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Artificial reduction in transepidermal water loss improves skin barrier function.
Br J Dermatol. 2007 Jul; 157(1):82-6.BJ

Abstract

BACKGROUND

Artificial reduction of abnormal transepidermal water loss (TEWL) is considered to improve skin diseases associated with a defective barrier function. Treatment of the skin with moisturizers is also known to influence skin barrier function. Whether or not differences in occlusion between creams contribute to their effects on the skin barrier function is unknown.

OBJECTIVES

To investigate the long-term effects of a semipermeable membrane on the skin barrier function in normal skin. In addition, the occlusive properties of two creams were studied.

METHODS

The study was randomized, controlled and evaluator-blind using measurement of TEWL and skin susceptibility to sodium lauryl sulphate as indicators of skin barrier function.

RESULTS

Coating of the skin with a silicone membrane for 23 h per day for 3 weeks improved skin barrier function, whereas no significant changes were found after using the membrane for 8 h per day.

CONCLUSIONS

Differences between creams in terms of their effect on skin barrier function cannot be solely explained by their occlusive properties.

Authors+Show Affiliations

ACO HUD NORDIC AB, Research and Development, Box 622, SE-194 26 Upplands Väsby, Sweden.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

17553058

Citation

Buraczewska, I, et al. "Artificial Reduction in Transepidermal Water Loss Improves Skin Barrier Function." The British Journal of Dermatology, vol. 157, no. 1, 2007, pp. 82-6.
Buraczewska I, Broström U, Lodén M. Artificial reduction in transepidermal water loss improves skin barrier function. Br J Dermatol. 2007;157(1):82-6.
Buraczewska, I., Broström, U., & Lodén, M. (2007). Artificial reduction in transepidermal water loss improves skin barrier function. The British Journal of Dermatology, 157(1), 82-6.
Buraczewska I, Broström U, Lodén M. Artificial Reduction in Transepidermal Water Loss Improves Skin Barrier Function. Br J Dermatol. 2007;157(1):82-6. PubMed PMID: 17553058.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Artificial reduction in transepidermal water loss improves skin barrier function. AU - Buraczewska,I, AU - Broström,U, AU - Lodén,M, Y1 - 2007/06/06/ PY - 2007/6/8/pubmed PY - 2007/9/11/medline PY - 2007/6/8/entrez SP - 82 EP - 6 JF - The British journal of dermatology JO - Br J Dermatol VL - 157 IS - 1 N2 - BACKGROUND: Artificial reduction of abnormal transepidermal water loss (TEWL) is considered to improve skin diseases associated with a defective barrier function. Treatment of the skin with moisturizers is also known to influence skin barrier function. Whether or not differences in occlusion between creams contribute to their effects on the skin barrier function is unknown. OBJECTIVES: To investigate the long-term effects of a semipermeable membrane on the skin barrier function in normal skin. In addition, the occlusive properties of two creams were studied. METHODS: The study was randomized, controlled and evaluator-blind using measurement of TEWL and skin susceptibility to sodium lauryl sulphate as indicators of skin barrier function. RESULTS: Coating of the skin with a silicone membrane for 23 h per day for 3 weeks improved skin barrier function, whereas no significant changes were found after using the membrane for 8 h per day. CONCLUSIONS: Differences between creams in terms of their effect on skin barrier function cannot be solely explained by their occlusive properties. SN - 0007-0963 UR - https://www.unboundmedicine.com/medline/citation/17553058/Artificial_reduction_in_transepidermal_water_loss_improves_skin_barrier_function_ L2 - https://doi.org/10.1111/j.1365-2133.2007.07965.x DB - PRIME DP - Unbound Medicine ER -