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Evaluation of client-specific outcome measures and activity monitoring to measure pain relief in cats with osteoarthritis.
J Vet Intern Med 2007 May-Jun; 21(3):410-6JV

Abstract

BACKGROUND

There are no validated systems for measuring pain from osteoarthritis in cats.

HYPOTHESIS

Owner subjective assessments and an activity monitor (AM) can be used to detect pain in cats with osteoarthritis and to assess efficacy of treatments.

ANIMALS

Thirteen cats older than 10 years old, with owner-assessed decreases in activity, painful arthritic joints, and clinically normal blood work were included and evaluated for 3 weeks.

METHODS

A collar-mounted AM measured activity and a client-specific outcome measure (CSOM) questionnaire characterized the severity of impairment. Overall global quality of life was also evaluated for each treatment. In weeks 2 and 3, meloxicam (0.1 mg/kg, day 1; 0.05 mg/kg, days 2-5) or a placebo was administered in a blinded, randomized, cross-over manner to test the assessment systems.

RESULTS

The cats had a median of 4 arthritic appendicular joints. Activity counts for the week when cats (complete data on activity; n=9) were administered meloxicam were significantly higher than at baseline (P = .02) but not after placebo (P = .06). Baseline activity counts were not significantly different from placebo (P = .6). The CSOM data (n=13) showed that owners considered their cats to be more active on meloxicam compared with baseline (P = .001) and placebo (P < .004), and more active on placebo than at baseline (P < .01). Global quality of life improved significantly with meloxicam (P < .042).

CONCLUSIONS AND CLINICAL IMPORTANCE

Both an AM and a CSOM system can detect behavior associated with pain relief in cats that are arthritic. Objective activity data might allow subjective assessment systems to be validated for use in clinical studies.

Authors+Show Affiliations

Comparative Pain Research Laboratory, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA. Duncan_Lascelles@ncsu.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17552444

Citation

Lascelles, B Duncan X., et al. "Evaluation of Client-specific Outcome Measures and Activity Monitoring to Measure Pain Relief in Cats With Osteoarthritis." Journal of Veterinary Internal Medicine, vol. 21, no. 3, 2007, pp. 410-6.
Lascelles BD, Hansen BD, Roe S, et al. Evaluation of client-specific outcome measures and activity monitoring to measure pain relief in cats with osteoarthritis. J Vet Intern Med. 2007;21(3):410-6.
Lascelles, B. D., Hansen, B. D., Roe, S., DePuy, V., Thomson, A., Pierce, C. C., ... Rowinski, E. (2007). Evaluation of client-specific outcome measures and activity monitoring to measure pain relief in cats with osteoarthritis. Journal of Veterinary Internal Medicine, 21(3), pp. 410-6.
Lascelles BD, et al. Evaluation of Client-specific Outcome Measures and Activity Monitoring to Measure Pain Relief in Cats With Osteoarthritis. J Vet Intern Med. 2007;21(3):410-6. PubMed PMID: 17552444.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of client-specific outcome measures and activity monitoring to measure pain relief in cats with osteoarthritis. AU - Lascelles,B Duncan X, AU - Hansen,Bernie D, AU - Roe,Simon, AU - DePuy,Venita, AU - Thomson,Andrea, AU - Pierce,Courtney C, AU - Smith,Eric S, AU - Rowinski,Elizabeth, PY - 2007/6/8/pubmed PY - 2007/7/10/medline PY - 2007/6/8/entrez SP - 410 EP - 6 JF - Journal of veterinary internal medicine JO - J. Vet. Intern. Med. VL - 21 IS - 3 N2 - BACKGROUND: There are no validated systems for measuring pain from osteoarthritis in cats. HYPOTHESIS: Owner subjective assessments and an activity monitor (AM) can be used to detect pain in cats with osteoarthritis and to assess efficacy of treatments. ANIMALS: Thirteen cats older than 10 years old, with owner-assessed decreases in activity, painful arthritic joints, and clinically normal blood work were included and evaluated for 3 weeks. METHODS: A collar-mounted AM measured activity and a client-specific outcome measure (CSOM) questionnaire characterized the severity of impairment. Overall global quality of life was also evaluated for each treatment. In weeks 2 and 3, meloxicam (0.1 mg/kg, day 1; 0.05 mg/kg, days 2-5) or a placebo was administered in a blinded, randomized, cross-over manner to test the assessment systems. RESULTS: The cats had a median of 4 arthritic appendicular joints. Activity counts for the week when cats (complete data on activity; n=9) were administered meloxicam were significantly higher than at baseline (P = .02) but not after placebo (P = .06). Baseline activity counts were not significantly different from placebo (P = .6). The CSOM data (n=13) showed that owners considered their cats to be more active on meloxicam compared with baseline (P = .001) and placebo (P < .004), and more active on placebo than at baseline (P < .01). Global quality of life improved significantly with meloxicam (P < .042). CONCLUSIONS AND CLINICAL IMPORTANCE: Both an AM and a CSOM system can detect behavior associated with pain relief in cats that are arthritic. Objective activity data might allow subjective assessment systems to be validated for use in clinical studies. SN - 0891-6640 UR - https://www.unboundmedicine.com/medline/citation/17552444/Evaluation_of_client_specific_outcome_measures_and_activity_monitoring_to_measure_pain_relief_in_cats_with_osteoarthritis_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0891-6640&amp;date=2007&amp;volume=21&amp;issue=3&amp;spage=410 DB - PRIME DP - Unbound Medicine ER -