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Increased plasma concentrations of lipoprotein(a) during a low-fat, high-carbohydrate diet are associated with increased plasma concentrations of apolipoprotein C-III bound to apolipoprotein B-containing lipoproteins.
Am J Clin Nutr. 2007 Jun; 85(6):1527-32.AJ

Abstract

BACKGROUND

Low-fat, high-carbohydrate (LFHC) diets have been shown to increase plasma concentrations of lipoprotein(a) [Lp(a)] and of triacylglycerol- rich lipoproteins (TRLs).

OBJECTIVE

We tested whether increases in plasma Lp(a) induced by an LFHC diet are related to changes in TRLs.

DESIGN

Healthy men (study 1; n = 140) consumed for 4 wk each a high-fat, low-carbohydrate diet (HFLC; 40% fat, 45% carbohydrate) and an LFHC diet (20% fat, 65% carbohydrate). Plasma lipids; lipoproteins; apolipoprotein (apo) B, A-I, and C-III; and Lp(a) were measured at the end of each diet. In a second group of men following a similar dietary protocol (study 2; n = 33), we isolated apo(a)-containing particles by immunoaffinity chromatography and determined the concentrations of apo C-III in ultracentrifugally isolated subfractions of apo B-containing lipoproteins.

RESULTS

In study 1, plasma concentrations of Lp(a) (P < 0.001), triacylglycerol (P < 0.001), apo B (P < 0.005), apo C-III (P < 0.005), and apo C-III in apo B-containing lipoproteins (non-HDL apo C-III) (P < 0.001) were significantly higher with the LFHC diet than with the HFLC diet. Stepwise multiple linear regression analysis showed that the association of changes in Lp(a) with changes in non-HDL apo C-III was independent of changes in body mass index, apo B, LDL cholesterol, and HDL cholesterol. Plasma lipid and lipoprotein changes were similar in study 2, and we found that both total apo C-III and the apo C-III content of apo(a)-containing particles were increased in a TRL fraction consisting predominantly of large VLDL particles [TRL-apo(a)].

CONCLUSIONS

The increase in plasma Lp(a) with an LFHC diet is significantly associated with an increase in non-HDL apo C-III. Enrichment of TRL-apo(a) with apo C-III may contribute to this dietary effect on Lp(a) concentrations.

Links

Publisher Full Text

Authors+Show Affiliations

Shin MJ
Children's Hospital Oakland Research Institute, Oakland, CA 94609, USA.
Blanche PJ
No affiliation info available
Rawlings RS
No affiliation info available
Fernstrom HS
No affiliation info available
Krauss RM
No affiliation info available

MeSH

AdultApolipoprotein C-IIIApolipoproteins BDiet, Fat-RestrictedDietary CarbohydratesHumansLipoprotein(a)LipoproteinsMaleTriglycerides

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17556688

Citation

Shin, Min-Jeong, et al. "Increased Plasma Concentrations of Lipoprotein(a) During a Low-fat, High-carbohydrate Diet Are Associated With Increased Plasma Concentrations of Apolipoprotein C-III Bound to Apolipoprotein B-containing Lipoproteins." The American Journal of Clinical Nutrition, vol. 85, no. 6, 2007, pp. 1527-32.
Shin MJ, Blanche PJ, Rawlings RS, et al. Increased plasma concentrations of lipoprotein(a) during a low-fat, high-carbohydrate diet are associated with increased plasma concentrations of apolipoprotein C-III bound to apolipoprotein B-containing lipoproteins. Am J Clin Nutr. 2007;85(6):1527-32.
Shin, M. J., Blanche, P. J., Rawlings, R. S., Fernstrom, H. S., & Krauss, R. M. (2007). Increased plasma concentrations of lipoprotein(a) during a low-fat, high-carbohydrate diet are associated with increased plasma concentrations of apolipoprotein C-III bound to apolipoprotein B-containing lipoproteins. The American Journal of Clinical Nutrition, 85(6), 1527-32.
Shin MJ, et al. Increased Plasma Concentrations of Lipoprotein(a) During a Low-fat, High-carbohydrate Diet Are Associated With Increased Plasma Concentrations of Apolipoprotein C-III Bound to Apolipoprotein B-containing Lipoproteins. Am J Clin Nutr. 2007;85(6):1527-32. PubMed PMID: 17556688.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased plasma concentrations of lipoprotein(a) during a low-fat, high-carbohydrate diet are associated with increased plasma concentrations of apolipoprotein C-III bound to apolipoprotein B-containing lipoproteins. AU - Shin,Min-Jeong, AU - Blanche,Patricia J, AU - Rawlings,Robin S, AU - Fernstrom,Harriett S, AU - Krauss,Ronald M, PY - 2007/6/9/pubmed PY - 2007/7/12/medline PY - 2007/6/9/entrez SP - 1527 EP - 32 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 85 IS - 6 N2 - BACKGROUND: Low-fat, high-carbohydrate (LFHC) diets have been shown to increase plasma concentrations of lipoprotein(a) [Lp(a)] and of triacylglycerol- rich lipoproteins (TRLs). OBJECTIVE: We tested whether increases in plasma Lp(a) induced by an LFHC diet are related to changes in TRLs. DESIGN: Healthy men (study 1; n = 140) consumed for 4 wk each a high-fat, low-carbohydrate diet (HFLC; 40% fat, 45% carbohydrate) and an LFHC diet (20% fat, 65% carbohydrate). Plasma lipids; lipoproteins; apolipoprotein (apo) B, A-I, and C-III; and Lp(a) were measured at the end of each diet. In a second group of men following a similar dietary protocol (study 2; n = 33), we isolated apo(a)-containing particles by immunoaffinity chromatography and determined the concentrations of apo C-III in ultracentrifugally isolated subfractions of apo B-containing lipoproteins. RESULTS: In study 1, plasma concentrations of Lp(a) (P < 0.001), triacylglycerol (P < 0.001), apo B (P < 0.005), apo C-III (P < 0.005), and apo C-III in apo B-containing lipoproteins (non-HDL apo C-III) (P < 0.001) were significantly higher with the LFHC diet than with the HFLC diet. Stepwise multiple linear regression analysis showed that the association of changes in Lp(a) with changes in non-HDL apo C-III was independent of changes in body mass index, apo B, LDL cholesterol, and HDL cholesterol. Plasma lipid and lipoprotein changes were similar in study 2, and we found that both total apo C-III and the apo C-III content of apo(a)-containing particles were increased in a TRL fraction consisting predominantly of large VLDL particles [TRL-apo(a)]. CONCLUSIONS: The increase in plasma Lp(a) with an LFHC diet is significantly associated with an increase in non-HDL apo C-III. Enrichment of TRL-apo(a) with apo C-III may contribute to this dietary effect on Lp(a) concentrations. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/17556688/Increased_plasma_concentrations_of_lipoprotein_a__during_a_low_fat_high_carbohydrate_diet_are_associated_with_increased_plasma_concentrations_of_apolipoprotein_C_III_bound_to_apolipoprotein_B_containing_lipoproteins_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/85.6.1527 DB - PRIME DP - Unbound Medicine ER -