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Screening for gestational diabetes at antenatal booking in a Malaysian university hospital: the role of risk factors and threshold value for the 50-g glucose challenge test.
Aust N Z J Obstet Gynaecol. 2007 Jun; 47(3):191-7.AN

Abstract

BACKGROUND

The best method of screening for gestational diabetes (GDM) remains unsettled. The 50-g glucose challenge test (GCT) is used in a two-stage screening process but its best threshold value can vary according to population.

AIMS

To evaluate the role of risk factors in conjunction with GCT and to determine an appropriate threshold for the one-hour venous plasma glucose with the GCT.

METHOD

In a prospective study, 1600 women at antenatal booking without a history of diabetes mellitus or GDM filled a form on risk factors before GCT. Women who had GCT >or= 7.2 mmol/L underwent the 75-g oral glucose tolerance test (OGTT). GDM was diagnosed according to WHO (1999) criteria.

RESULT

Thirty-five per cent had GCT >or= 7.2 mmol/L, 32.6% underwent OGTT and 34.5% of OGTT confirmed GDM. The GDM rate in our population was at least 11.4%. Examination of the receiver operator characteristic curve suggested that the best threshold value for the GCT in our population was >or= 7.6 mmol/L. Multivariable logistic regression demonstrated that only GCT >or= 7.6 mmol/L was an independent predictor for GDM (adjusted odds ratio 3.7: P < 0.001). After GCT, maternal age and anthropometry, OGTT during the third trimester, family history, obstetric history and glycosuria were not independent predictors of GDM.

CONCLUSIONS

Risk factors were not independent predictors of GDM in women with GCT >or= 7.2 mmol/L. GCT threshold value >or= 7.6 mmol is appropriate for the Malaysian population at high risk of GDM.

Authors+Show Affiliations

Department of Obstetrics and Gynaecology, University of Malaya, Lembah Pantai, Kuala Lumpur, Malaysia. pctan@um.edu.myNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

17550485

Citation

Tan, Peng Chiong, et al. "Screening for Gestational Diabetes at Antenatal Booking in a Malaysian University Hospital: the Role of Risk Factors and Threshold Value for the 50-g Glucose Challenge Test." The Australian & New Zealand Journal of Obstetrics & Gynaecology, vol. 47, no. 3, 2007, pp. 191-7.
Tan PC, Ling LP, Omar SZ. Screening for gestational diabetes at antenatal booking in a Malaysian university hospital: the role of risk factors and threshold value for the 50-g glucose challenge test. Aust N Z J Obstet Gynaecol. 2007;47(3):191-7.
Tan, P. C., Ling, L. P., & Omar, S. Z. (2007). Screening for gestational diabetes at antenatal booking in a Malaysian university hospital: the role of risk factors and threshold value for the 50-g glucose challenge test. The Australian & New Zealand Journal of Obstetrics & Gynaecology, 47(3), 191-7.
Tan PC, Ling LP, Omar SZ. Screening for Gestational Diabetes at Antenatal Booking in a Malaysian University Hospital: the Role of Risk Factors and Threshold Value for the 50-g Glucose Challenge Test. Aust N Z J Obstet Gynaecol. 2007;47(3):191-7. PubMed PMID: 17550485.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Screening for gestational diabetes at antenatal booking in a Malaysian university hospital: the role of risk factors and threshold value for the 50-g glucose challenge test. AU - Tan,Peng Chiong, AU - Ling,Liza Ping, AU - Omar,Siti Zawiah, PY - 2007/6/7/pubmed PY - 2007/9/20/medline PY - 2007/6/7/entrez SP - 191 EP - 7 JF - The Australian & New Zealand journal of obstetrics & gynaecology JO - Aust N Z J Obstet Gynaecol VL - 47 IS - 3 N2 - BACKGROUND: The best method of screening for gestational diabetes (GDM) remains unsettled. The 50-g glucose challenge test (GCT) is used in a two-stage screening process but its best threshold value can vary according to population. AIMS: To evaluate the role of risk factors in conjunction with GCT and to determine an appropriate threshold for the one-hour venous plasma glucose with the GCT. METHOD: In a prospective study, 1600 women at antenatal booking without a history of diabetes mellitus or GDM filled a form on risk factors before GCT. Women who had GCT >or= 7.2 mmol/L underwent the 75-g oral glucose tolerance test (OGTT). GDM was diagnosed according to WHO (1999) criteria. RESULT: Thirty-five per cent had GCT >or= 7.2 mmol/L, 32.6% underwent OGTT and 34.5% of OGTT confirmed GDM. The GDM rate in our population was at least 11.4%. Examination of the receiver operator characteristic curve suggested that the best threshold value for the GCT in our population was >or= 7.6 mmol/L. Multivariable logistic regression demonstrated that only GCT >or= 7.6 mmol/L was an independent predictor for GDM (adjusted odds ratio 3.7: P < 0.001). After GCT, maternal age and anthropometry, OGTT during the third trimester, family history, obstetric history and glycosuria were not independent predictors of GDM. CONCLUSIONS: Risk factors were not independent predictors of GDM in women with GCT >or= 7.2 mmol/L. GCT threshold value >or= 7.6 mmol is appropriate for the Malaysian population at high risk of GDM. SN - 0004-8666 UR - https://www.unboundmedicine.com/medline/citation/17550485/Screening_for_gestational_diabetes_at_antenatal_booking_in_a_Malaysian_university_hospital:_the_role_of_risk_factors_and_threshold_value_for_the_50_g_glucose_challenge_test_ L2 - https://doi.org/10.1111/j.1479-828X.2007.00717.x DB - PRIME DP - Unbound Medicine ER -