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Association between body size and colorectal adenoma recurrence.
Clin Gastroenterol Hepatol. 2007 Aug; 5(8):982-90.CG

Abstract

BACKGROUND & AIMS

Obesity has been associated with increased risk for colorectal adenoma, although its role as a risk factor after polypectomy for recurrence is unclear. Therefore, we sought to evaluate the effect of anthropometric measures of obesity on adenoma after polypectomy.

METHODS

Subjects with baseline adenomas (n = 2465) and follow-up colonoscopy data were drawn from 2 randomized trials designed to prevent adenoma recurrence.

RESULTS

Over a mean follow-up period of 3.1 years presence of a body mass index (BMI) > or = 30 kg/m2 was associated with a nonsignificant 17% increase in the odds for any adenoma recurrence among all subjects (odds ratio [OR], 1.17; 95% confidence interval [CI], 0.92-1.48). This result was confined to men (OR, 1.36; 95% CI, 1.01-1.83) and not observed for women (OR, 0.90; 95% CI, 0.60-1.33). Results for waist circumference did not reach statistical significance, although trends were similar to those for BMI. Analyses of the effects of obesity on more clinically significant lesions demonstrated that high BMI was a slightly stronger risk factor for advanced adenoma recurrences in men (OR, 1.62; 95% CI, 1.04-2.53) when compared with non-advanced lesions (OR, 1.26; 95% CI, 0.91-1.75). In addition, we observed an association for obesity and odds of adenoma recurrence among participants reporting a family history of colorectal cancer (OR, 2.25; 95% CI, 1.32-3.84) but not for those without (OR, 1.00; 95% CI, 0.77 to 1.31; P(int) = P = .008).

CONCLUSIONS

Our results support obesity as a risk factor for subsequent short-interval (mean follow-up time 3.1 years) development of colorectal adenomas, particularly among men and persons with a family history of colorectal cancer. Furthermore, obesity in men appears to be strongly associated with the development of clinically advanced lesions.

Authors+Show Affiliations

Mel and Enid Zuckerman Arizona College of Public Health, University of Arizona, Tucson, Arizona 85724-5024, USA. jacobse@u.arizona.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17553754

Citation

Jacobs, Elizabeth T., et al. "Association Between Body Size and Colorectal Adenoma Recurrence." Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association, vol. 5, no. 8, 2007, pp. 982-90.
Jacobs ET, Martínez ME, Alberts DS, et al. Association between body size and colorectal adenoma recurrence. Clin Gastroenterol Hepatol. 2007;5(8):982-90.
Jacobs, E. T., Martínez, M. E., Alberts, D. S., Jiang, R., Lance, P., Lowe, K. A., & Thompson, P. A. (2007). Association between body size and colorectal adenoma recurrence. Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association, 5(8), 982-90.
Jacobs ET, et al. Association Between Body Size and Colorectal Adenoma Recurrence. Clin Gastroenterol Hepatol. 2007;5(8):982-90. PubMed PMID: 17553754.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between body size and colorectal adenoma recurrence. AU - Jacobs,Elizabeth T, AU - Martínez,María Elena, AU - Alberts,David S, AU - Jiang,Ruiyun, AU - Lance,Peter, AU - Lowe,Kimberly A, AU - Thompson,Patricia A, Y1 - 2007/06/05/ PY - 2007/6/8/pubmed PY - 2007/12/6/medline PY - 2007/6/8/entrez SP - 982 EP - 90 JF - Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association JO - Clin Gastroenterol Hepatol VL - 5 IS - 8 N2 - BACKGROUND & AIMS: Obesity has been associated with increased risk for colorectal adenoma, although its role as a risk factor after polypectomy for recurrence is unclear. Therefore, we sought to evaluate the effect of anthropometric measures of obesity on adenoma after polypectomy. METHODS: Subjects with baseline adenomas (n = 2465) and follow-up colonoscopy data were drawn from 2 randomized trials designed to prevent adenoma recurrence. RESULTS: Over a mean follow-up period of 3.1 years presence of a body mass index (BMI) > or = 30 kg/m2 was associated with a nonsignificant 17% increase in the odds for any adenoma recurrence among all subjects (odds ratio [OR], 1.17; 95% confidence interval [CI], 0.92-1.48). This result was confined to men (OR, 1.36; 95% CI, 1.01-1.83) and not observed for women (OR, 0.90; 95% CI, 0.60-1.33). Results for waist circumference did not reach statistical significance, although trends were similar to those for BMI. Analyses of the effects of obesity on more clinically significant lesions demonstrated that high BMI was a slightly stronger risk factor for advanced adenoma recurrences in men (OR, 1.62; 95% CI, 1.04-2.53) when compared with non-advanced lesions (OR, 1.26; 95% CI, 0.91-1.75). In addition, we observed an association for obesity and odds of adenoma recurrence among participants reporting a family history of colorectal cancer (OR, 2.25; 95% CI, 1.32-3.84) but not for those without (OR, 1.00; 95% CI, 0.77 to 1.31; P(int) = P = .008). CONCLUSIONS: Our results support obesity as a risk factor for subsequent short-interval (mean follow-up time 3.1 years) development of colorectal adenomas, particularly among men and persons with a family history of colorectal cancer. Furthermore, obesity in men appears to be strongly associated with the development of clinically advanced lesions. SN - 1542-7714 UR - https://www.unboundmedicine.com/medline/citation/17553754/Association_between_body_size_and_colorectal_adenoma_recurrence_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1542-3565(07)00330-8 DB - PRIME DP - Unbound Medicine ER -