Tags

Type your tag names separated by a space and hit enter

Low-positive antibody titer against Helicobacter pylori cytotoxin-associated gene A (CagA) may predict future gastric cancer better than simple seropositivity against H. pylori CagA or against H. pylori.

Abstract

BACKGROUND

To investigate the IgG antibody titer against Helicobacter pylori CagA as a risk factor for future noncardia gastric cancer.

METHODS

A nested case-control study was done in the longitudinal cohort of atomic bomb survivors using stored sera before diagnosis (mean, 2.3 years). Enrolled were 299 cancer cases and 3 controls per case selected from cohort members matched on age, gender, city, and time and type of serum storage and countermatched on radiation dose.

RESULTS

H. pylori IgG seropositive with CagA IgG low titer was the strongest risk factor for noncardia gastric cancer [relative risk (RR), 3.9; 95% confidence interval (95% CI), 2.1-7.0; P < 0.001], especially for intestinal-type tumor (RR, 9.9, 95% CI, 3.5-27.4; P < 0.001), compared with other risk factors, H. pylori IgG seropositive with CagA IgG negative (RR, 2.2; 95% CI, 1.3-3.9; P = 0.0052), H. pylori IgG seropositive with CagA IgG high titer (RR, 2.0; 95% CI, 1.3-3.2; P = 0.0022), chronic atrophic gastritis (RR, 2.4; 95% CI, 1.8-3.3; P < 0.001), current smoking (RR, 2.3; 95% CI, 1.4-3.5; P < 0.001), or radiation dose (RR, 2.1; 95% CI, 1.2-3.1; P = 0.00193). Current smoking showed significantly higher risk for diffuse-type than intestinal-type tumors (P = 0.0372). Radiation risk was significant only for nonsmokers, all noncardia, and diffuse-type gastric cancers.

CONCLUSIONS

A low CagA IgG titer is a useful biomarker to identify a high-risk group and it also provides a clue to understanding host-pathogen interaction.

Authors+Show Affiliations

Department of Clinical Studies, Radiation Effects Research Foundation, Hiroshima, Japan. gsuzuki@niph.go.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17548689

Citation

Suzuki, Gen, et al. "Low-positive Antibody Titer Against Helicobacter Pylori Cytotoxin-associated Gene a (CagA) May Predict Future Gastric Cancer Better Than Simple Seropositivity Against H. Pylori CagA or Against H. Pylori." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 16, no. 6, 2007, pp. 1224-8.
Suzuki G, Cullings H, Fujiwara S, et al. Low-positive antibody titer against Helicobacter pylori cytotoxin-associated gene A (CagA) may predict future gastric cancer better than simple seropositivity against H. pylori CagA or against H. pylori. Cancer Epidemiol Biomarkers Prev. 2007;16(6):1224-8.
Suzuki, G., Cullings, H., Fujiwara, S., Hattori, N., Matsuura, S., Hakoda, M., ... Tahara, E. (2007). Low-positive antibody titer against Helicobacter pylori cytotoxin-associated gene A (CagA) may predict future gastric cancer better than simple seropositivity against H. pylori CagA or against H. pylori. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 16(6), pp. 1224-8.
Suzuki G, et al. Low-positive Antibody Titer Against Helicobacter Pylori Cytotoxin-associated Gene a (CagA) May Predict Future Gastric Cancer Better Than Simple Seropositivity Against H. Pylori CagA or Against H. Pylori. Cancer Epidemiol Biomarkers Prev. 2007;16(6):1224-8. PubMed PMID: 17548689.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low-positive antibody titer against Helicobacter pylori cytotoxin-associated gene A (CagA) may predict future gastric cancer better than simple seropositivity against H. pylori CagA or against H. pylori. AU - Suzuki,Gen, AU - Cullings,Harry, AU - Fujiwara,Saeko, AU - Hattori,Nobuaki, AU - Matsuura,Shinsuke, AU - Hakoda,Masayuki, AU - Akahoshi,Masazumi, AU - Kodama,Kazunori, AU - Tahara,Eiichi, PY - 2007/6/6/pubmed PY - 2007/10/4/medline PY - 2007/6/6/entrez SP - 1224 EP - 8 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 16 IS - 6 N2 - BACKGROUND: To investigate the IgG antibody titer against Helicobacter pylori CagA as a risk factor for future noncardia gastric cancer. METHODS: A nested case-control study was done in the longitudinal cohort of atomic bomb survivors using stored sera before diagnosis (mean, 2.3 years). Enrolled were 299 cancer cases and 3 controls per case selected from cohort members matched on age, gender, city, and time and type of serum storage and countermatched on radiation dose. RESULTS: H. pylori IgG seropositive with CagA IgG low titer was the strongest risk factor for noncardia gastric cancer [relative risk (RR), 3.9; 95% confidence interval (95% CI), 2.1-7.0; P < 0.001], especially for intestinal-type tumor (RR, 9.9, 95% CI, 3.5-27.4; P < 0.001), compared with other risk factors, H. pylori IgG seropositive with CagA IgG negative (RR, 2.2; 95% CI, 1.3-3.9; P = 0.0052), H. pylori IgG seropositive with CagA IgG high titer (RR, 2.0; 95% CI, 1.3-3.2; P = 0.0022), chronic atrophic gastritis (RR, 2.4; 95% CI, 1.8-3.3; P < 0.001), current smoking (RR, 2.3; 95% CI, 1.4-3.5; P < 0.001), or radiation dose (RR, 2.1; 95% CI, 1.2-3.1; P = 0.00193). Current smoking showed significantly higher risk for diffuse-type than intestinal-type tumors (P = 0.0372). Radiation risk was significant only for nonsmokers, all noncardia, and diffuse-type gastric cancers. CONCLUSIONS: A low CagA IgG titer is a useful biomarker to identify a high-risk group and it also provides a clue to understanding host-pathogen interaction. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/17548689/Low_positive_antibody_titer_against_Helicobacter_pylori_cytotoxin_associated_gene_A__CagA__may_predict_future_gastric_cancer_better_than_simple_seropositivity_against_H__pylori_CagA_or_against_H__pylori_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&amp;pmid=17548689 DB - PRIME DP - Unbound Medicine ER -