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A randomised control trial examining the effect of an antioxidant (Menevit) on pregnancy outcome during IVF-ICSI treatment.
Aust N Z J Obstet Gynaecol. 2007 Jun; 47(3):216-21.AN

Abstract

BACKGROUND

Evidence has accumulated supporting the role of reactive oxygen species (ROS) in the pathogenesis of sperm dysfunction among men with infertility. Damage to sperm DNA by ROS can lead to failure of conception, miscarriage or potentially even childhood cancer. The objective of this study was to examine the effect of male antioxidant treatment on embryo quality and pregnancy outcome during in vitro fertilisation-intracytoplasmic sperm injection (IVF-ICSI) treatment.

METHODS

Sixty couples with severe male factor infertility were enrolled in a prospective randomised double-blind placebo-controlled trial. Male participants were randomly assigned to take either one capsule per day of the Menevit antioxidant or an identical in appearance placebo for three months prior to their partner's IVF cycle. The primary outcome was cleavage stage embryo quality and the secondary outcomes were oocyte fertilisation rate, pregnancy rates and treatment side-effects. Approval by the local Human Research Ethics Committee was obtained prior to the commencement of this study.

RESULTS

The antioxidant group recorded a statistically significant improvement in viable pregnancy rate (38.5% of transferred embryos resulting in a viable fetus at 13 weeks gestation) compared to the control group (16% viable pregnancy). No significant changes in oocyte fertilisation rate or embryo quality were detected between the antioxidant and the placebo groups. Side-effects on the Menevit antioxidant were rare (8%) and mild in nature.

CONCLUSIONS

The Menevit antioxidant appears to be a useful ancillary treatment that significantly improves pregnancy rates in couples undergoing IVF-ICSI treatment for severe male factor infertility.

Authors+Show Affiliations

Repromed, Dulwich, SA 5065, Australia. kelton.tremellen@adelaide.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

17550489

Citation

Tremellen, Kelton, et al. "A Randomised Control Trial Examining the Effect of an Antioxidant (Menevit) On Pregnancy Outcome During IVF-ICSI Treatment." The Australian & New Zealand Journal of Obstetrics & Gynaecology, vol. 47, no. 3, 2007, pp. 216-21.
Tremellen K, Miari G, Froiland D, et al. A randomised control trial examining the effect of an antioxidant (Menevit) on pregnancy outcome during IVF-ICSI treatment. Aust N Z J Obstet Gynaecol. 2007;47(3):216-21.
Tremellen, K., Miari, G., Froiland, D., & Thompson, J. (2007). A randomised control trial examining the effect of an antioxidant (Menevit) on pregnancy outcome during IVF-ICSI treatment. The Australian & New Zealand Journal of Obstetrics & Gynaecology, 47(3), 216-21.
Tremellen K, et al. A Randomised Control Trial Examining the Effect of an Antioxidant (Menevit) On Pregnancy Outcome During IVF-ICSI Treatment. Aust N Z J Obstet Gynaecol. 2007;47(3):216-21. PubMed PMID: 17550489.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A randomised control trial examining the effect of an antioxidant (Menevit) on pregnancy outcome during IVF-ICSI treatment. AU - Tremellen,Kelton, AU - Miari,George, AU - Froiland,David, AU - Thompson,Jeremy, PY - 2007/6/7/pubmed PY - 2007/9/20/medline PY - 2007/6/7/entrez SP - 216 EP - 21 JF - The Australian & New Zealand journal of obstetrics & gynaecology JO - Aust N Z J Obstet Gynaecol VL - 47 IS - 3 N2 - BACKGROUND: Evidence has accumulated supporting the role of reactive oxygen species (ROS) in the pathogenesis of sperm dysfunction among men with infertility. Damage to sperm DNA by ROS can lead to failure of conception, miscarriage or potentially even childhood cancer. The objective of this study was to examine the effect of male antioxidant treatment on embryo quality and pregnancy outcome during in vitro fertilisation-intracytoplasmic sperm injection (IVF-ICSI) treatment. METHODS: Sixty couples with severe male factor infertility were enrolled in a prospective randomised double-blind placebo-controlled trial. Male participants were randomly assigned to take either one capsule per day of the Menevit antioxidant or an identical in appearance placebo for three months prior to their partner's IVF cycle. The primary outcome was cleavage stage embryo quality and the secondary outcomes were oocyte fertilisation rate, pregnancy rates and treatment side-effects. Approval by the local Human Research Ethics Committee was obtained prior to the commencement of this study. RESULTS: The antioxidant group recorded a statistically significant improvement in viable pregnancy rate (38.5% of transferred embryos resulting in a viable fetus at 13 weeks gestation) compared to the control group (16% viable pregnancy). No significant changes in oocyte fertilisation rate or embryo quality were detected between the antioxidant and the placebo groups. Side-effects on the Menevit antioxidant were rare (8%) and mild in nature. CONCLUSIONS: The Menevit antioxidant appears to be a useful ancillary treatment that significantly improves pregnancy rates in couples undergoing IVF-ICSI treatment for severe male factor infertility. SN - 0004-8666 UR - https://www.unboundmedicine.com/medline/citation/17550489/A_randomised_control_trial_examining_the_effect_of_an_antioxidant__Menevit__on_pregnancy_outcome_during_IVF_ICSI_treatment_ L2 - https://doi.org/10.1111/j.1479-828X.2007.00723.x DB - PRIME DP - Unbound Medicine ER -