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Vitamin D receptor polymorphism in nutritional rickets.
Pediatr Endocrinol Rev 2006; 3 Suppl 3:476-9PE

Abstract

Although the pathophysiology of rickets and especially the central role of Vitamin D in this disease has been clarified since the 1920s, it is not completely understood why rickets is still prevalant in sunny countries. Furthermore, as we understand more about rickets, it appears that rickets is a heterogeneous disorder caused by vitamin D and/or Ca deficiency. Serum 25 and 1,25 OH vitamin D levels show a wide range of variation among children with rickets and the response to treatment is also variable. These observations suggest that individual susceptibility may play a role in the development of rickets. Polymorphisms in the Vitamin D receptor (VDR) gene were postulated to be associated with bone mineral density. VDR gene polymorphism could be influential in the development of rickets in some children as well. However, data in this regard are still scarce.

Authors+Show Affiliations

Marmara University, Division of Pediatric Endocrinology, Istanbul, Turkey. abereket@e-kolay.net

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17551469

Citation

Bereket, Abdullah. "Vitamin D Receptor Polymorphism in Nutritional Rickets." Pediatric Endocrinology Reviews : PER, vol. 3 Suppl 3, 2006, pp. 476-9.
Bereket A. Vitamin D receptor polymorphism in nutritional rickets. Pediatr Endocrinol Rev. 2006;3 Suppl 3:476-9.
Bereket, A. (2006). Vitamin D receptor polymorphism in nutritional rickets. Pediatric Endocrinology Reviews : PER, 3 Suppl 3, pp. 476-9.
Bereket A. Vitamin D Receptor Polymorphism in Nutritional Rickets. Pediatr Endocrinol Rev. 2006;3 Suppl 3:476-9. PubMed PMID: 17551469.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D receptor polymorphism in nutritional rickets. A1 - Bereket,Abdullah, PY - 2008/1/30/pubmed PY - 2008/1/30/medline PY - 2008/1/30/entrez SP - 476 EP - 9 JF - Pediatric endocrinology reviews : PER JO - Pediatr Endocrinol Rev VL - 3 Suppl 3 N2 - Although the pathophysiology of rickets and especially the central role of Vitamin D in this disease has been clarified since the 1920s, it is not completely understood why rickets is still prevalant in sunny countries. Furthermore, as we understand more about rickets, it appears that rickets is a heterogeneous disorder caused by vitamin D and/or Ca deficiency. Serum 25 and 1,25 OH vitamin D levels show a wide range of variation among children with rickets and the response to treatment is also variable. These observations suggest that individual susceptibility may play a role in the development of rickets. Polymorphisms in the Vitamin D receptor (VDR) gene were postulated to be associated with bone mineral density. VDR gene polymorphism could be influential in the development of rickets in some children as well. However, data in this regard are still scarce. SN - 1565-4753 UR - https://www.unboundmedicine.com/medline/citation/17551469/Vitamin_D_receptor_polymorphism_in_nutritional_rickets_ L2 - http://www.diseaseinfosearch.org/result/6326 DB - PRIME DP - Unbound Medicine ER -