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Clinical impact of influenza immunization in patients with liver cirrhosis.
J Clin Virol 2007; 39(3):159-63JC

Abstract

BACKGROUND

Influenza vaccine is considered to reduce influenza-related morbidity and mortality in patients with underlying chronic medical conditions. Yet in liver cirrhosis, influenza vaccines have received little attention in determining the potential benefits.

OBJECTIVES

We intended to evaluate the clinical benefits of influenza vaccination and clinical outcomes of influenza in patients with liver cirrhosis.

METHODS

We performed a controlled, prospective clinical trial of 311 cirrhotic patients, who were enrolled in October 2004. Among them, 198 patients were vaccinated with a trivalent influenza vaccine and the rest were not vaccinated. Both groups were followed with respect to the occurrence of influenza-like illness (ILI) until May 2005.

RESULTS

Overall incidences of ILI (p=0.064) and culture positivity of influenza (p=0.009) were remarkably higher in unvaccinated group compared to the vaccinated group. Most of the cirrhotic patients with influenza had fever (91.6%) and complained of myalgia (83.3%) without respiratory symptoms, which were not typical clinical presentations of influenza. Influenza vaccination also decreased influenza-related complication rates in patients with liver cirrhosis.

CONCLUSION

Influenza vaccination should be recommended to all cirrhotic patients. High suspicion is required for early diagnosis and antiviral treatment, allowing for the frequent hepatic decompensation among cirrhotic patients.

Authors+Show Affiliations

Division of Infectious Diseases, Department of Internal Medicine, Korea University, Seoul, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

17560166

Citation

Song, Joon Young, et al. "Clinical Impact of Influenza Immunization in Patients With Liver Cirrhosis." Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, vol. 39, no. 3, 2007, pp. 159-63.
Song JY, Cheong HJ, Ha SH, et al. Clinical impact of influenza immunization in patients with liver cirrhosis. J Clin Virol. 2007;39(3):159-63.
Song, J. Y., Cheong, H. J., Ha, S. H., Hwang, I. S., Kee, S. Y., Jeong, H. W., ... Kim, W. J. (2007). Clinical impact of influenza immunization in patients with liver cirrhosis. Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, 39(3), pp. 159-63.
Song JY, et al. Clinical Impact of Influenza Immunization in Patients With Liver Cirrhosis. J Clin Virol. 2007;39(3):159-63. PubMed PMID: 17560166.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical impact of influenza immunization in patients with liver cirrhosis. AU - Song,Joon Young, AU - Cheong,Hee Jin, AU - Ha,Seok Hoon, AU - Hwang,In Sook, AU - Kee,Sae Yoon, AU - Jeong,Hye Won, AU - Lee,Chang Gyu, AU - Kim,Woo Joo, Y1 - 2007/06/07/ PY - 2006/10/18/received PY - 2007/04/07/revised PY - 2007/04/24/accepted PY - 2007/6/15/pubmed PY - 2007/8/22/medline PY - 2007/6/15/entrez SP - 159 EP - 63 JF - Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology JO - J. Clin. Virol. VL - 39 IS - 3 N2 - BACKGROUND: Influenza vaccine is considered to reduce influenza-related morbidity and mortality in patients with underlying chronic medical conditions. Yet in liver cirrhosis, influenza vaccines have received little attention in determining the potential benefits. OBJECTIVES: We intended to evaluate the clinical benefits of influenza vaccination and clinical outcomes of influenza in patients with liver cirrhosis. METHODS: We performed a controlled, prospective clinical trial of 311 cirrhotic patients, who were enrolled in October 2004. Among them, 198 patients were vaccinated with a trivalent influenza vaccine and the rest were not vaccinated. Both groups were followed with respect to the occurrence of influenza-like illness (ILI) until May 2005. RESULTS: Overall incidences of ILI (p=0.064) and culture positivity of influenza (p=0.009) were remarkably higher in unvaccinated group compared to the vaccinated group. Most of the cirrhotic patients with influenza had fever (91.6%) and complained of myalgia (83.3%) without respiratory symptoms, which were not typical clinical presentations of influenza. Influenza vaccination also decreased influenza-related complication rates in patients with liver cirrhosis. CONCLUSION: Influenza vaccination should be recommended to all cirrhotic patients. High suspicion is required for early diagnosis and antiviral treatment, allowing for the frequent hepatic decompensation among cirrhotic patients. SN - 1386-6532 UR - https://www.unboundmedicine.com/medline/citation/17560166/Clinical_impact_of_influenza_immunization_in_patients_with_liver_cirrhosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1386-6532(07)00155-2 DB - PRIME DP - Unbound Medicine ER -