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Dietary iron and heme iron intake and risk of breast cancer: a prospective cohort study.
Cancer Epidemiol Biomarkers Prev. 2007 Jun; 16(6):1306-8.CE

Abstract

Recent studies suggest that elevated body iron levels may contribute to breast carcinogenesis; however, epidemiologic evidence is lacking. We used data from a large cohort study of Canadian women to assess breast cancer in association with total iron and heme iron intake. Among 49,654 women ages 40 to 59 followed for an average of 16.4 years, we identified 2,545 incident breast cancer cases. Data from a food frequency questionnaire administered at baseline were used to calculate total dietary iron and heme iron intake. Using Cox proportional hazards models, we found no association of iron or heme iron intake with risk of breast cancer overall, in women consuming 30+ g of alcohol per day, or in women who had ever used hormone replacement therapy. The present study offers no support for an association of iron or heme iron intake with breast cancer risk or for a modification by iron of the effect of alcohol or estrogen. However, further cohort studies with repeated measurement of iron intake are warranted.

Authors+Show Affiliations

Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA. gkabat@aecom.yu.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17548704

Citation

Kabat, Geoffrey C., et al. "Dietary Iron and Heme Iron Intake and Risk of Breast Cancer: a Prospective Cohort Study." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 16, no. 6, 2007, pp. 1306-8.
Kabat GC, Miller AB, Jain M, et al. Dietary iron and heme iron intake and risk of breast cancer: a prospective cohort study. Cancer Epidemiol Biomarkers Prev. 2007;16(6):1306-8.
Kabat, G. C., Miller, A. B., Jain, M., & Rohan, T. E. (2007). Dietary iron and heme iron intake and risk of breast cancer: a prospective cohort study. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 16(6), 1306-8.
Kabat GC, et al. Dietary Iron and Heme Iron Intake and Risk of Breast Cancer: a Prospective Cohort Study. Cancer Epidemiol Biomarkers Prev. 2007;16(6):1306-8. PubMed PMID: 17548704.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary iron and heme iron intake and risk of breast cancer: a prospective cohort study. AU - Kabat,Geoffrey C, AU - Miller,Anthony B, AU - Jain,Meera, AU - Rohan,Thomas E, PY - 2007/6/6/pubmed PY - 2007/10/4/medline PY - 2007/6/6/entrez SP - 1306 EP - 8 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol Biomarkers Prev VL - 16 IS - 6 N2 - Recent studies suggest that elevated body iron levels may contribute to breast carcinogenesis; however, epidemiologic evidence is lacking. We used data from a large cohort study of Canadian women to assess breast cancer in association with total iron and heme iron intake. Among 49,654 women ages 40 to 59 followed for an average of 16.4 years, we identified 2,545 incident breast cancer cases. Data from a food frequency questionnaire administered at baseline were used to calculate total dietary iron and heme iron intake. Using Cox proportional hazards models, we found no association of iron or heme iron intake with risk of breast cancer overall, in women consuming 30+ g of alcohol per day, or in women who had ever used hormone replacement therapy. The present study offers no support for an association of iron or heme iron intake with breast cancer risk or for a modification by iron of the effect of alcohol or estrogen. However, further cohort studies with repeated measurement of iron intake are warranted. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/17548704/Dietary_iron_and_heme_iron_intake_and_risk_of_breast_cancer:_a_prospective_cohort_study_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=17548704 DB - PRIME DP - Unbound Medicine ER -