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Pharmacokinetics and bioavailability of gentiopicroside from decoctions of Gentianae and Longdan Xiegan Tang after oral administration in rats--comparison with gentiopicroside alone.
J Pharm Biomed Anal. 2007 Sep 03; 44(5):1113-7.JP

Abstract

The pharmacokinetics and bioavailability of gentiopicroside (GPS), an active component of the Gentian plant species, from orally administered decoctions of Gentianae (DG), or in combination with other plants in the prescription of Longdan Xiegan Tang (LXT), was compared in rats with oral administration of GPS alone, using doses adjusted to deliver equivalent amounts of GPS (150 mg/kg). Changes in plasma levels of GPS following oral administration of GPS or DG could be fitted to a one compartment open model with elimination half times (T(1/2)Ke) of 3.35+/-0.76 h and 6.21+/-3.07 h, respectively. Kinetics of plasma GPS following oral administration of LXT could be fitted to a two compartments open model with an elimination half time (T((1/2)beta)) of 3.83+/-1.54 h. The bioavailability of GPS from DG was markedly better, and that from LXT markedly worse, compared with GPS alone, as judged by the area under concentration-time curve (AUC) values of 70.0+/-13.9 microgh/ml (DG), 32.7+/-12.9 microgh/ml (GPS) and 19.1+/-5.9 microgh/ml (LXT). The study demonstrates the marked variability in pharmacokinetics and bioavailability of an active component from different herbal preparations.

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Authors+Show Affiliations

Wang CH
Key Laboratory of Standardization of Chinese Medicines, Ministry of Education, 1200 Cailun Road, Shanghai, China.
Cheng XM
No affiliation info available
Bligh SW
No affiliation info available
White KN
No affiliation info available
Branford-White CJ
No affiliation info available
Wang ZT
No affiliation info available

MeSH

Administration, OralAnimalsArea Under CurveBiological AvailabilityCalibrationChromatography, High Pressure LiquidFemaleGentianaGlucosidesHalf-LifeIridoid GlucosidesIridoidsMaleMolecular StructurePlant RootsPyransRatsRats, WistarReference StandardsReproducibility of Results

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17560062

Citation

Wang, Chang-hong, et al. "Pharmacokinetics and Bioavailability of Gentiopicroside From Decoctions of Gentianae and Longdan Xiegan Tang After Oral Administration in Rats--comparison With Gentiopicroside Alone." Journal of Pharmaceutical and Biomedical Analysis, vol. 44, no. 5, 2007, pp. 1113-7.
Wang CH, Cheng XM, Bligh SW, et al. Pharmacokinetics and bioavailability of gentiopicroside from decoctions of Gentianae and Longdan Xiegan Tang after oral administration in rats--comparison with gentiopicroside alone. J Pharm Biomed Anal. 2007;44(5):1113-7.
Wang, C. H., Cheng, X. M., Bligh, S. W., White, K. N., Branford-White, C. J., & Wang, Z. T. (2007). Pharmacokinetics and bioavailability of gentiopicroside from decoctions of Gentianae and Longdan Xiegan Tang after oral administration in rats--comparison with gentiopicroside alone. Journal of Pharmaceutical and Biomedical Analysis, 44(5), 1113-7.
Wang CH, et al. Pharmacokinetics and Bioavailability of Gentiopicroside From Decoctions of Gentianae and Longdan Xiegan Tang After Oral Administration in Rats--comparison With Gentiopicroside Alone. J Pharm Biomed Anal. 2007 Sep 3;44(5):1113-7. PubMed PMID: 17560062.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmacokinetics and bioavailability of gentiopicroside from decoctions of Gentianae and Longdan Xiegan Tang after oral administration in rats--comparison with gentiopicroside alone. AU - Wang,Chang-hong, AU - Cheng,Xue-mei, AU - Bligh,S W Annie, AU - White,Kenneth N, AU - Branford-White,Christopher J, AU - Wang,Zheng-tao, Y1 - 2007/05/05/ PY - 2007/02/03/received PY - 2007/03/26/revised PY - 2007/04/25/accepted PY - 2007/6/15/pubmed PY - 2007/12/6/medline PY - 2007/6/15/entrez SP - 1113 EP - 7 JF - Journal of pharmaceutical and biomedical analysis JO - J Pharm Biomed Anal VL - 44 IS - 5 N2 - The pharmacokinetics and bioavailability of gentiopicroside (GPS), an active component of the Gentian plant species, from orally administered decoctions of Gentianae (DG), or in combination with other plants in the prescription of Longdan Xiegan Tang (LXT), was compared in rats with oral administration of GPS alone, using doses adjusted to deliver equivalent amounts of GPS (150 mg/kg). Changes in plasma levels of GPS following oral administration of GPS or DG could be fitted to a one compartment open model with elimination half times (T(1/2)Ke) of 3.35+/-0.76 h and 6.21+/-3.07 h, respectively. Kinetics of plasma GPS following oral administration of LXT could be fitted to a two compartments open model with an elimination half time (T((1/2)beta)) of 3.83+/-1.54 h. The bioavailability of GPS from DG was markedly better, and that from LXT markedly worse, compared with GPS alone, as judged by the area under concentration-time curve (AUC) values of 70.0+/-13.9 microgh/ml (DG), 32.7+/-12.9 microgh/ml (GPS) and 19.1+/-5.9 microgh/ml (LXT). The study demonstrates the marked variability in pharmacokinetics and bioavailability of an active component from different herbal preparations. SN - 0731-7085 UR - https://www.unboundmedicine.com/medline/citation/17560062/Pharmacokinetics_and_bioavailability_of_gentiopicroside_from_decoctions_of_Gentianae_and_Longdan_Xiegan_Tang_after_oral_administration_in_rats__comparison_with_gentiopicroside_alone_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0731-7085(07)00255-5 DB - PRIME DP - Unbound Medicine ER -