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Evaluation of HbA1c on the Roche COBAS Integra 800 closed tube system.
Clin Biochem. 2007 Jul; 40(11):822-7.CB

Abstract

OBJECTIVES

Evaluate a new whole blood (WB) HbA1c immunoassay and system with closed tube sampling (CTS) capability.

DESIGN AND METHODS

Compare the Tina-quant Haemoglobin A1c Gen.2 (A1C-2) application on the COBAS INTEGRA 800 (I800) and new I800 dedicated system with CTS capability to current Integra applications and a HbA1c method accurate with common haemoglobin (Hb) variants.

RESULTS

CVs were < or =1.7%. Mean bias against National Glycohaemoglobin Standardization Program (NGSP) samples was 0.3 HbA1c %. Compared to the Hitachi Tina-quant(R) [a] HbA1c II (HbA1c II) assay (accurate with common Hb variants), mean bias was 0.04% and 0.21% HbA1c at 6% and 9%, respectively, with Hb AS variants; and -0.01% and 0.26% HbA1c at 6% and 9%, respectively, with Hb AC variants.

CONCLUSIONS

The Integra A1C-2 application is precise, accurate against NGSP-assigned samples and the Hb variants tested; and, the I800 dedicated system with CTS capability offers increased throughput and reduced sample handling.

Authors+Show Affiliations

Laboratory Corporation of America, Elon, NC 27244, USA. fleminj@labcorp.com

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

17555737

Citation

Fleming, James K.. "Evaluation of HbA1c On the Roche COBAS Integra 800 Closed Tube System." Clinical Biochemistry, vol. 40, no. 11, 2007, pp. 822-7.
Fleming JK. Evaluation of HbA1c on the Roche COBAS Integra 800 closed tube system. Clin Biochem. 2007;40(11):822-7.
Fleming, J. K. (2007). Evaluation of HbA1c on the Roche COBAS Integra 800 closed tube system. Clinical Biochemistry, 40(11), 822-7.
Fleming JK. Evaluation of HbA1c On the Roche COBAS Integra 800 Closed Tube System. Clin Biochem. 2007;40(11):822-7. PubMed PMID: 17555737.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of HbA1c on the Roche COBAS Integra 800 closed tube system. A1 - Fleming,James K, Y1 - 2007/04/04/ PY - 2007/01/15/received PY - 2007/03/15/revised PY - 2007/03/18/accepted PY - 2007/6/9/pubmed PY - 2007/8/19/medline PY - 2007/6/9/entrez SP - 822 EP - 7 JF - Clinical biochemistry JO - Clin Biochem VL - 40 IS - 11 N2 - OBJECTIVES: Evaluate a new whole blood (WB) HbA1c immunoassay and system with closed tube sampling (CTS) capability. DESIGN AND METHODS: Compare the Tina-quant Haemoglobin A1c Gen.2 (A1C-2) application on the COBAS INTEGRA 800 (I800) and new I800 dedicated system with CTS capability to current Integra applications and a HbA1c method accurate with common haemoglobin (Hb) variants. RESULTS: CVs were < or =1.7%. Mean bias against National Glycohaemoglobin Standardization Program (NGSP) samples was 0.3 HbA1c %. Compared to the Hitachi Tina-quant(R) [a] HbA1c II (HbA1c II) assay (accurate with common Hb variants), mean bias was 0.04% and 0.21% HbA1c at 6% and 9%, respectively, with Hb AS variants; and -0.01% and 0.26% HbA1c at 6% and 9%, respectively, with Hb AC variants. CONCLUSIONS: The Integra A1C-2 application is precise, accurate against NGSP-assigned samples and the Hb variants tested; and, the I800 dedicated system with CTS capability offers increased throughput and reduced sample handling. SN - 0009-9120 UR - https://www.unboundmedicine.com/medline/citation/17555737/Evaluation_of_HbA1c_on_the_Roche_COBAS_Integra_800_closed_tube_system_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-9120(07)00135-X DB - PRIME DP - Unbound Medicine ER -