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Physical activity and inactivity in relation to sex hormone, prolactin, and insulin-like growth factor concentrations in premenopausal women - exercise and premenopausal hormones.
Cancer Causes Control. 2007 Sep; 18(7):743-52.CC

Abstract

An association between physical activity and premenopausal breast cancer risk may be due, in part, to relationships with sex hormones or growth factors. Therefore, we assessed whether MET-h/week of total physical activity (moderate-to-vigorous intensity), walking, or vigorous physical activity, and h/week of standing or sitting were associated with plasma concentrations of several hormones. We examined levels of estrogens, androgens, progesterone, prolactin, sex hormone binding globulin (SHBG), insulin-like growth factor-1 (IGF-1), IGF binding protein-3, and growth hormone (GH) in 565 premenopausal women, ages 33-52 years, from the Nurses' Health Study II (NHSII). About 87% of women had both timed follicular and luteal samples; other women had one untimed sample. In general we observed few associations between sex hormone or IGF levels and measures of physical activity or inactivity. However, free testosterone was modestly inversely associated with total physical activity (p-trend = 0.02). Luteal estradiol, free estradiol, and estrone also were inversely associated with total physical activity (p-trend = 0.10, 0.04, 0.01, respectively); however, the trend was substantially attenuated when excluding women with anovulatory cycles or irregular cycles. These cross-sectional results suggest that physical activity and inactivity have limited associations with premenopausal sex hormone and growth factor levels, except possibly luteal estrogens.

Authors+Show Affiliations

Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Ave., 3rd Floor, Boston, MA 02115, USA. nhsst@channing.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

17549594

Citation

Tworoger, Shelley S., et al. "Physical Activity and Inactivity in Relation to Sex Hormone, Prolactin, and Insulin-like Growth Factor Concentrations in Premenopausal Women - Exercise and Premenopausal Hormones." Cancer Causes & Control : CCC, vol. 18, no. 7, 2007, pp. 743-52.
Tworoger SS, Missmer SA, Eliassen AH, et al. Physical activity and inactivity in relation to sex hormone, prolactin, and insulin-like growth factor concentrations in premenopausal women - exercise and premenopausal hormones. Cancer Causes Control. 2007;18(7):743-52.
Tworoger, S. S., Missmer, S. A., Eliassen, A. H., Barbieri, R. L., Dowsett, M., & Hankinson, S. E. (2007). Physical activity and inactivity in relation to sex hormone, prolactin, and insulin-like growth factor concentrations in premenopausal women - exercise and premenopausal hormones. Cancer Causes & Control : CCC, 18(7), 743-52.
Tworoger SS, et al. Physical Activity and Inactivity in Relation to Sex Hormone, Prolactin, and Insulin-like Growth Factor Concentrations in Premenopausal Women - Exercise and Premenopausal Hormones. Cancer Causes Control. 2007;18(7):743-52. PubMed PMID: 17549594.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Physical activity and inactivity in relation to sex hormone, prolactin, and insulin-like growth factor concentrations in premenopausal women - exercise and premenopausal hormones. AU - Tworoger,Shelley S, AU - Missmer,Stacey A, AU - Eliassen,A Heather, AU - Barbieri,Robert L, AU - Dowsett,Mitch, AU - Hankinson,Susan E, Y1 - 2007/06/05/ PY - 2006/09/20/received PY - 2007/04/23/accepted PY - 2007/6/6/pubmed PY - 2007/8/30/medline PY - 2007/6/6/entrez SP - 743 EP - 52 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 18 IS - 7 N2 - An association between physical activity and premenopausal breast cancer risk may be due, in part, to relationships with sex hormones or growth factors. Therefore, we assessed whether MET-h/week of total physical activity (moderate-to-vigorous intensity), walking, or vigorous physical activity, and h/week of standing or sitting were associated with plasma concentrations of several hormones. We examined levels of estrogens, androgens, progesterone, prolactin, sex hormone binding globulin (SHBG), insulin-like growth factor-1 (IGF-1), IGF binding protein-3, and growth hormone (GH) in 565 premenopausal women, ages 33-52 years, from the Nurses' Health Study II (NHSII). About 87% of women had both timed follicular and luteal samples; other women had one untimed sample. In general we observed few associations between sex hormone or IGF levels and measures of physical activity or inactivity. However, free testosterone was modestly inversely associated with total physical activity (p-trend = 0.02). Luteal estradiol, free estradiol, and estrone also were inversely associated with total physical activity (p-trend = 0.10, 0.04, 0.01, respectively); however, the trend was substantially attenuated when excluding women with anovulatory cycles or irregular cycles. These cross-sectional results suggest that physical activity and inactivity have limited associations with premenopausal sex hormone and growth factor levels, except possibly luteal estrogens. SN - 0957-5243 UR - https://www.unboundmedicine.com/medline/citation/17549594/Physical_activity_and_inactivity_in_relation_to_sex_hormone_prolactin_and_insulin_like_growth_factor_concentrations_in_premenopausal_women___exercise_and_premenopausal_hormones_ L2 - https://doi.org/10.1007/s10552-007-9017-5 DB - PRIME DP - Unbound Medicine ER -