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Effect of zinc supplementation on bone metabolism in male rats chronically exposed to cadmium.
Toxicology. 2007 Jul 31; 237(1-3):89-103.T

Abstract

The aim of the present study is to investigate, based on the rat model of moderate and relatively high human exposure to cadmium (Cd), whether zinc (Zn) supplementation may prevent Cd-induced disorders in bone metabolism. For this purpose, male Wistar rats received Cd (5 and 50mg/l) or/and Zn (30 and 60mg/l) in drinking water for 6 and 12 months. Bone densitometry and biochemical markers of bone turnover were used to assess the effects of Cd or/and Zn. Bone mineral content (BMC) and density (BMD) were measured in the femur. Serum osteocalcin (OC) and alkaline phosphatase in trabecular (bT-ALP) and cortical (bC-ALP) bone were determined as bone formation markers, and carboxy-terminal cross-linking telopeptides of type I collagen (CTX) in serum were measured as bone resorption marker. Serum concentration of calcium (Ca) and its renal handling, as well as Zn and Cd concentrations in the serum/blood, urine and femur were evaluated as well. The exposure to 5 and 50mg Cd/l (0.340+/-0.026 and 2.498+/-0.093mg Cd/kg body wt/24h, respectively), in a dose and duration dependent manner, affected bone turnover (inhibited bone formation and stimulated its resorption) and disturbed bone mineralization (decreased BMC, BMD and Zn concentration). Zn supply at the concentration of 30 and 60mg/l (1.904+/-0.123 and 3.699+/-0.213mg/kg body wt/24h, respectively) during Cd exposure influenced the Cd-induced disorders in bone metabolism. Zn administration to the Cd-exposed rats enhanced the bone ALP activity and prevented Cd-induced bone resorption, but had no statistically significant effect on BMC and BMD; however, mean values of the densitometric parameters in the rats receiving both Cd and Zn were higher than in those treated with Cd alone. Moreover, Zn supplementation at both levels of Cd exposure was found to prevent Cd accumulation in the femur and the Cd-induced decrease in bone Zn concentration. The results of the present study allow the conclusion that Zn supplementation during Cd exposure may partly protect from disorders in bone metabolism. The influence of Zn may be accompanied by its ability to prevent Cd-induced Zn deficiency and to decrease Cd accumulation in bone tissue. The findings seem to indicate that enhanced dietary intake of Zn in subjects chronically exposed to moderate and relatively high Cd levels may have a protective influence on the skeleton.

Authors+Show Affiliations

Department of Toxicology, Medical University of Bialystok, Mickiewicza 2C, 15-222 Bialystok, Poland. Electronic address: mmbr@poczta.onet.pl.Department of Toxicology, Medical University of Bialystok, Mickiewicza 2C, 15-222 Bialystok, Poland.Department of Toxicology, Medical University of Bialystok, Mickiewicza 2C, 15-222 Bialystok, Poland.Department of Toxicology, Medical University of Bialystok, Mickiewicza 2C, 15-222 Bialystok, Poland.Department of Toxicology, Medical University of Bialystok, Mickiewicza 2C, 15-222 Bialystok, Poland.Department of Toxicology, Medical University of Bialystok, Mickiewicza 2C, 15-222 Bialystok, Poland.Department of Toxicology, Medical University of Bialystok, Mickiewicza 2C, 15-222 Bialystok, Poland.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17560002

Citation

Brzóska, Malgorzata M., et al. "Effect of Zinc Supplementation On Bone Metabolism in Male Rats Chronically Exposed to Cadmium." Toxicology, vol. 237, no. 1-3, 2007, pp. 89-103.
Brzóska MM, Rogalska J, Galażyn-Sidorczuk M, et al. Effect of zinc supplementation on bone metabolism in male rats chronically exposed to cadmium. Toxicology. 2007;237(1-3):89-103.
Brzóska, M. M., Rogalska, J., Galażyn-Sidorczuk, M., Jurczuk, M., Roszczenko, A., Kulikowska-Karpińska, E., & Moniuszko-Jakoniuk, J. (2007). Effect of zinc supplementation on bone metabolism in male rats chronically exposed to cadmium. Toxicology, 237(1-3), 89-103. https://doi.org/10.1016/j.tox.2007.05.001
Brzóska MM, et al. Effect of Zinc Supplementation On Bone Metabolism in Male Rats Chronically Exposed to Cadmium. Toxicology. 2007 Jul 31;237(1-3):89-103. PubMed PMID: 17560002.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of zinc supplementation on bone metabolism in male rats chronically exposed to cadmium. AU - Brzóska,Malgorzata M, AU - Rogalska,Joanna, AU - Galażyn-Sidorczuk,Malgorzata, AU - Jurczuk,Maria, AU - Roszczenko,Alicja, AU - Kulikowska-Karpińska,Elżbieta, AU - Moniuszko-Jakoniuk,Janina, Y1 - 2007/05/05/ PY - 2007/03/26/received PY - 2007/04/26/revised PY - 2007/05/01/accepted PY - 2007/6/15/pubmed PY - 2007/9/18/medline PY - 2007/6/15/entrez SP - 89 EP - 103 JF - Toxicology JO - Toxicology VL - 237 IS - 1-3 N2 - The aim of the present study is to investigate, based on the rat model of moderate and relatively high human exposure to cadmium (Cd), whether zinc (Zn) supplementation may prevent Cd-induced disorders in bone metabolism. For this purpose, male Wistar rats received Cd (5 and 50mg/l) or/and Zn (30 and 60mg/l) in drinking water for 6 and 12 months. Bone densitometry and biochemical markers of bone turnover were used to assess the effects of Cd or/and Zn. Bone mineral content (BMC) and density (BMD) were measured in the femur. Serum osteocalcin (OC) and alkaline phosphatase in trabecular (bT-ALP) and cortical (bC-ALP) bone were determined as bone formation markers, and carboxy-terminal cross-linking telopeptides of type I collagen (CTX) in serum were measured as bone resorption marker. Serum concentration of calcium (Ca) and its renal handling, as well as Zn and Cd concentrations in the serum/blood, urine and femur were evaluated as well. The exposure to 5 and 50mg Cd/l (0.340+/-0.026 and 2.498+/-0.093mg Cd/kg body wt/24h, respectively), in a dose and duration dependent manner, affected bone turnover (inhibited bone formation and stimulated its resorption) and disturbed bone mineralization (decreased BMC, BMD and Zn concentration). Zn supply at the concentration of 30 and 60mg/l (1.904+/-0.123 and 3.699+/-0.213mg/kg body wt/24h, respectively) during Cd exposure influenced the Cd-induced disorders in bone metabolism. Zn administration to the Cd-exposed rats enhanced the bone ALP activity and prevented Cd-induced bone resorption, but had no statistically significant effect on BMC and BMD; however, mean values of the densitometric parameters in the rats receiving both Cd and Zn were higher than in those treated with Cd alone. Moreover, Zn supplementation at both levels of Cd exposure was found to prevent Cd accumulation in the femur and the Cd-induced decrease in bone Zn concentration. The results of the present study allow the conclusion that Zn supplementation during Cd exposure may partly protect from disorders in bone metabolism. The influence of Zn may be accompanied by its ability to prevent Cd-induced Zn deficiency and to decrease Cd accumulation in bone tissue. The findings seem to indicate that enhanced dietary intake of Zn in subjects chronically exposed to moderate and relatively high Cd levels may have a protective influence on the skeleton. SN - 0300-483X UR - https://www.unboundmedicine.com/medline/citation/17560002/Effect_of_zinc_supplementation_on_bone_metabolism_in_male_rats_chronically_exposed_to_cadmium_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0300-483X(07)00259-4 DB - PRIME DP - Unbound Medicine ER -