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Strawberry pelargonidin glycosides are excreted in urine as intact glycosides and glucuronidated pelargonidin derivatives in rats.
Br J Nutr. 2007 Dec; 98(6):1126-31.BJ

Abstract

Anthocyanins are natural dietary pigments with a wide array of biological properties that are possibly involved in the prevention of various diseases. These properties depend on their absorption and metabolism in the body. In the present study we first examined the gastric and intestinal absorption of pelargonidin 3-glucoside (Pg 3-glc) using rat in situ models. A high proportion of Pg 3-glc was rapidly absorbed from both the stomach (23 %) and small intestine (24 %). Its metabolism was further studied by feeding rats during 8 d with a diet enriched in freeze-dried strawberries. Only low amounts of total anthocyanins were recovered in 24 h urine (0.163 (SEM 0.013) % of ingested anthocyanins; n 8). Strawberry anthocyanins were analysed in urine by HPLC-electrospray ionisation-tandem MS. Similar proportions of intact glycosides (about 53 %) and glucuronidated metabolites (about 47 %) were found. Pg 3-glc was thus glucuronidated to a larger extent than cyanidin 3-glucoside. These results highlight the influence of the aglycone structure on anthocyanin metabolism.

Authors+Show Affiliations

Felgines C
Université Clermont 1, UFR Pharmacie, Laboratoire de Pharmacognosie, 28 Place Henri Dunant, BP 38, F-63001 Clermont-Ferrand Cedex 1, France. catherine.felgines@u-clermont.fr
Texier O
No affiliation info available
Besson C
No affiliation info available
Lyan B
No affiliation info available
Lamaison JL
No affiliation info available
Scalbert A
No affiliation info available

MeSH

AnimalsAnthocyaninsChromatography, High Pressure LiquidFlavonoidsFragariaGastric MucosaGlucuronidesIntestinal AbsorptionMalePerfusionRatsRats, Wistar

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17559698

Citation

Felgines, Catherine, et al. "Strawberry Pelargonidin Glycosides Are Excreted in Urine as Intact Glycosides and Glucuronidated Pelargonidin Derivatives in Rats." The British Journal of Nutrition, vol. 98, no. 6, 2007, pp. 1126-31.
Felgines C, Texier O, Besson C, et al. Strawberry pelargonidin glycosides are excreted in urine as intact glycosides and glucuronidated pelargonidin derivatives in rats. Br J Nutr. 2007;98(6):1126-31.
Felgines, C., Texier, O., Besson, C., Lyan, B., Lamaison, J. L., & Scalbert, A. (2007). Strawberry pelargonidin glycosides are excreted in urine as intact glycosides and glucuronidated pelargonidin derivatives in rats. The British Journal of Nutrition, 98(6), 1126-31.
Felgines C, et al. Strawberry Pelargonidin Glycosides Are Excreted in Urine as Intact Glycosides and Glucuronidated Pelargonidin Derivatives in Rats. Br J Nutr. 2007;98(6):1126-31. PubMed PMID: 17559698.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Strawberry pelargonidin glycosides are excreted in urine as intact glycosides and glucuronidated pelargonidin derivatives in rats. AU - Felgines,Catherine, AU - Texier,Odile, AU - Besson,Catherine, AU - Lyan,Bernard, AU - Lamaison,Jean-Louis, AU - Scalbert,Augustin, Y1 - 2007/06/11/ PY - 2007/6/15/pubmed PY - 2008/3/14/medline PY - 2007/6/15/entrez SP - 1126 EP - 31 JF - The British journal of nutrition JO - Br J Nutr VL - 98 IS - 6 N2 - Anthocyanins are natural dietary pigments with a wide array of biological properties that are possibly involved in the prevention of various diseases. These properties depend on their absorption and metabolism in the body. In the present study we first examined the gastric and intestinal absorption of pelargonidin 3-glucoside (Pg 3-glc) using rat in situ models. A high proportion of Pg 3-glc was rapidly absorbed from both the stomach (23 %) and small intestine (24 %). Its metabolism was further studied by feeding rats during 8 d with a diet enriched in freeze-dried strawberries. Only low amounts of total anthocyanins were recovered in 24 h urine (0.163 (SEM 0.013) % of ingested anthocyanins; n 8). Strawberry anthocyanins were analysed in urine by HPLC-electrospray ionisation-tandem MS. Similar proportions of intact glycosides (about 53 %) and glucuronidated metabolites (about 47 %) were found. Pg 3-glc was thus glucuronidated to a larger extent than cyanidin 3-glucoside. These results highlight the influence of the aglycone structure on anthocyanin metabolism. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/17559698/Strawberry_pelargonidin_glycosides_are_excreted_in_urine_as_intact_glycosides_and_glucuronidated_pelargonidin_derivatives_in_rats_ DB - PRIME DP - Unbound Medicine ER -