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Pre-emptive antinociceptive effects of a synthetic cannabinoid in a model of neuropathic pain.
Eur J Pharmacol 2007; 568(1-3):173-6EJ

Abstract

The antinociceptive effects of WIN55,212-2, a synthetic cannabinoid, were evaluated in the model of partial sciatic nerve ligation after daily subcutaneous administration of 0.1 mg/kg a week before and two weeks after surgery. Mechanical allodynia and thermal hyperalgesia were evaluated in 46 rats allocated to receive: (1) Vehicle (before surgery)-Vehicle (after surgery); (2) Vehicle-WIN55,212-2; (3) WIN55,212-2-Vehicle; (4) WIN55,212-2-WIN55,212-2; (5) AM251+vehicle; (6) AM251+WIN55,212-2; (7) AM630+vehicle; (8) AM630+WIN55,212-2; (9) Sham receiving vehicle; and (10) Sham receiving WIN55,212-2. The decreased in mechanical allodynia and thermal hyperalgesia by WIN55,212-2 was significantly greater when it was administered during one week before surgery. In conclusion, pre-emptive use of cannabinoids produced greater antinociceptive effects in a model of neuropathic pain and this effect is mediated by cannabinoid CB(1) and CB(2) receptors.

Authors+Show Affiliations

Department of Pharmacology, Faculty of Medicine, Université de Montréal-CHUM, 3840 rue St-Urbain, Montréal, Québec, Canada H2W 1T8.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17555742

Citation

Guindon, Josée, et al. "Pre-emptive Antinociceptive Effects of a Synthetic Cannabinoid in a Model of Neuropathic Pain." European Journal of Pharmacology, vol. 568, no. 1-3, 2007, pp. 173-6.
Guindon J, Desroches J, Dani M, et al. Pre-emptive antinociceptive effects of a synthetic cannabinoid in a model of neuropathic pain. Eur J Pharmacol. 2007;568(1-3):173-6.
Guindon, J., Desroches, J., Dani, M., & Beaulieu, P. (2007). Pre-emptive antinociceptive effects of a synthetic cannabinoid in a model of neuropathic pain. European Journal of Pharmacology, 568(1-3), pp. 173-6.
Guindon J, et al. Pre-emptive Antinociceptive Effects of a Synthetic Cannabinoid in a Model of Neuropathic Pain. Eur J Pharmacol. 2007 Jul 30;568(1-3):173-6. PubMed PMID: 17555742.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pre-emptive antinociceptive effects of a synthetic cannabinoid in a model of neuropathic pain. AU - Guindon,Josée, AU - Desroches,Julie, AU - Dani,Mélina, AU - Beaulieu,Pierre, Y1 - 2007/05/22/ PY - 2007/03/05/received PY - 2007/04/21/revised PY - 2007/04/24/accepted PY - 2007/6/9/pubmed PY - 2007/10/20/medline PY - 2007/6/9/entrez SP - 173 EP - 6 JF - European journal of pharmacology JO - Eur. J. Pharmacol. VL - 568 IS - 1-3 N2 - The antinociceptive effects of WIN55,212-2, a synthetic cannabinoid, were evaluated in the model of partial sciatic nerve ligation after daily subcutaneous administration of 0.1 mg/kg a week before and two weeks after surgery. Mechanical allodynia and thermal hyperalgesia were evaluated in 46 rats allocated to receive: (1) Vehicle (before surgery)-Vehicle (after surgery); (2) Vehicle-WIN55,212-2; (3) WIN55,212-2-Vehicle; (4) WIN55,212-2-WIN55,212-2; (5) AM251+vehicle; (6) AM251+WIN55,212-2; (7) AM630+vehicle; (8) AM630+WIN55,212-2; (9) Sham receiving vehicle; and (10) Sham receiving WIN55,212-2. The decreased in mechanical allodynia and thermal hyperalgesia by WIN55,212-2 was significantly greater when it was administered during one week before surgery. In conclusion, pre-emptive use of cannabinoids produced greater antinociceptive effects in a model of neuropathic pain and this effect is mediated by cannabinoid CB(1) and CB(2) receptors. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/17555742/Pre_emptive_antinociceptive_effects_of_a_synthetic_cannabinoid_in_a_model_of_neuropathic_pain_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(07)00542-0 DB - PRIME DP - Unbound Medicine ER -