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Prevalence of Helicobacter pylori vacA, cagA, cagE, iceA and babA2 genotypes in Thai dyspeptic patients.
Int J Infect Dis. 2008 Jan; 12(1):30-6.IJ

Abstract

OBJECTIVES

To investigate the prevalence of the vacA, cagA, cagE, iceA, and babA2 genotypes in Helicobacter pylori strains isolated from Thai dyspeptic patients, and to determine whether any correlation exists between these genotypes and clinical manifestations.

METHODS

Helicobacter pylori was examined in 112 patients (62 with non-ulcer dyspepsia (gastritis), 34 with peptic ulcer disease, and 16 with gastric cancer (GCA)), detected by culture or direct detection from gastric biopsies. Allelic variants of the vacA, cagA, cagE, iceA, and babA2 genotypes were identified by using the polymerase chain reaction.

RESULTS

The positive rates for the vacAs1, vacAs2, cagA, cagE, iceA1, iceA2, and babA2 genes in H. pylori of dyspeptic patients were 100%, 0%, 98.2%, 88.4%, 45.5%, 33.1%, and 92%, respectively. The allelic variant vacAs1m1 was more prevalent (58%) than vacAs1m2 (42%). The cagA and cagE genes were commonly found together (87.5%). The most predominant genotypes were vacAs1m1, cagA, cagE, iceA1, and babA2. The various genes alone or in combination had no statistically significant association with the clinical outcomes (p>0.05).

CONCLUSION

Neither single gene nor combination of vacA, cagA, cagE, iceA, and babA2 genes was significantly helpful in predicting the clinical outcome of H. pylori infection in Thai patients. The high prevalence of these genes in H. pylori isolated from Thai patient groups suggests that H. pylori strains are geographically dependent.

Authors+Show Affiliations

Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand. chariya@kku.ac.thNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17548220

Citation

Chomvarin, Chariya, et al. "Prevalence of Helicobacter Pylori vacA, cagA, cagE, iceA and babA2 Genotypes in Thai Dyspeptic Patients." International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases, vol. 12, no. 1, 2008, pp. 30-6.
Chomvarin C, Namwat W, Chaicumpar K, et al. Prevalence of Helicobacter pylori vacA, cagA, cagE, iceA and babA2 genotypes in Thai dyspeptic patients. Int J Infect Dis. 2008;12(1):30-6.
Chomvarin, C., Namwat, W., Chaicumpar, K., Mairiang, P., Sangchan, A., Sripa, B., Tor-Udom, S., & Vilaichone, R. K. (2008). Prevalence of Helicobacter pylori vacA, cagA, cagE, iceA and babA2 genotypes in Thai dyspeptic patients. International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases, 12(1), 30-6.
Chomvarin C, et al. Prevalence of Helicobacter Pylori vacA, cagA, cagE, iceA and babA2 Genotypes in Thai Dyspeptic Patients. Int J Infect Dis. 2008;12(1):30-6. PubMed PMID: 17548220.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of Helicobacter pylori vacA, cagA, cagE, iceA and babA2 genotypes in Thai dyspeptic patients. AU - Chomvarin,Chariya, AU - Namwat,Wises, AU - Chaicumpar,Kunyaluk, AU - Mairiang,Pisaln, AU - Sangchan,Apichat, AU - Sripa,Banchob, AU - Tor-Udom,Siripen, AU - Vilaichone,Ratha-Khon, Y1 - 2007/06/04/ PY - 2006/08/24/received PY - 2007/02/28/revised PY - 2007/03/05/accepted PY - 2007/6/6/pubmed PY - 2008/4/9/medline PY - 2007/6/6/entrez SP - 30 EP - 6 JF - International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases JO - Int J Infect Dis VL - 12 IS - 1 N2 - OBJECTIVES: To investigate the prevalence of the vacA, cagA, cagE, iceA, and babA2 genotypes in Helicobacter pylori strains isolated from Thai dyspeptic patients, and to determine whether any correlation exists between these genotypes and clinical manifestations. METHODS: Helicobacter pylori was examined in 112 patients (62 with non-ulcer dyspepsia (gastritis), 34 with peptic ulcer disease, and 16 with gastric cancer (GCA)), detected by culture or direct detection from gastric biopsies. Allelic variants of the vacA, cagA, cagE, iceA, and babA2 genotypes were identified by using the polymerase chain reaction. RESULTS: The positive rates for the vacAs1, vacAs2, cagA, cagE, iceA1, iceA2, and babA2 genes in H. pylori of dyspeptic patients were 100%, 0%, 98.2%, 88.4%, 45.5%, 33.1%, and 92%, respectively. The allelic variant vacAs1m1 was more prevalent (58%) than vacAs1m2 (42%). The cagA and cagE genes were commonly found together (87.5%). The most predominant genotypes were vacAs1m1, cagA, cagE, iceA1, and babA2. The various genes alone or in combination had no statistically significant association with the clinical outcomes (p>0.05). CONCLUSION: Neither single gene nor combination of vacA, cagA, cagE, iceA, and babA2 genes was significantly helpful in predicting the clinical outcome of H. pylori infection in Thai patients. The high prevalence of these genes in H. pylori isolated from Thai patient groups suggests that H. pylori strains are geographically dependent. SN - 1201-9712 UR - https://www.unboundmedicine.com/medline/citation/17548220/Prevalence_of_Helicobacter_pylori_vacA_cagA_cagE_iceA_and_babA2_genotypes_in_Thai_dyspeptic_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1201-9712(07)00074-4 DB - PRIME DP - Unbound Medicine ER -