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Rhapontigenin from Rheum undulatum protects against oxidative-stress-induced cell damage through antioxidant activity.
J Toxicol Environ Health A. 2007 Jul; 70(13):1155-66.JT

Abstract

The antioxidant properties of rhapontigenin and rhaponticin isolated from Rheum undulatum were investigated. Rhapontigenin was found to scavenge intracellular reactive oxygen species (ROS), the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, and hydrogen peroxide (H2O2). The radical scavenging effect of rhapontigenin was more effective than rhaponticin. Rhapontigenin protected against H2O2-induced membrane lipid peroxidation and cellular DNA damage, which are the main targets of oxidative stress-induced cellular damage. The radical scavenging activity of rhapontigenin protected Chinese hamster lung fibroblast (V79-4) cells exposed to H2O2 by inhibiting apoptosis. Rhapontigenin inhibited cell damage induced by serum starvation and was also found to increase the activity of catalase and its protein expression. Further, rhapontigenin increased phosphorylation of extracellular signal-regulated kinase (ERK) and inhibited the activity of activator protein 1 (AP-1), a redox-sensitive transcription factor. In summary, these results suggest that rhapontigenin protects V79-4 cells against oxidative damage by enhancing the cellular antioxidant activity and modulating cellular signal pathways.

Authors+Show Affiliations

Department of Biochemistry, College of Medicine and Applied Radiological Science Research Institute, Cheju National University, Jeju-si, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17558811

Citation

Zhang, Rui, et al. "Rhapontigenin From Rheum Undulatum Protects Against Oxidative-stress-induced Cell Damage Through Antioxidant Activity." Journal of Toxicology and Environmental Health. Part A, vol. 70, no. 13, 2007, pp. 1155-66.
Zhang R, Kang KA, Piao MJ, et al. Rhapontigenin from Rheum undulatum protects against oxidative-stress-induced cell damage through antioxidant activity. J Toxicol Environ Health A. 2007;70(13):1155-66.
Zhang, R., Kang, K. A., Piao, M. J., Lee, K. H., Jang, H. S., Park, M. J., Kim, B. J., Kim, J. S., Kim, Y. S., Ryu, S. Y., & Hyun, J. W. (2007). Rhapontigenin from Rheum undulatum protects against oxidative-stress-induced cell damage through antioxidant activity. Journal of Toxicology and Environmental Health. Part A, 70(13), 1155-66.
Zhang R, et al. Rhapontigenin From Rheum Undulatum Protects Against Oxidative-stress-induced Cell Damage Through Antioxidant Activity. J Toxicol Environ Health A. 2007;70(13):1155-66. PubMed PMID: 17558811.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rhapontigenin from Rheum undulatum protects against oxidative-stress-induced cell damage through antioxidant activity. AU - Zhang,Rui, AU - Kang,Kyoung Ah, AU - Piao,Mei Jing, AU - Lee,Kyoung Hwa, AU - Jang,Hye Suk, AU - Park,Min Jeong, AU - Kim,Bum Joon, AU - Kim,Jin Sook, AU - Kim,Young Sup, AU - Ryu,Shi Yong, AU - Hyun,Jin Won, PY - 2007/6/15/pubmed PY - 2007/6/21/medline PY - 2007/6/15/entrez SP - 1155 EP - 66 JF - Journal of toxicology and environmental health. Part A JO - J Toxicol Environ Health A VL - 70 IS - 13 N2 - The antioxidant properties of rhapontigenin and rhaponticin isolated from Rheum undulatum were investigated. Rhapontigenin was found to scavenge intracellular reactive oxygen species (ROS), the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, and hydrogen peroxide (H2O2). The radical scavenging effect of rhapontigenin was more effective than rhaponticin. Rhapontigenin protected against H2O2-induced membrane lipid peroxidation and cellular DNA damage, which are the main targets of oxidative stress-induced cellular damage. The radical scavenging activity of rhapontigenin protected Chinese hamster lung fibroblast (V79-4) cells exposed to H2O2 by inhibiting apoptosis. Rhapontigenin inhibited cell damage induced by serum starvation and was also found to increase the activity of catalase and its protein expression. Further, rhapontigenin increased phosphorylation of extracellular signal-regulated kinase (ERK) and inhibited the activity of activator protein 1 (AP-1), a redox-sensitive transcription factor. In summary, these results suggest that rhapontigenin protects V79-4 cells against oxidative damage by enhancing the cellular antioxidant activity and modulating cellular signal pathways. SN - 1528-7394 UR - https://www.unboundmedicine.com/medline/citation/17558811/Rhapontigenin_from_Rheum_undulatum_protects_against_oxidative_stress_induced_cell_damage_through_antioxidant_activity_ DB - PRIME DP - Unbound Medicine ER -