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Olive oil containing olive oil fatty acid esters of plant sterols and dietary diacylglycerol reduces low-density lipoprotein cholesterol and decreases the tendency for peroxidation in hypercholesterolaemic subjects.
Br J Nutr. 2007 Sep; 98(3):563-70.BJ

Abstract

Plant sterols (PS) and MUFA are well-documented cholesterol lowering agents. We aimed to determine the effect of PS esterified to olive oil fatty acids (PS-OO) on blood lipid profile and lipid peroxidation in hypercholesterolaemic subjects. Twenty-one moderately overweight, hypercholesterolaemic subjects consumed three consecutive treatment diets, each lasting 28 d and separated by 4-week washout periods, using a randomized crossover design. Diets contained 30 % energy as fat, 70 % of which was provided by olive oil (OO), and differed only in the treatment oils: OO, PS esterified to sunflower oil fatty acids (PS-SO), and PS-OO. Both PS-SO and PS-OO treatments provided 1.7 g PS /d. PS-OO and PS-SO consumption resulted in a decrease (P = 0.0483) in LDL-cholesterol (LDL-C) concentrations compared with the OO diet. Although total cholesterol and apo B-100 levels were not significantly affected, PS-SO and, to some extent, PS-OO reduced the total:HDL-cholesterol (HDL-C) ratio (P = 0.0142) and the apo B-100:apo A-I ratio (P = 0.0168) compared with the OO diet. There were no differences across diets in lipoprotein(a) (Lp(a)) and lipid peroxidation levels. However, following consumption of OO and PS-SO, Lp(a) concentrations increased (P = 0.0050 and 0.0421, respectively), while PS-OO treatment did not affect Lp(a) levels. Furthermore, there was a decrease (P = 0.0097) in lipid peroxidation levels with PS-OO treatment during the supplementation phase. Our results suggest that supplementing an OO-rich diet with PS-OO favourably alters the plasma lipid profile and may decrease the susceptibility of LDL-C to lipid peroxidation in hypercholesterolaemic subjects.

Authors+Show Affiliations

The School of Dietetics and Human Nutrition, McGill University, Macdonald Campus, 21,111 Lakeshore Road, Sainte-Anne-de-Bellevue, Quebec, Canada H9X 3V9.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17559697

Citation

Chan, Yen-Ming, et al. "Olive Oil Containing Olive Oil Fatty Acid Esters of Plant Sterols and Dietary Diacylglycerol Reduces Low-density Lipoprotein Cholesterol and Decreases the Tendency for Peroxidation in Hypercholesterolaemic Subjects." The British Journal of Nutrition, vol. 98, no. 3, 2007, pp. 563-70.
Chan YM, Demonty I, Pelled D, et al. Olive oil containing olive oil fatty acid esters of plant sterols and dietary diacylglycerol reduces low-density lipoprotein cholesterol and decreases the tendency for peroxidation in hypercholesterolaemic subjects. Br J Nutr. 2007;98(3):563-70.
Chan, Y. M., Demonty, I., Pelled, D., & Jones, P. J. (2007). Olive oil containing olive oil fatty acid esters of plant sterols and dietary diacylglycerol reduces low-density lipoprotein cholesterol and decreases the tendency for peroxidation in hypercholesterolaemic subjects. The British Journal of Nutrition, 98(3), 563-70.
Chan YM, et al. Olive Oil Containing Olive Oil Fatty Acid Esters of Plant Sterols and Dietary Diacylglycerol Reduces Low-density Lipoprotein Cholesterol and Decreases the Tendency for Peroxidation in Hypercholesterolaemic Subjects. Br J Nutr. 2007;98(3):563-70. PubMed PMID: 17559697.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Olive oil containing olive oil fatty acid esters of plant sterols and dietary diacylglycerol reduces low-density lipoprotein cholesterol and decreases the tendency for peroxidation in hypercholesterolaemic subjects. AU - Chan,Yen-Ming, AU - Demonty,Isabelle, AU - Pelled,Dori, AU - Jones,Peter J H, Y1 - 2007/06/11/ PY - 2007/6/15/pubmed PY - 2007/10/6/medline PY - 2007/6/15/entrez SP - 563 EP - 70 JF - The British journal of nutrition JO - Br J Nutr VL - 98 IS - 3 N2 - Plant sterols (PS) and MUFA are well-documented cholesterol lowering agents. We aimed to determine the effect of PS esterified to olive oil fatty acids (PS-OO) on blood lipid profile and lipid peroxidation in hypercholesterolaemic subjects. Twenty-one moderately overweight, hypercholesterolaemic subjects consumed three consecutive treatment diets, each lasting 28 d and separated by 4-week washout periods, using a randomized crossover design. Diets contained 30 % energy as fat, 70 % of which was provided by olive oil (OO), and differed only in the treatment oils: OO, PS esterified to sunflower oil fatty acids (PS-SO), and PS-OO. Both PS-SO and PS-OO treatments provided 1.7 g PS /d. PS-OO and PS-SO consumption resulted in a decrease (P = 0.0483) in LDL-cholesterol (LDL-C) concentrations compared with the OO diet. Although total cholesterol and apo B-100 levels were not significantly affected, PS-SO and, to some extent, PS-OO reduced the total:HDL-cholesterol (HDL-C) ratio (P = 0.0142) and the apo B-100:apo A-I ratio (P = 0.0168) compared with the OO diet. There were no differences across diets in lipoprotein(a) (Lp(a)) and lipid peroxidation levels. However, following consumption of OO and PS-SO, Lp(a) concentrations increased (P = 0.0050 and 0.0421, respectively), while PS-OO treatment did not affect Lp(a) levels. Furthermore, there was a decrease (P = 0.0097) in lipid peroxidation levels with PS-OO treatment during the supplementation phase. Our results suggest that supplementing an OO-rich diet with PS-OO favourably alters the plasma lipid profile and may decrease the susceptibility of LDL-C to lipid peroxidation in hypercholesterolaemic subjects. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/17559697/Olive_oil_containing_olive_oil_fatty_acid_esters_of_plant_sterols_and_dietary_diacylglycerol_reduces_low_density_lipoprotein_cholesterol_and_decreases_the_tendency_for_peroxidation_in_hypercholesterolaemic_subjects_ L2 - https://www.cambridge.org/core/product/identifier/S0007114507730775/type/journal_article DB - PRIME DP - Unbound Medicine ER -