 and 60mg/kg intraperitoneally) were administered at 23, 6 and 1h respectively prior to each test. EA was given at the 'Bai-Hui' (Du 20) and unilateral 'An-Mian' (EX 17) acupoints 1h before each test. Immobility time was significantly reduced by EA and CLO at 2.5, 5, 10, 20 or 60mg/kg, respectively. EA combined with 2.5mg/kg CLO exhibited additive effects on the immobility time. In addition, rats were exposed chronically (1st-11th week) to a variety of mild unpredictable stressors. Depressed mood and anhedonia were recognized as a decrease in sucrose intake in the CMS rats. CLO at 2.5, 5mg/kg and EA at the same acupoints and parameters were administrated on the CMS rats once every other day for 6 weeks (5th-11th week). The intake of 1% sucrose solution was reduced by CMS, which was restored to normal level after 6 weeks treatment with 5mg/kg CLO or EA combined with 2.5mg/kg CLO. However, neither the sucrose intake nor the sucrose preference in the depressive rats was significantly changed by the treatment with EA or 2.5mg/kg CLO alone. These results demonstrated that EA combined with CLO at low doses has an additive or synergistic antidepressant action, and this combination may provide an effective strategy for depression management. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/17548153/Electroacupuncture_combined_with_clomipramine_enhances_antidepressant_effect_in_rodents_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(07)00237-6 DB - PRIME DP - Unbound Medicine ER -