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Synthesis and properties of star oligo/poly(trimethylene carbonate)s with cholic acid moieties as cores.
J Biomater Sci Polym Ed 2007; 18(5):519-30JB

Abstract

Star oligo/poly(trimethylene carbonate)s with cholic acid moieties as cores were synthesized by ring-opening polymerization of trimethylene carbonate (TMC) initiated by cholic acid with hydroxyl groups. The molecular weights of the star oligomers/polymers were controlled by adjusting the feed ratio of the initiator cholic acid to the monomer TMC. The star oligo/poly(trimethylene carbonate)s were characterized by Fourier transform infrared spectroscopy (FT-IR), (1)H nuclear magnetic resonance spectroscopy ((1)H-NMR) and combined size-exclusion chromatography and multiangle laser light scattering (SEC-MALLS) analysis. The water contact angles of the star oligo/poly(trimethylene carbonate)s were measured. Using 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay, the star oligo/poly(trimethylene carbonate) was proved to have a low cytotoxicity. A microsphere drug-delivery system based on a star polymer was fabricated and its in vitro drug release property was studied.

Authors+Show Affiliations

Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, P. R. China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17550656

Citation

Zou, Tao, et al. "Synthesis and Properties of Star Oligo/poly(trimethylene Carbonate)s With Cholic Acid Moieties as Cores." Journal of Biomaterials Science. Polymer Edition, vol. 18, no. 5, 2007, pp. 519-30.
Zou T, Li SL, Hu ZY, et al. Synthesis and properties of star oligo/poly(trimethylene carbonate)s with cholic acid moieties as cores. J Biomater Sci Polym Ed. 2007;18(5):519-30.
Zou, T., Li, S. L., Hu, Z. Y., Cheng, S. X., & Zhuo, R. X. (2007). Synthesis and properties of star oligo/poly(trimethylene carbonate)s with cholic acid moieties as cores. Journal of Biomaterials Science. Polymer Edition, 18(5), pp. 519-30.
Zou T, et al. Synthesis and Properties of Star Oligo/poly(trimethylene Carbonate)s With Cholic Acid Moieties as Cores. J Biomater Sci Polym Ed. 2007;18(5):519-30. PubMed PMID: 17550656.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synthesis and properties of star oligo/poly(trimethylene carbonate)s with cholic acid moieties as cores. AU - Zou,Tao, AU - Li,Song-Lin, AU - Hu,Zhao-Yu, AU - Cheng,Si-Xue, AU - Zhuo,Ren-Xi, PY - 2007/6/7/pubmed PY - 2007/9/6/medline PY - 2007/6/7/entrez SP - 519 EP - 30 JF - Journal of biomaterials science. Polymer edition JO - J Biomater Sci Polym Ed VL - 18 IS - 5 N2 - Star oligo/poly(trimethylene carbonate)s with cholic acid moieties as cores were synthesized by ring-opening polymerization of trimethylene carbonate (TMC) initiated by cholic acid with hydroxyl groups. The molecular weights of the star oligomers/polymers were controlled by adjusting the feed ratio of the initiator cholic acid to the monomer TMC. The star oligo/poly(trimethylene carbonate)s were characterized by Fourier transform infrared spectroscopy (FT-IR), (1)H nuclear magnetic resonance spectroscopy ((1)H-NMR) and combined size-exclusion chromatography and multiangle laser light scattering (SEC-MALLS) analysis. The water contact angles of the star oligo/poly(trimethylene carbonate)s were measured. Using 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay, the star oligo/poly(trimethylene carbonate) was proved to have a low cytotoxicity. A microsphere drug-delivery system based on a star polymer was fabricated and its in vitro drug release property was studied. SN - 0920-5063 UR - https://www.unboundmedicine.com/medline/citation/17550656/Synthesis_and_properties_of_star_oligo/poly_trimethylene_carbonate_s_with_cholic_acid_moieties_as_cores_ L2 - http://www.tandfonline.com/doi/full/10.1163/156856207780852497 DB - PRIME DP - Unbound Medicine ER -