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Frailty is associated with incident Alzheimer's disease and cognitive decline in the elderly.
Psychosom Med. 2007 Jun; 69(5):483-9.PM

Abstract

OBJECTIVE

To assess the association between frailty and incident Alzheimer's disease (AD) and cognitive decline. Frailty is common in older persons and associated with adverse health outcomes.

METHODS

Study subjects included 823 older persons without dementia who participated in the Rush Memory and Aging Project, a longitudinal study of aging, and underwent annual assessments of frailty, cognition, and diagnostic evaluation for AD.

RESULTS

During a 3-year follow-up, 89 of 823 participants developed AD. In a proportional hazards model, both baseline level of frailty and annual rate of change in frailty were associated with an increased risk of incident AD. Each additional one tenth of a unit increase on the frailty scale at baseline was associated with >9% increased risk of AD (hazard ratio: 2.44; 95% confidence interval (CI): 1.49, 3.37); each one tenth of a unit increase in annual rate of change in frailty was associated with a 12% increased risk of AD (hazard ratio: 3.30; 95% CI: 1.52, 7.13). These results were unchanged in analyses controlling for vascular risk factors and vascular diseases. Results were similar with a categorical measure of frailty instead of a continuous measure. Further, linear mixed-effects models showed that the level of and rate of change in frailty were also associated with the rate of cognitive decline.

CONCLUSION

Increasing frailty is associated with incident AD and the rate of cognitive decline in older persons. These findings suggest that frailty and AD may share similar etiologies.

Authors+Show Affiliations

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA. Aron_S_Buchman@rush.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17556640

Citation

Buchman, Aron S., et al. "Frailty Is Associated With Incident Alzheimer's Disease and Cognitive Decline in the Elderly." Psychosomatic Medicine, vol. 69, no. 5, 2007, pp. 483-9.
Buchman AS, Boyle PA, Wilson RS, et al. Frailty is associated with incident Alzheimer's disease and cognitive decline in the elderly. Psychosom Med. 2007;69(5):483-9.
Buchman, A. S., Boyle, P. A., Wilson, R. S., Tang, Y., & Bennett, D. A. (2007). Frailty is associated with incident Alzheimer's disease and cognitive decline in the elderly. Psychosomatic Medicine, 69(5), 483-9.
Buchman AS, et al. Frailty Is Associated With Incident Alzheimer's Disease and Cognitive Decline in the Elderly. Psychosom Med. 2007;69(5):483-9. PubMed PMID: 17556640.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Frailty is associated with incident Alzheimer's disease and cognitive decline in the elderly. AU - Buchman,Aron S, AU - Boyle,Patricia A, AU - Wilson,Robert S, AU - Tang,Yuxiao, AU - Bennett,David A, Y1 - 2007/06/07/ PY - 2007/6/9/pubmed PY - 2007/8/11/medline PY - 2007/6/9/entrez SP - 483 EP - 9 JF - Psychosomatic medicine JO - Psychosom Med VL - 69 IS - 5 N2 - OBJECTIVE: To assess the association between frailty and incident Alzheimer's disease (AD) and cognitive decline. Frailty is common in older persons and associated with adverse health outcomes. METHODS: Study subjects included 823 older persons without dementia who participated in the Rush Memory and Aging Project, a longitudinal study of aging, and underwent annual assessments of frailty, cognition, and diagnostic evaluation for AD. RESULTS: During a 3-year follow-up, 89 of 823 participants developed AD. In a proportional hazards model, both baseline level of frailty and annual rate of change in frailty were associated with an increased risk of incident AD. Each additional one tenth of a unit increase on the frailty scale at baseline was associated with >9% increased risk of AD (hazard ratio: 2.44; 95% confidence interval (CI): 1.49, 3.37); each one tenth of a unit increase in annual rate of change in frailty was associated with a 12% increased risk of AD (hazard ratio: 3.30; 95% CI: 1.52, 7.13). These results were unchanged in analyses controlling for vascular risk factors and vascular diseases. Results were similar with a categorical measure of frailty instead of a continuous measure. Further, linear mixed-effects models showed that the level of and rate of change in frailty were also associated with the rate of cognitive decline. CONCLUSION: Increasing frailty is associated with incident AD and the rate of cognitive decline in older persons. These findings suggest that frailty and AD may share similar etiologies. SN - 1534-7796 UR - https://www.unboundmedicine.com/medline/citation/17556640/Frailty_is_associated_with_incident_Alzheimer's_disease_and_cognitive_decline_in_the_elderly_ L2 - http://dx.doi.org/10.1097/psy.0b013e318068de1d DB - PRIME DP - Unbound Medicine ER -