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Relevance of ineffective esophageal motility and hyperactive acid sensitization in patients with gastroesophageal reflux.
J Gastroenterol Hepatol. 2007 Oct; 22(10):1662-5.JG

Abstract

BACKGROUND AND AIM

Esophageal motor abnormalities including ineffective esophageal motility (IEM) and visceral hypersensitivity have been frequently observed in patients with gastroesophageal reflux. The aim of this study was to observe the incidences of hypersensitivity to acid infusion and motor abnormalities in non-erosive reflux disease (NERD) compared with erosive esophagitis.

METHODS

We performed upper GI endoscopy, an acid perfusion test and esophageal manometry on 113 NERD patients and 37 erosive esophagitis patients.

RESULTS

The frequency of acid sensitization was 69.9% in NERD and 67.6% in erosive esophagitis. The frequency of esophageal motor abnormality in patients with erosive esophagitis (48.6%) was higher than in patients with NERD (25.7%, P = 0.014). The most frequent esophageal motor abnormality was IEM. The frequency of IEM was 15.9% in NERD patients, 42.9% in Los Angeles grade A, 53.8% in Los Angeles grade B and 66.7% in Los Angeles grade C esophagitis (chi(2) = 16.67, P < 0.0001).

CONCLUSION

Our results suggest that no difference exists between visceral hypersensitivity in patients with NERD and those with erosive esophagitis, and that IEM occurs in NERD as well as erosive esophagitis patients. The occurrence of IEM is associated with the endoscopic severity of gastroesophageal reflux disease.

Authors+Show Affiliations

Department of Gastroenterology, Institute for Digestive Research, Soonchunhyang University College of Medicine, Bucheon, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17559356

Citation

Hong, Su Jin, et al. "Relevance of Ineffective Esophageal Motility and Hyperactive Acid Sensitization in Patients With Gastroesophageal Reflux." Journal of Gastroenterology and Hepatology, vol. 22, no. 10, 2007, pp. 1662-5.
Hong SJ, Ko BM, Jung IS, et al. Relevance of ineffective esophageal motility and hyperactive acid sensitization in patients with gastroesophageal reflux. J Gastroenterol Hepatol. 2007;22(10):1662-5.
Hong, S. J., Ko, B. M., Jung, I. S., Ryu, C. B., Moon, J. H., Cho, J. Y., Kim, J. O., Lee, J. S., Lee, M. S., Shim, C. S., & Kim, B. S. (2007). Relevance of ineffective esophageal motility and hyperactive acid sensitization in patients with gastroesophageal reflux. Journal of Gastroenterology and Hepatology, 22(10), 1662-5.
Hong SJ, et al. Relevance of Ineffective Esophageal Motility and Hyperactive Acid Sensitization in Patients With Gastroesophageal Reflux. J Gastroenterol Hepatol. 2007;22(10):1662-5. PubMed PMID: 17559356.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relevance of ineffective esophageal motility and hyperactive acid sensitization in patients with gastroesophageal reflux. AU - Hong,Su Jin, AU - Ko,Bong Min, AU - Jung,In Seop, AU - Ryu,Chang Beom, AU - Moon,Jong Ho, AU - Cho,Joo Young, AU - Kim,Jin Oh, AU - Lee,Joon Seong, AU - Lee,Moon Sung, AU - Shim,Chan Sup, AU - Kim,Boo Sung, Y1 - 2007/06/07/ PY - 2007/6/15/pubmed PY - 2008/1/25/medline PY - 2007/6/15/entrez SP - 1662 EP - 5 JF - Journal of gastroenterology and hepatology JO - J. Gastroenterol. Hepatol. VL - 22 IS - 10 N2 - BACKGROUND AND AIM: Esophageal motor abnormalities including ineffective esophageal motility (IEM) and visceral hypersensitivity have been frequently observed in patients with gastroesophageal reflux. The aim of this study was to observe the incidences of hypersensitivity to acid infusion and motor abnormalities in non-erosive reflux disease (NERD) compared with erosive esophagitis. METHODS: We performed upper GI endoscopy, an acid perfusion test and esophageal manometry on 113 NERD patients and 37 erosive esophagitis patients. RESULTS: The frequency of acid sensitization was 69.9% in NERD and 67.6% in erosive esophagitis. The frequency of esophageal motor abnormality in patients with erosive esophagitis (48.6%) was higher than in patients with NERD (25.7%, P = 0.014). The most frequent esophageal motor abnormality was IEM. The frequency of IEM was 15.9% in NERD patients, 42.9% in Los Angeles grade A, 53.8% in Los Angeles grade B and 66.7% in Los Angeles grade C esophagitis (chi(2) = 16.67, P < 0.0001). CONCLUSION: Our results suggest that no difference exists between visceral hypersensitivity in patients with NERD and those with erosive esophagitis, and that IEM occurs in NERD as well as erosive esophagitis patients. The occurrence of IEM is associated with the endoscopic severity of gastroesophageal reflux disease. SN - 0815-9319 UR - https://www.unboundmedicine.com/medline/citation/17559356/Relevance_of_ineffective_esophageal_motility_and_hyperactive_acid_sensitization_in_patients_with_gastroesophageal_reflux_ L2 - https://doi.org/10.1111/j.1440-1746.2007.04987.x DB - PRIME DP - Unbound Medicine ER -