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Successful treatment of extramedullary gastric plasmacytoma with the combination of bortezomib and dexamethasone: first reported case.
Leuk Res. 2008 Feb; 32(2):339-41.LR

Abstract

We report a case of a 68-year-old man presented with upper-gastrointestinal bleeding. Endoscopy showed a large ulcerated gastric mass. Histological examination of the gastric biopsies revealed a k monoclonal extramedullary plasmacytoma (EMP). Further staging was negative for multiple myeloma. The patient was managed with bortezomib at a dose of 1.3mg/m2 on days 1, 4, 8 and 11 of a 21-day cycle in combination with dexamethasone 20mg p.o. on days 1, 2, 4, 5, 8, 9 and 11, 12 of each cycle. After 4 cycles of treatment, no endoscopic or histological findings of EMP were found. Thirteen months after diagnosis the patient is in complete remission with no evidence of local relapse or evolution to multiple myeloma. This is the first reported case of EMP successfully managed with the combination of bortezomib and dexamethasone.

Authors+Show Affiliations

Theagenion Cancer Center, Hematology, Eyrygeni 6B, 54249 Thessaloniki, Greece. ikatodritou@otenet.grNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

17560647

Citation

Katodritou, Eirini, et al. "Successful Treatment of Extramedullary Gastric Plasmacytoma With the Combination of Bortezomib and Dexamethasone: First Reported Case." Leukemia Research, vol. 32, no. 2, 2008, pp. 339-41.
Katodritou E, Kartsios C, Gastari V, et al. Successful treatment of extramedullary gastric plasmacytoma with the combination of bortezomib and dexamethasone: first reported case. Leuk Res. 2008;32(2):339-41.
Katodritou, E., Kartsios, C., Gastari, V., Verrou, E., Mihou, D., Banti, A., Lazaraki, G., Lazaridou, A., Kaloutsi, V., & Zervas, K. (2008). Successful treatment of extramedullary gastric plasmacytoma with the combination of bortezomib and dexamethasone: first reported case. Leukemia Research, 32(2), 339-41.
Katodritou E, et al. Successful Treatment of Extramedullary Gastric Plasmacytoma With the Combination of Bortezomib and Dexamethasone: First Reported Case. Leuk Res. 2008;32(2):339-41. PubMed PMID: 17560647.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Successful treatment of extramedullary gastric plasmacytoma with the combination of bortezomib and dexamethasone: first reported case. AU - Katodritou,Eirini, AU - Kartsios,Charalambos, AU - Gastari,Vassiliki, AU - Verrou,Evgenia, AU - Mihou,Dimitra, AU - Banti,Anastasia, AU - Lazaraki,Georgia, AU - Lazaridou,Anna, AU - Kaloutsi,Vassiliki, AU - Zervas,Konstantinos, Y1 - 2007/06/08/ PY - 2007/03/09/received PY - 2007/04/25/revised PY - 2007/04/29/accepted PY - 2007/6/15/pubmed PY - 2008/5/21/medline PY - 2007/6/15/entrez SP - 339 EP - 41 JF - Leukemia research JO - Leuk Res VL - 32 IS - 2 N2 - We report a case of a 68-year-old man presented with upper-gastrointestinal bleeding. Endoscopy showed a large ulcerated gastric mass. Histological examination of the gastric biopsies revealed a k monoclonal extramedullary plasmacytoma (EMP). Further staging was negative for multiple myeloma. The patient was managed with bortezomib at a dose of 1.3mg/m2 on days 1, 4, 8 and 11 of a 21-day cycle in combination with dexamethasone 20mg p.o. on days 1, 2, 4, 5, 8, 9 and 11, 12 of each cycle. After 4 cycles of treatment, no endoscopic or histological findings of EMP were found. Thirteen months after diagnosis the patient is in complete remission with no evidence of local relapse or evolution to multiple myeloma. This is the first reported case of EMP successfully managed with the combination of bortezomib and dexamethasone. SN - 0145-2126 UR - https://www.unboundmedicine.com/medline/citation/17560647/Successful_treatment_of_extramedullary_gastric_plasmacytoma_with_the_combination_of_bortezomib_and_dexamethasone:_first_reported_case_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0145-2126(07)00165-8 DB - PRIME DP - Unbound Medicine ER -