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Immunisation against ovine caseous lymphadenitis: correlation between Corynebacterium pseudotuberculosis toxoid content and protective efficacy in combined clostridial-corynebacterial vaccines.
Aust Vet J. 1991 Oct; 68(10):322-5.AV

Abstract

Groups of sheep were dosed with vaccines containing Corynebacterium pseudotuberculosis toxoid combined in varying amounts with 5 clostridial antigens. Resistance of the sheep to infection with C pseudotuberculosis was tested at 1, 6 and 12 months after vaccination by infection with pus from ovine lymph glands actively infected with C pseudotuberculosis. The outcome was assessed 3 months after challenge by slaughter and inspection of the sheep for caseous lymphadenitis lesions. Protection was demonstrated by a significant reduction in the proportion of immunised sheep exhibiting lesions compared with control sheep, and by fewer abscesses in affected immunised sheep than in affected control sheep. A positive correlation was found between amount of C pseudotuberculosis toxoid administered and degree of protection obtained. Chromatographically-purified toxoid induced essentially the same protection, suggesting that anti-toxic immunity is the major factor in protection.

Authors+Show Affiliations

Commonwealth Serum Laboratories, Parkville, Victoria.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1755783

Citation

Eggleton, D G., et al. "Immunisation Against Ovine Caseous Lymphadenitis: Correlation Between Corynebacterium Pseudotuberculosis Toxoid Content and Protective Efficacy in Combined Clostridial-corynebacterial Vaccines." Australian Veterinary Journal, vol. 68, no. 10, 1991, pp. 322-5.
Eggleton DG, Haynes JA, Middleton HD, et al. Immunisation against ovine caseous lymphadenitis: correlation between Corynebacterium pseudotuberculosis toxoid content and protective efficacy in combined clostridial-corynebacterial vaccines. Aust Vet J. 1991;68(10):322-5.
Eggleton, D. G., Haynes, J. A., Middleton, H. D., & Cox, J. C. (1991). Immunisation against ovine caseous lymphadenitis: correlation between Corynebacterium pseudotuberculosis toxoid content and protective efficacy in combined clostridial-corynebacterial vaccines. Australian Veterinary Journal, 68(10), 322-5.
Eggleton DG, et al. Immunisation Against Ovine Caseous Lymphadenitis: Correlation Between Corynebacterium Pseudotuberculosis Toxoid Content and Protective Efficacy in Combined Clostridial-corynebacterial Vaccines. Aust Vet J. 1991;68(10):322-5. PubMed PMID: 1755783.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunisation against ovine caseous lymphadenitis: correlation between Corynebacterium pseudotuberculosis toxoid content and protective efficacy in combined clostridial-corynebacterial vaccines. AU - Eggleton,D G, AU - Haynes,J A, AU - Middleton,H D, AU - Cox,J C, PY - 1991/10/1/pubmed PY - 1991/10/1/medline PY - 1991/10/1/entrez SP - 322 EP - 5 JF - Australian veterinary journal JO - Aust. Vet. J. VL - 68 IS - 10 N2 - Groups of sheep were dosed with vaccines containing Corynebacterium pseudotuberculosis toxoid combined in varying amounts with 5 clostridial antigens. Resistance of the sheep to infection with C pseudotuberculosis was tested at 1, 6 and 12 months after vaccination by infection with pus from ovine lymph glands actively infected with C pseudotuberculosis. The outcome was assessed 3 months after challenge by slaughter and inspection of the sheep for caseous lymphadenitis lesions. Protection was demonstrated by a significant reduction in the proportion of immunised sheep exhibiting lesions compared with control sheep, and by fewer abscesses in affected immunised sheep than in affected control sheep. A positive correlation was found between amount of C pseudotuberculosis toxoid administered and degree of protection obtained. Chromatographically-purified toxoid induced essentially the same protection, suggesting that anti-toxic immunity is the major factor in protection. SN - 0005-0423 UR - https://www.unboundmedicine.com/medline/citation/1755783/Immunisation_against_ovine_caseous_lymphadenitis:_correlation_between_Corynebacterium_pseudotuberculosis_toxoid_content_and_protective_efficacy_in_combined_clostridial_corynebacterial_vaccines_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0005-0423&date=1991&volume=68&issue=10&spage=322 DB - PRIME DP - Unbound Medicine ER -