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Environmental risk factors in the development of adenocarcinoma of the oesophagus or gastric cardia: a cross-sectional study in a Dutch cohort.

Abstract

BACKGROUND

Risk factors for adenocarcinoma of the oesophagus (OAC) and gastric cardia (GCA) are not yet established.

AIM

To compare environmental risk factors between patients with OAC and GCA.

METHODS

One-hundred and twenty-six patients with OAC, 43 with GCA and 57 with squamous cell carcinoma filled out a questionnaire with information on demographic and lifestyle characteristics, physical activity levels, family history, gastro-oesophageal reflux disease symptoms and medication use.

RESULTS

OAC and GCA patients were similar with regard to male predominance and age, alcohol intake and smoking, use of fruits and vegetables, body posture and occupational activities (P > 0.05). GCA patients less often had heartburn compared with OAC patients [odds ratio (OR) 0.5, 95% confidence interval (CI) 0.2-0.96] and had these symptoms less frequently and for a shorter period (OR 0.3, CI 0.1-1.0 and OR 0.1, CI 0.03-0.6, respectively). Former and current aspirin use was lower among GCA patients than OAC patients (OR 0.2, CI 0.05-0.7 and OR 0.4, CI 0.1-0.9, respectively), whereas no difference in non-steroidal anti-inflammatory drug use was detected.

CONCLUSION

Although OAC and GCA share several environmental risk factors, OAC is more frequently associated with a history of gastro-oesophageal reflux disease, suggesting a more important role for gastro-oesophageal reflux in OAC compared with GCA.

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  • Authors+Show Affiliations

    ,

    Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. p.dejonge@erasmusmc.nl

    , , , , ,

    Source

    MeSH

    Adenocarcinoma
    Aged
    Alcohol Drinking
    Body Mass Index
    Cross-Sectional Studies
    Diet
    Environment
    Esophageal Neoplasms
    Exercise
    Female
    Gastroesophageal Reflux
    Humans
    Life Style
    Male
    Middle Aged
    Risk Factors
    Smoking
    Stomach Neoplasms

    Pub Type(s)

    Comparative Study
    Journal Article

    Language

    eng

    PubMed ID

    17555419

    Citation

    DE Jonge, P J F., et al. "Environmental Risk Factors in the Development of Adenocarcinoma of the Oesophagus or Gastric Cardia: a Cross-sectional Study in a Dutch Cohort." Alimentary Pharmacology & Therapeutics, vol. 26, no. 1, 2007, pp. 31-9.
    DE Jonge PJ, Wolters LM, Steyerberg EW, et al. Environmental risk factors in the development of adenocarcinoma of the oesophagus or gastric cardia: a cross-sectional study in a Dutch cohort. Aliment Pharmacol Ther. 2007;26(1):31-9.
    DE Jonge, P. J., Wolters, L. M., Steyerberg, E. W., VAN Dekken, H., Kusters, J. G., Kuipers, E. J., & Siersema, P. D. (2007). Environmental risk factors in the development of adenocarcinoma of the oesophagus or gastric cardia: a cross-sectional study in a Dutch cohort. Alimentary Pharmacology & Therapeutics, 26(1), pp. 31-9.
    DE Jonge PJ, et al. Environmental Risk Factors in the Development of Adenocarcinoma of the Oesophagus or Gastric Cardia: a Cross-sectional Study in a Dutch Cohort. Aliment Pharmacol Ther. 2007 Jul 1;26(1):31-9. PubMed PMID: 17555419.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Environmental risk factors in the development of adenocarcinoma of the oesophagus or gastric cardia: a cross-sectional study in a Dutch cohort. AU - DE Jonge,P J F, AU - Wolters,L M M, AU - Steyerberg,E W, AU - VAN Dekken,H, AU - Kusters,J G, AU - Kuipers,E J, AU - Siersema,P D, PY - 2007/6/9/pubmed PY - 2007/9/27/medline PY - 2007/6/9/entrez SP - 31 EP - 9 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 26 IS - 1 N2 - BACKGROUND: Risk factors for adenocarcinoma of the oesophagus (OAC) and gastric cardia (GCA) are not yet established. AIM: To compare environmental risk factors between patients with OAC and GCA. METHODS: One-hundred and twenty-six patients with OAC, 43 with GCA and 57 with squamous cell carcinoma filled out a questionnaire with information on demographic and lifestyle characteristics, physical activity levels, family history, gastro-oesophageal reflux disease symptoms and medication use. RESULTS: OAC and GCA patients were similar with regard to male predominance and age, alcohol intake and smoking, use of fruits and vegetables, body posture and occupational activities (P > 0.05). GCA patients less often had heartburn compared with OAC patients [odds ratio (OR) 0.5, 95% confidence interval (CI) 0.2-0.96] and had these symptoms less frequently and for a shorter period (OR 0.3, CI 0.1-1.0 and OR 0.1, CI 0.03-0.6, respectively). Former and current aspirin use was lower among GCA patients than OAC patients (OR 0.2, CI 0.05-0.7 and OR 0.4, CI 0.1-0.9, respectively), whereas no difference in non-steroidal anti-inflammatory drug use was detected. CONCLUSION: Although OAC and GCA share several environmental risk factors, OAC is more frequently associated with a history of gastro-oesophageal reflux disease, suggesting a more important role for gastro-oesophageal reflux in OAC compared with GCA. SN - 0269-2813 UR - https://www.unboundmedicine.com/medline/citation/17555419/Environmental_risk_factors_in_the_development_of_adenocarcinoma_of_the_oesophagus_or_gastric_cardia:_a_cross_sectional_study_in_a_Dutch_cohort_ L2 - https://doi.org/10.1111/j.1365-2036.2007.03344.x DB - PRIME DP - Unbound Medicine ER -