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Dietary fiber and colorectal cancer risk: the multiethnic cohort study.

Abstract

OBJECTIVE

To investigate the association of dietary fiber with colorectal cancer

METHODS

A total of 85,903 men and 105,108 women completed a quantitative food frequency questionnaire in 1993-1996. A total of 1,138 men and 972 women were subsequently diagnosed with adenocarcinoma of the large bowel. Cox proportional hazards models were used to calculate multivariate adjusted relative risks (RR) and 95% confidence intervals (95% CI) for colorectal cancer.

RESULTS

High consumers of dietary fiber were more active, less overweight, and less likely to be cigarette smokers than low consumers in both sexes. Fiber was inversely associated with colorectal cancer risk after adjustment for age and ethnicity in men (RR = 0.49; 95% CI, 0.41-0.60, highest vs. lowest quintile) and women (RR = 0.75; 95% CI, 0.61-0.92). After further adjustment for lifestyle and dietary factors, the inverse association remained significant in men (RR = 0.62; 95% CI, 0.48-0.79), but not in women (RR = 0.88; 95% CI, 0.67-1.14). Adjustment for the combination of replacement hormone use with either cigarette smoking or body mass index accounted for the lack of association with fiber in women.

CONCLUSION

Dietary fiber was inversely associated with colorectal cancer risk in men, but its relation to replacement hormone use and other factors affected its inverse association in women.

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  • Authors+Show Affiliations

    ,

    Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA. abe@crch.hawaii.edu.

    , , , , , , , ,

    Source

    Cancer causes & control : CCC 18:7 2007 Sep pg 753-64

    MeSH

    Adenocarcinoma
    Aged
    Cohort Studies
    Colorectal Neoplasms
    Dietary Fiber
    Female
    Humans
    Incidence
    Male
    Middle Aged
    Population Groups
    Risk Factors

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    17557210

    Citation

    Nomura, Abraham M Y., et al. "Dietary Fiber and Colorectal Cancer Risk: the Multiethnic Cohort Study." Cancer Causes & Control : CCC, vol. 18, no. 7, 2007, pp. 753-64.
    Nomura AM, Hankin JH, Henderson BE, et al. Dietary fiber and colorectal cancer risk: the multiethnic cohort study. Cancer Causes Control. 2007;18(7):753-64.
    Nomura, A. M., Hankin, J. H., Henderson, B. E., Wilkens, L. R., Murphy, S. P., Pike, M. C., ... Kolonel, L. N. (2007). Dietary fiber and colorectal cancer risk: the multiethnic cohort study. Cancer Causes & Control : CCC, 18(7), pp. 753-64.
    Nomura AM, et al. Dietary Fiber and Colorectal Cancer Risk: the Multiethnic Cohort Study. Cancer Causes Control. 2007;18(7):753-64. PubMed PMID: 17557210.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary fiber and colorectal cancer risk: the multiethnic cohort study. AU - Nomura,Abraham M Y, AU - Hankin,Jean H, AU - Henderson,Brian E, AU - Wilkens,Lynne R, AU - Murphy,Suzanne P, AU - Pike,Malcolm C, AU - Le Marchand,Loic, AU - Stram,Daniel O, AU - Monroe,Kristine R, AU - Kolonel,Laurence N, Y1 - 2007/06/08/ PY - 2006/12/31/received PY - 2007/04/25/accepted PY - 2007/6/9/pubmed PY - 2007/8/30/medline PY - 2007/6/9/entrez SP - 753 EP - 64 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 18 IS - 7 N2 - OBJECTIVE: To investigate the association of dietary fiber with colorectal cancer METHODS: A total of 85,903 men and 105,108 women completed a quantitative food frequency questionnaire in 1993-1996. A total of 1,138 men and 972 women were subsequently diagnosed with adenocarcinoma of the large bowel. Cox proportional hazards models were used to calculate multivariate adjusted relative risks (RR) and 95% confidence intervals (95% CI) for colorectal cancer. RESULTS: High consumers of dietary fiber were more active, less overweight, and less likely to be cigarette smokers than low consumers in both sexes. Fiber was inversely associated with colorectal cancer risk after adjustment for age and ethnicity in men (RR = 0.49; 95% CI, 0.41-0.60, highest vs. lowest quintile) and women (RR = 0.75; 95% CI, 0.61-0.92). After further adjustment for lifestyle and dietary factors, the inverse association remained significant in men (RR = 0.62; 95% CI, 0.48-0.79), but not in women (RR = 0.88; 95% CI, 0.67-1.14). Adjustment for the combination of replacement hormone use with either cigarette smoking or body mass index accounted for the lack of association with fiber in women. CONCLUSION: Dietary fiber was inversely associated with colorectal cancer risk in men, but its relation to replacement hormone use and other factors affected its inverse association in women. SN - 0957-5243 UR - https://www.unboundmedicine.com/medline/citation/17557210/full_citation L2 - https://doi.org/10.1007/s10552-007-9018-4 DB - PRIME DP - Unbound Medicine ER -