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Maintained malnutrition produces a progressive decrease in (OPG)/RANKL ratio and leptin levels in patients with anorexia nervosa.
Scand J Clin Lab Invest 2007; 67(4):387-93SJ

Abstract

OBJECTIVE

Osteoprotegerin (OPG) and receptor activator of nuclear factor-kappaB ligand (RANKL) are key factors in bone remodeling in patients with anorexia nervosa (AN) and osteopenia. The purpose of this study was to investigate basal serum levels of OPG, RANKL and leptin, as well as bone mineral density (BMD) measured by DEXA at lumbar vertebrae L1-L4, and their evolution during one year in two groups of patients with AN.

MATERIAL AND METHODS

Group I included 10 adolescent girls suffering from malnutrition and secondary amenorrhea with an evolution of more than one year at the beginning of the study who received oral estrogen treatment throughout the follow-up period. Group II comprised 10 girls with malnutrition and secondary amenorrhea with an evolution of less than one year who received nutritional treatment only. All parameters were compared with those of a control group of 19 healthy, age-matched girls with normal BMI and regular menstrual cycles.

RESULTS

The OPG/RANKL ratio was significantly decreased (p<0.05) after 1 year in group I, a fact that was due to an increase (p<0.05) in serum RANKL values. A correlation between OPG/RANKL and BMD was found in group I at the beginning of the study (r = 0.95; p<0.001). Patients in this group showed lower BMD values (p<0.01), both at diagnosis and at the end of the study, than those of group II patients, who showed normal BMD values.

CONCLUSION

The decrease in the OPG/RANKL ratio in girls with AN could partly explain the increase in bone loss that occurs in these patients.

Authors+Show Affiliations

Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Universidad Autónoma, Madrid, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17558893

Citation

Muñoz-Calvo, M T., et al. "Maintained Malnutrition Produces a Progressive Decrease in (OPG)/RANKL Ratio and Leptin Levels in Patients With Anorexia Nervosa." Scandinavian Journal of Clinical and Laboratory Investigation, vol. 67, no. 4, 2007, pp. 387-93.
Muñoz-Calvo MT, Barrios V, García de Alvaro MT, et al. Maintained malnutrition produces a progressive decrease in (OPG)/RANKL ratio and leptin levels in patients with anorexia nervosa. Scand J Clin Lab Invest. 2007;67(4):387-93.
Muñoz-Calvo, M. T., Barrios, V., García de Alvaro, M. T., Lefort, M., Méndez-Dávila, C., Argente, J., & de la Piedra, C. (2007). Maintained malnutrition produces a progressive decrease in (OPG)/RANKL ratio and leptin levels in patients with anorexia nervosa. Scandinavian Journal of Clinical and Laboratory Investigation, 67(4), pp. 387-93.
Muñoz-Calvo MT, et al. Maintained Malnutrition Produces a Progressive Decrease in (OPG)/RANKL Ratio and Leptin Levels in Patients With Anorexia Nervosa. Scand J Clin Lab Invest. 2007;67(4):387-93. PubMed PMID: 17558893.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maintained malnutrition produces a progressive decrease in (OPG)/RANKL ratio and leptin levels in patients with anorexia nervosa. AU - Muñoz-Calvo,M T, AU - Barrios,V, AU - García de Alvaro,M T, AU - Lefort,M, AU - Méndez-Dávila,C, AU - Argente,J, AU - de la Piedra,C, PY - 2007/6/15/pubmed PY - 2007/9/22/medline PY - 2007/6/15/entrez SP - 387 EP - 93 JF - Scandinavian journal of clinical and laboratory investigation JO - Scand. J. Clin. Lab. Invest. VL - 67 IS - 4 N2 - OBJECTIVE: Osteoprotegerin (OPG) and receptor activator of nuclear factor-kappaB ligand (RANKL) are key factors in bone remodeling in patients with anorexia nervosa (AN) and osteopenia. The purpose of this study was to investigate basal serum levels of OPG, RANKL and leptin, as well as bone mineral density (BMD) measured by DEXA at lumbar vertebrae L1-L4, and their evolution during one year in two groups of patients with AN. MATERIAL AND METHODS: Group I included 10 adolescent girls suffering from malnutrition and secondary amenorrhea with an evolution of more than one year at the beginning of the study who received oral estrogen treatment throughout the follow-up period. Group II comprised 10 girls with malnutrition and secondary amenorrhea with an evolution of less than one year who received nutritional treatment only. All parameters were compared with those of a control group of 19 healthy, age-matched girls with normal BMI and regular menstrual cycles. RESULTS: The OPG/RANKL ratio was significantly decreased (p<0.05) after 1 year in group I, a fact that was due to an increase (p<0.05) in serum RANKL values. A correlation between OPG/RANKL and BMD was found in group I at the beginning of the study (r = 0.95; p<0.001). Patients in this group showed lower BMD values (p<0.01), both at diagnosis and at the end of the study, than those of group II patients, who showed normal BMD values. CONCLUSION: The decrease in the OPG/RANKL ratio in girls with AN could partly explain the increase in bone loss that occurs in these patients. SN - 0036-5513 UR - https://www.unboundmedicine.com/medline/citation/17558893/Maintained_malnutrition_produces_a_progressive_decrease_in__OPG_/RANKL_ratio_and_leptin_levels_in_patients_with_anorexia_nervosa_ L2 - http://www.tandfonline.com/doi/full/10.1080/00365510601110130 DB - PRIME DP - Unbound Medicine ER -