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Effects of D-cycloserine on extinction: consequences of prior exposure to imipramine.
Biol Psychiatry. 2007 Nov 15; 62(10):1195-7.BP

Abstract

BACKGROUND

D-cycloserine (DCS), a partial N-methyl-D-aspartate (NMDA) agonist, facilitates the extinction of conditioned fear in animals and promotes the efficacy of exposure-based therapies in humans. The current study examined whether pre-exposure to the antidepressant imipramine affects the enhancement of extinction by DCS.

METHODS

Twenty-nine rats were pre-exposed to saline, DCS, or imipramine for 14 days. The next day they were given five noise-shock pairings. The day after training, rats received six extinction trials and were then injected with DCS. At test the following day, freezing elicited by the noise was measured.

RESULTS

Rats pre-exposed to either DCS or imipramine exhibited more freezing at test than rats pre-exposed to saline.

CONCLUSIONS

Chronic exposure to either DCS or imipramine prevents the facilitating effect of DCS on extinction. This result suggests that DCS may not effectively enhance loss of fear in patients who are also being treated with antidepressants.

Authors+Show Affiliations

School of Psychology, University of New South Wales, Sydney, Australia.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17555721

Citation

Werner-Seidler, Aliza, and Rick Richardson. "Effects of D-cycloserine On Extinction: Consequences of Prior Exposure to Imipramine." Biological Psychiatry, vol. 62, no. 10, 2007, pp. 1195-7.
Werner-Seidler A, Richardson R. Effects of D-cycloserine on extinction: consequences of prior exposure to imipramine. Biol Psychiatry. 2007;62(10):1195-7.
Werner-Seidler, A., & Richardson, R. (2007). Effects of D-cycloserine on extinction: consequences of prior exposure to imipramine. Biological Psychiatry, 62(10), 1195-7.
Werner-Seidler A, Richardson R. Effects of D-cycloserine On Extinction: Consequences of Prior Exposure to Imipramine. Biol Psychiatry. 2007 Nov 15;62(10):1195-7. PubMed PMID: 17555721.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of D-cycloserine on extinction: consequences of prior exposure to imipramine. AU - Werner-Seidler,Aliza, AU - Richardson,Rick, Y1 - 2007/06/06/ PY - 2007/02/20/received PY - 2007/03/22/revised PY - 2007/04/10/accepted PY - 2007/6/9/pubmed PY - 2008/2/2/medline PY - 2007/6/9/entrez SP - 1195 EP - 7 JF - Biological psychiatry JO - Biol Psychiatry VL - 62 IS - 10 N2 - BACKGROUND: D-cycloserine (DCS), a partial N-methyl-D-aspartate (NMDA) agonist, facilitates the extinction of conditioned fear in animals and promotes the efficacy of exposure-based therapies in humans. The current study examined whether pre-exposure to the antidepressant imipramine affects the enhancement of extinction by DCS. METHODS: Twenty-nine rats were pre-exposed to saline, DCS, or imipramine for 14 days. The next day they were given five noise-shock pairings. The day after training, rats received six extinction trials and were then injected with DCS. At test the following day, freezing elicited by the noise was measured. RESULTS: Rats pre-exposed to either DCS or imipramine exhibited more freezing at test than rats pre-exposed to saline. CONCLUSIONS: Chronic exposure to either DCS or imipramine prevents the facilitating effect of DCS on extinction. This result suggests that DCS may not effectively enhance loss of fear in patients who are also being treated with antidepressants. SN - 0006-3223 UR - https://www.unboundmedicine.com/medline/citation/17555721/Effects_of_D_cycloserine_on_extinction:_consequences_of_prior_exposure_to_imipramine_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-3223(07)00358-7 DB - PRIME DP - Unbound Medicine ER -