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Non-pharmacologic prevention of Alzheimer's disease: nutritional and life-style risk factors.
J Neural Transm (Vienna). 2007 Sep; 114(9):1187-97.JN

Abstract

We conducted a review of cohort studies and interventional studies on nutritional and life-style risk factors and primary prevention of Alzheimer's Disease. Studies were assessed by the Oxford classification. Interventional studies exist for mental training and vitamin supplementation. For alcohol, fat and fish intake, mediterranean diet, homocysteine, overweight/caloric intake, physical and social activity, hypercholesterolemia, diabetes and smoking, currently there is only evidence from cohort studies. Cognitive stimulation by mental training increases mental functions and can be recommended on the basis of positive interventional studies. Vitamin supplementation cannot prevent AD on the basis of interventional studies. Hyperlipidemia, hyperhomocysteinemia, diabetes and typical life-style factors (alcohol, smoking, obesity etc.) modestly increased AD risk, fish, mediterranean diet and unsaturated fat or n-3 fatty acids and social activity are protective in observational cohorts, but interventional studies are lacking.

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Authors+Show Affiliations

Weih M
Department of Psychiatry and Psychotherapy, Friedrich-Alexander University, Erlangen, Germany. markus.weih@uk-erlangen.de
Wiltfang J
No affiliation info available
Kornhuber J
No affiliation info available

MeSH

Alzheimer DiseaseDietary SupplementsHumansLife StyleNutritional StatusRisk Factors

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17557131

Citation

Weih, M, et al. "Non-pharmacologic Prevention of Alzheimer's Disease: Nutritional and Life-style Risk Factors." Journal of Neural Transmission (Vienna, Austria : 1996), vol. 114, no. 9, 2007, pp. 1187-97.
Weih M, Wiltfang J, Kornhuber J. Non-pharmacologic prevention of Alzheimer's disease: nutritional and life-style risk factors. J Neural Transm (Vienna). 2007;114(9):1187-97.
Weih, M., Wiltfang, J., & Kornhuber, J. (2007). Non-pharmacologic prevention of Alzheimer's disease: nutritional and life-style risk factors. Journal of Neural Transmission (Vienna, Austria : 1996), 114(9), 1187-97.
Weih M, Wiltfang J, Kornhuber J. Non-pharmacologic Prevention of Alzheimer's Disease: Nutritional and Life-style Risk Factors. J Neural Transm (Vienna). 2007;114(9):1187-97. PubMed PMID: 17557131.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Non-pharmacologic prevention of Alzheimer's disease: nutritional and life-style risk factors. AU - Weih,M, AU - Wiltfang,J, AU - Kornhuber,J, Y1 - 2007/06/08/ PY - 2006/09/01/received PY - 2007/02/23/accepted PY - 2007/6/9/pubmed PY - 2009/12/16/medline PY - 2007/6/9/entrez SP - 1187 EP - 97 JF - Journal of neural transmission (Vienna, Austria : 1996) JO - J Neural Transm (Vienna) VL - 114 IS - 9 N2 - We conducted a review of cohort studies and interventional studies on nutritional and life-style risk factors and primary prevention of Alzheimer's Disease. Studies were assessed by the Oxford classification. Interventional studies exist for mental training and vitamin supplementation. For alcohol, fat and fish intake, mediterranean diet, homocysteine, overweight/caloric intake, physical and social activity, hypercholesterolemia, diabetes and smoking, currently there is only evidence from cohort studies. Cognitive stimulation by mental training increases mental functions and can be recommended on the basis of positive interventional studies. Vitamin supplementation cannot prevent AD on the basis of interventional studies. Hyperlipidemia, hyperhomocysteinemia, diabetes and typical life-style factors (alcohol, smoking, obesity etc.) modestly increased AD risk, fish, mediterranean diet and unsaturated fat or n-3 fatty acids and social activity are protective in observational cohorts, but interventional studies are lacking. SN - 1435-1463 UR - https://www.unboundmedicine.com/medline/citation/17557131/Non_pharmacologic_prevention_of_Alzheimer's_disease:_nutritional_and_life_style_risk_factors_ L2 - https://doi.org/10.1007/s00702-007-0704-x DB - PRIME DP - Unbound Medicine ER -