Tags

Type your tag names separated by a space and hit enter

Effect of atorvastatin on energy expenditure and skeletal muscle oxidative metabolism at rest and during exercise.
Clin Pharmacol Ther. 2008 Feb; 83(2):243-50.CP

Abstract

Statins are associated with adverse effects in skeletal muscle. This study tested the hypothesis that atorvastatin would increase the respiratory exchange ratio (RER) at rest and during exercise. Twenty-eight healthy subjects (mean age 52 years) were enrolled in a double-blind, placebo-controlled, randomized study of the effects of atorvastatin (40 mg/day) on whole body energetics over 8 weeks. Ventilatory gas exchange measurements, at rest and during bicycle ergometry, were used to assess muscle oxidative metabolism. Thirteen subjects from each treatment arm completed the study. Eight weeks of atorvastatin lowered plasma low-density lipoprotein cholesterol concentration but had no effect on resting or submaximal energy expenditure, RER, or calculated fatty acid oxidation rates. Atorvastatin did not affect maximal exercise oxygen consumption or the anaerobic threshold. Eight weeks of atorvastatin therapy was not associated with alterations in substrate oxidation, or muscle oxidative function at rest, or during exercise in healthy adults.

Authors+Show Affiliations

The Colorado Prevention Center, University of Colorado Health Sciences Center, Denver, Colorado, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17554242

Citation

Chung, J, et al. "Effect of Atorvastatin On Energy Expenditure and Skeletal Muscle Oxidative Metabolism at Rest and During Exercise." Clinical Pharmacology and Therapeutics, vol. 83, no. 2, 2008, pp. 243-50.
Chung J, Brass EP, Ulrich RG, et al. Effect of atorvastatin on energy expenditure and skeletal muscle oxidative metabolism at rest and during exercise. Clin Pharmacol Ther. 2008;83(2):243-50.
Chung, J., Brass, E. P., Ulrich, R. G., & Hiatt, W. R. (2008). Effect of atorvastatin on energy expenditure and skeletal muscle oxidative metabolism at rest and during exercise. Clinical Pharmacology and Therapeutics, 83(2), 243-50.
Chung J, et al. Effect of Atorvastatin On Energy Expenditure and Skeletal Muscle Oxidative Metabolism at Rest and During Exercise. Clin Pharmacol Ther. 2008;83(2):243-50. PubMed PMID: 17554242.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of atorvastatin on energy expenditure and skeletal muscle oxidative metabolism at rest and during exercise. AU - Chung,J, AU - Brass,E P, AU - Ulrich,R G, AU - Hiatt,W R, Y1 - 2007/06/06/ PY - 2007/6/8/pubmed PY - 2008/2/22/medline PY - 2007/6/8/entrez SP - 243 EP - 50 JF - Clinical pharmacology and therapeutics JO - Clin Pharmacol Ther VL - 83 IS - 2 N2 - Statins are associated with adverse effects in skeletal muscle. This study tested the hypothesis that atorvastatin would increase the respiratory exchange ratio (RER) at rest and during exercise. Twenty-eight healthy subjects (mean age 52 years) were enrolled in a double-blind, placebo-controlled, randomized study of the effects of atorvastatin (40 mg/day) on whole body energetics over 8 weeks. Ventilatory gas exchange measurements, at rest and during bicycle ergometry, were used to assess muscle oxidative metabolism. Thirteen subjects from each treatment arm completed the study. Eight weeks of atorvastatin lowered plasma low-density lipoprotein cholesterol concentration but had no effect on resting or submaximal energy expenditure, RER, or calculated fatty acid oxidation rates. Atorvastatin did not affect maximal exercise oxygen consumption or the anaerobic threshold. Eight weeks of atorvastatin therapy was not associated with alterations in substrate oxidation, or muscle oxidative function at rest, or during exercise in healthy adults. SN - 1532-6535 UR - https://www.unboundmedicine.com/medline/citation/17554242/Effect_of_atorvastatin_on_energy_expenditure_and_skeletal_muscle_oxidative_metabolism_at_rest_and_during_exercise_ L2 - https://doi.org/10.1038/sj.clpt.6100264 DB - PRIME DP - Unbound Medicine ER -