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Passive force enhancement in single myofibrils.
Pflugers Arch. 2007 Nov; 455(2):367-71.PA

Abstract

The purpose of this study was to gain further insight into passive force enhancement by testing whether passive force enhancement occurs in single myofibrils. Myofibrils (n = 6) isolated from rabbit psoas muscle were fixed at a sarcomere length of 2.4 microm, and then stretched passively and actively to a sarcomere length of 3.4 microm. Passive force after deactivation of the myofibrils was increased after active compared to passive stretching. Therefore, passive force enhancement, previously observed in muscle and fiber preparations, also occurs in single myofibrils. Passive force enhancement in myofibrils ranged from 86 to 145% of the steady-state force observed after passive stretch. Because titin is the main source of passive force in myofibrils, we propose that titin might be responsible for passive force enhancement observed in myofibrils. We propose that this might occur through an increase in stiffness when calcium concentration increases upon activation.

Authors+Show Affiliations

Human Performance Laboratory, University of Calgary, Calgary, Canada.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

17551750

Citation

Joumaa, V, et al. "Passive Force Enhancement in Single Myofibrils." Pflugers Archiv : European Journal of Physiology, vol. 455, no. 2, 2007, pp. 367-71.
Joumaa V, Rassier DE, Leonard TR, et al. Passive force enhancement in single myofibrils. Pflugers Arch. 2007;455(2):367-71.
Joumaa, V., Rassier, D. E., Leonard, T. R., & Herzog, W. (2007). Passive force enhancement in single myofibrils. Pflugers Archiv : European Journal of Physiology, 455(2), 367-71.
Joumaa V, et al. Passive Force Enhancement in Single Myofibrils. Pflugers Arch. 2007;455(2):367-71. PubMed PMID: 17551750.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Passive force enhancement in single myofibrils. AU - Joumaa,V, AU - Rassier,D E, AU - Leonard,T R, AU - Herzog,W, Y1 - 2007/06/06/ PY - 2007/04/30/received PY - 2007/05/02/accepted PY - 2007/6/7/pubmed PY - 2008/7/1/medline PY - 2007/6/7/entrez SP - 367 EP - 71 JF - Pflugers Archiv : European journal of physiology JO - Pflugers Arch VL - 455 IS - 2 N2 - The purpose of this study was to gain further insight into passive force enhancement by testing whether passive force enhancement occurs in single myofibrils. Myofibrils (n = 6) isolated from rabbit psoas muscle were fixed at a sarcomere length of 2.4 microm, and then stretched passively and actively to a sarcomere length of 3.4 microm. Passive force after deactivation of the myofibrils was increased after active compared to passive stretching. Therefore, passive force enhancement, previously observed in muscle and fiber preparations, also occurs in single myofibrils. Passive force enhancement in myofibrils ranged from 86 to 145% of the steady-state force observed after passive stretch. Because titin is the main source of passive force in myofibrils, we propose that titin might be responsible for passive force enhancement observed in myofibrils. We propose that this might occur through an increase in stiffness when calcium concentration increases upon activation. SN - 0031-6768 UR - https://www.unboundmedicine.com/medline/citation/17551750/Passive_force_enhancement_in_single_myofibrils_ L2 - https://dx.doi.org/10.1007/s00424-007-0287-2 DB - PRIME DP - Unbound Medicine ER -