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Methylenetetrahydrofolate reductase genetic polymorphisms in patients with primary open-angle glaucoma.
Ophthalmic Genet. 2007 Jun; 28(2):47-50.OG

Abstract

PURPOSE

Hyperhomocysteinemia has been found in patients with primary open-angle glaucoma. The purpose of the present study was to determine if hyperhomocysteinemia-associated polymorphisms of the methylenetetrahydrofolate reductase gene (MTHFR) are overrepresented in primary open-angle glaucoma.

METHODS

Patients with primary open-angle glaucoma (n = 243) and controls (n = 187) were analyzed for the MTHFR 677 C > T and 1298 A > C polymorphisms using minisequencing technique.

RESULTS

No significant differences were observed in allele and genotype frequencies of the MTHFR 677C > T and 1298A > C polymorphisms between controls and the primary open-angle glaucoma group.

CONCLUSIONS

If hyperhomocysteinemia is important in the pathogenesis of glaucoma, this study does not support a role for MTHFR polymorphisms in this context.

Authors+Show Affiliations

Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation, Section of Ophthalmology, The Sahlgrenska Academy at Göteborg University, Mölndal, Sweden. madeleine.zetterberg@gu.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17558844

Citation

Zetterberg, Madeleine, et al. "Methylenetetrahydrofolate Reductase Genetic Polymorphisms in Patients With Primary Open-angle Glaucoma." Ophthalmic Genetics, vol. 28, no. 2, 2007, pp. 47-50.
Zetterberg M, Tasa G, Palmér MS, et al. Methylenetetrahydrofolate reductase genetic polymorphisms in patients with primary open-angle glaucoma. Ophthalmic Genet. 2007;28(2):47-50.
Zetterberg, M., Tasa, G., Palmér, M. S., Juronen, E., Toover, E., Blennow, K., & Zetterberg, H. (2007). Methylenetetrahydrofolate reductase genetic polymorphisms in patients with primary open-angle glaucoma. Ophthalmic Genetics, 28(2), 47-50.
Zetterberg M, et al. Methylenetetrahydrofolate Reductase Genetic Polymorphisms in Patients With Primary Open-angle Glaucoma. Ophthalmic Genet. 2007;28(2):47-50. PubMed PMID: 17558844.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Methylenetetrahydrofolate reductase genetic polymorphisms in patients with primary open-angle glaucoma. AU - Zetterberg,Madeleine, AU - Tasa,Gunnar, AU - Palmér,Mona Seibt, AU - Juronen,Erkki, AU - Toover,Egle, AU - Blennow,Kaj, AU - Zetterberg,Henrik, PY - 2007/6/15/pubmed PY - 2007/8/19/medline PY - 2007/6/15/entrez SP - 47 EP - 50 JF - Ophthalmic genetics JO - Ophthalmic Genet VL - 28 IS - 2 N2 - PURPOSE: Hyperhomocysteinemia has been found in patients with primary open-angle glaucoma. The purpose of the present study was to determine if hyperhomocysteinemia-associated polymorphisms of the methylenetetrahydrofolate reductase gene (MTHFR) are overrepresented in primary open-angle glaucoma. METHODS: Patients with primary open-angle glaucoma (n = 243) and controls (n = 187) were analyzed for the MTHFR 677 C > T and 1298 A > C polymorphisms using minisequencing technique. RESULTS: No significant differences were observed in allele and genotype frequencies of the MTHFR 677C > T and 1298A > C polymorphisms between controls and the primary open-angle glaucoma group. CONCLUSIONS: If hyperhomocysteinemia is important in the pathogenesis of glaucoma, this study does not support a role for MTHFR polymorphisms in this context. SN - 1381-6810 UR - https://www.unboundmedicine.com/medline/citation/17558844/Methylenetetrahydrofolate_reductase_genetic_polymorphisms_in_patients_with_primary_open_angle_glaucoma_ L2 - https://www.tandfonline.com/doi/full/10.1080/13816810701329046 DB - PRIME DP - Unbound Medicine ER -